How To Get 6 Gigabytes Of Data From Your Gut: The Fascinating Future Of Stool, Blood, Saliva & Urine Testing (From The Comfort Of Your Own Home).
Boundless Life26 Tammi 2019

How To Get 6 Gigabytes Of Data From Your Gut: The Fascinating Future Of Stool, Blood, Saliva & Urine Testing (From The Comfort Of Your Own Home).

Imagine an all-encompassing platform that allows you to keep track of all your blood, stool, saliva, and urine testing results, along with self-quantified data from wearables, and even pulls in all health testing you've done in the past as part of a single dashboard. And imagine that platform could then use highly advanced artificial intelligence to tell you exactly how to eat, how to supplement, how to exercise and much more.

All from the comfort of your home, without needing to drive to an expensive lab for multiple blood draws or fill out confusing paperwork. That's exactly what the brand new company Onegevity Health has the money, technology and data to do, and so I decided it was high time I sat down with their two chief scientists to learn exactly how this process works. I've already sent in my own stool using their Gut/bio shotgun stool sequencing test that we discuss in this episode.

My guests are Dr. Joel Dudley and Dr. Chris Mason. These guys are highly qualified and wicked smart.

Dr. Dudley is currently Associate Professor of Genetics and Genomic Sciences, Endowed Chair of Biomedical Data Science, and founding Director of the Institute for Next Generation Healthcare at the Icahn School of Medicine at Mount Sinai. Prior to Mount Sinai, he held positions as Co-founder and Director of Informatics at NuMedii, Inc. and Consulting Professor of Systems Medicine in the Department of Pediatrics at Stanford University School of Medicine.

His work, published in >120 peer-review publications, is focused at the nexus digital health, artificial intelligence (AI), scientific wellness, and healthcare delivery. His work has been featured in the Wall Street Journal, Scientific American, MIT Technology Review, CNBC, and other popular media outlets. He was named in 2014 as one of the 100 most creative people in business by Fast Company magazine. He is co-author of the book Exploring Personal Genomics from Oxford University Press. Dr. Dudley received a BS in Microbiology from Arizona State University and an MS and PhD in Biomedical Informatics from Stanford University School of Medicine.

Dr. Christopher Mason is currently an Associate Professor at Weill Cornell Medicine, with appointments at the Tri-Institutional Program in Computational Biology and Medicine between Cornell, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medicine, the Sandra and Edward Meyer Cancer Center, and the Feil Family Brain and Mind Research Institute. He is also Director of the WorldQuant Initiative for Quantitative Prediction, which bridges prediction methods in finance with genomics. His work spanning >140 peer-reviewed publications has been featured on the cover of Science, Nature, and Cell journals as well as the New York Times, Wall Street Journal, CNN, Forbes, and other major media outlets.

Dr. Mason was featured as a speaker at TEDMED and he was recognized in 2014 as one of the “Brilliant Ten” by Popular Science magazine. He completed his dual B.S. in Genetics and Biochemistry (2001) from University of Wisconsin-Madison, his Ph.D. in Genetics (2006) from Yale University, and then completed post-doctoral training in clinical genetics (2009) at Yale Medical School while jointly a post-doctoral Fellow of Genomics, Ethics, and Law at Yale Law School (2009).

During the show, you'll discover: -What Onegevity is, and what it does...9:45
  • "Health intelligence" company
  • History of the company
    • Frustration with how long it takes research to reach the consumer
    • 17 years to reach just the clinic; many years after that to reach the consumer
  • How is it different from other biome testing companies
    • Shotgun sequencing vs. 16S
    • Translate the results along with actionable steps to take
    • Recreational health information vs. health management companies
    • Vertically integrated with Thorne, who develops the actual solutions
    • Starting over in some ways in the realm of microbiome testing
-What is metatranscriptome analysis?...18:00
  • "Meta" = Across all species
  • DNA + RNA analysis
  • Challenges with RNA analysis - some clinicians consider it useless
  • Only top few % of species generate RNA in the sample
  • Comparable in price to shotgun sequencing
-The actual testing process at Onegevity...20:45
  • Very small stool sample required, as compared to other tests
  • 6 gigabytes of data after sequencing DNA
  • Each fragment compared to all known species on earth
  • Interactive report on the web; suggestions on what food and supplements to order
  • Network modeling:
    • How are changes in the microbiome propagating to the blood
    • More comprehensive than guessing based on correlations
  • What is measured in the blood?
    • TBD based on the individual's health
-How Joel and Chris overcome challenges and skepticism in their testing processes...28:20
  • How can you measure the whole gut with a stool sample? (Spatial microbiome testing)
  • Not necessary, even harmful, to sample from other areas of the gut
-The role of artificial intelligence (AI) in the testing process at Onegevity...36:40
  • Predicts diseases/conditions based on the shotgun sequencing
  • Recommend foods and supplements to consume
  • Each company has its own variables, testing protocols, etc.; results in differing test results
  • Database continues to grow with each test; data becomes more reliable
  • Data is not for sale to outside parties; will partner under the right conditions
-How do you go from stool, to shotgun sequencing, to "don't eat green beans?"...40:35
  • Internal trial; shocking results
  • Can determine the efficacy of the test at certain benchmarks; 15 day, 30 day, etc.
  • Very positive feedback from those who were tested
  • Does Thorne produce a special probiotic that seeds the gut?
-How comprehensive are the dietary recommendations after a Onegevity test?...48:52
  • Not simply a particular diet, i.e. Mediterranean, Ketogenic, etc.
  • Can make specific food, meal recommendations
  • Possibly partner with food delivery services to provide customized options
  • Very close to being perfectly genetically tailored in both microbiome and saliva tests
-How customer data is protected if Joel and Chris choose to partner with a pharmaceutical company...55:20
  • Customers are opted out by default; can choose to opt in.
  • Potential to benefit monetarily by opting in
-What the Onegevity platform looks like from a user standpoint...1:01:55 -And much more! Resources from this episode:

