Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics)
Epigenetics Podcast16 Maalis 2022

Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics)

In this episode of the Epigenetics Podcast, we caught up with Ben Hindson, Chief Scientific Officer at 10X Genomics, to talk about single-cell technologies using microfluidics.

Epigenetics has moved well past a simple understanding of a single epigenetic layer of control at genomic regions of interest, thanks to advances in many techniques and the application of “multiomics”. We can now analyze genome-wide histone modification patterns, transcription factor binding profiles, chromatin accessibility profiles, three-dimensional chromosomal conformation, and DNA methylation dynamics combined with transcriptomic analyses and associated analytical platforms.

Bulk Assays, like ATAC-Seq or ChIP, despite all their advantages, do not provide information about the chromatin states of individual subpopulations of cells within a sample. To identify chromatin features in heterogeneous populations, such as blood, pancreas, and brain, those analysis need to be performed at a single-cell level. 10X Genomics has been at the forefront of the movement into the single cell space and in this Episode we discuss this work with Ben Hindson, CSO of 10X genomics.

References

Related Episodes

Contact

Jaksot(171)

The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano)

The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano)

In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. We exp...

21 Marras 202440min

Grant Writing in Academia and Industry – Tips for Success (Mary Anne Jelinek)

Grant Writing in Academia and Industry – Tips for Success (Mary Anne Jelinek)

In this episode of the Epigenetics Podcast, we talked with Mary Anne Jelinek Associate Director of R&D at Active Motif about writing and reviewing grants in academia and industry. Learn from Dr. Jelin...

14 Marras 202439min

DNase Hypersensitive Sites and Chromatin Remodeling Enzymes (Carl Wu)

DNase Hypersensitive Sites and Chromatin Remodeling Enzymes (Carl Wu)

In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in ...

31 Loka 202455min

Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou)

Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou)

In this episode of the Epigenetics Podcast, we talked with Mitinori Saitou from Kyoto University about his work on germ cell development, focusing on proteins like BLIMP1 and PRDM14, reprogramming iPS...

17 Loka 202439min

Malaria Chromatin Structure and its Transcriptional Regulation (Karine Le Roch)

Malaria Chromatin Structure and its Transcriptional Regulation (Karine Le Roch)

In this episode of the Epigenetics Podcast, we talked with Karine Le Roch from the University of California at Riverside about her work on malaria chromatin structure and its transcriptional regulatio...

3 Loka 202441min

Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel)

Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel)

In this episode of the Epigenetics Podcast, we talked with Bas van Steensel from the Netherlands Cancer Institute about his work on characterizing chromatin at the Nuclear Lamina. The Interview starts...

19 Syys 202440min

Nucleosome Positioning in Cancer Diagnostics (Vladimir Teif)

Nucleosome Positioning in Cancer Diagnostics (Vladimir Teif)

In this episode of the Epigenetics Podcast, we caught up with Vladimir Teif from the University of Essex to talk about his work on nucleosome positioning in development and disease. Vladimir's researc...

5 Syys 202440min

The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine)

The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine)

In this episode of the Epigenetics Podcast, we talked with Johnathan Whetstine from Fox Chase Cancer Center about his work on how histone demethylases affect gene expression and cancer cell stability....

29 Elo 202439min

Suosittua kategoriassa Tiede

rss-mita-tulisi-tietaa
tiedekulma-podcast
rss-poliisin-mieli
utelias-mieli
rss-duodecim-lehti
mielipaivakirja
rss-metsantuntijat-podcast
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
university-of-eastern-finland
docemilia
vinkista-vihia
rss-vaasan-yliopiston-podcastit
rss-duokkari-ekstra
rss-astetta-parempi-elama-podcast
rss-tiedetta-vai-tarinaa
rss-pandapodi
rss-lapsuuden-rakentajat-podcast
rss-miljonaarien-tasavalta