-Click here to visit OnegevityHealth.com for the testing we discuss in this episode. Use discount code BEN20 to receive $20 off your own test.

-Book: Exploring Personal Genomics by Joel Dudley

Episode Sponsors:

-Kion My own company where I develop coffees, energy bars and supplements. I'm also proud to endorse the Thorne line of supplements, including the multi-vitamin, which I take every day.

-Organifi Gold Wake up each day feeling rested. Relax your body after a long day. Help stiff joints feel young again. Use discount code “greenfield” and get 20% off your entire order!

-Thrive Market Your Favorite Organic Foods and Products. Up to 50% Off. Delivered to Your Door. Use my link and get an extra 25% off your first order.

-PuraThrive Keto Balance Gently push your body into Ketosis in a healthy manner so your body turns into a fat-burning machine (and stays in fat-burning mode). Get 15% off your order when you use my link.

Do you have questions, thoughts or feedback for Joel, Chris or me? Leave your comments at http://bengreenfieldfitness.com/onegevity and one of us will reply!

See omnystudio.com/listener for privacy information.

Jaksot(1746)

Anti-Aging Secrets Of The World's Longest-Lived Woman, The Top Longevity "Drugs", Fat Loss & Muscle Gain Tips & Much More! Q&A 494

Anti-Aging Secrets Of The World's Longest-Lived Woman, The Top Longevity "Drugs", Fat Loss & Muscle Gain Tips & Much More! Q&A 494

Full Show Notes: https://bengreenfieldlife.com/494 In this episode, I dig into the fascinating story of the world’s oldest woman—a vibrant supercentenarian from Spain who made it to 117 years old. I break down what researchers discovered about her genes, lifestyle, and daily habits (you might be surprised by some of the things she ate and didn’t do!). I also get nerdy about the newest longevity drugs and supplements—like curcumin, spermidine, taurine, and a few others you might not expect—and explain which ones actually work, according to the science in mammals. Plus, I share some updates from my own life, like the weirdly exciting health setting I just found on my new iPhone, and spill the beans on why I microdose alcohol (and sometimes other things) instead of going on a bender. If you’re curious about muscle gain (do you really need to be in a calorie surplus?), soft-shell vs hardshell hyperbaric chambers, or how certain supplements might actually help you live longer, you’re in the right place. There’s a lot of info coming your way, and I’ve tried to translate all the geeky science into practical tips for you to use. Episode Sponsors: Health Lighting: If you want to see and feel the difference better light can make in your life, give Chromalux® full spectrum light bulbs a try. Go to healthlighting.com and use code Ben10 at checkout to save 10% off your order. Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at Sunlighten.com/BEN with code BEN. IM8: Ditch the cabinet full of supplements—IM8 packs 92 powerhouse ingredients into one delicious scoop for all-day energy, gut health, and cellular support. Go to IM8Health.com and use code BEN for an exclusive gift—fuel your body the right way! Gameday Men’s Health: Gameday Men's Health offers science-backed, physician-led men's health optimization with personalized protocols for testosterone, peptide therapy, ED treatment, and more—helping you perform at your best whether you're training hard or keeping up with life. Visit gamedaymenshealth.com/bengreenfield for a free testosterone test and consultation at a clinic near you. LMNT: Everyone needs electrolytes, especially those on low-carb diets, who practice intermittent or extended fasting, are physically active, or sweat a lot. Go to DrinkLMNT.com/BenGreenfield to get a free sample pack with your purchase!See omnystudio.com/listener for privacy information.

30 Loka 202538min

Women — You Need To Hear THIS! Testosterone & Steroids For a Better Body, How To Have *Mind-Blowing,* Juicy Sex (Throughout Menopause and Beyond!) & Much More With Dr. Amie Hornaman (Best of LIFE Network's Experts!)

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Full Show Notes: https://bengreenfieldlife.com/lnamie/ Low libido... brain fog... and decreased muscle mass — many women face these issues without realizing they could be linked to hormone imbalances, particularly low testosterone levels. As you navigate through perimenopause or menopause, the overlapping symptoms can be confusing and frustrating, making it difficult to pinpoint the root cause and find effective solutions. In this episode, Dr. Amie Hornaman and I dive deep into the often-overlooked aspects of hormone management, with a special focus on testosterone's pivotal role in women's health. From understanding the complex interactions between testosterone and thyroid levels to exploring the best methods for hormone testing, you'll receive a comprehensive guide to optimizing your hormone balance. You'll also gain insights into various testosterone replacement methods, strategies to manage side effects, and tips on integrating peptide therapy for enhanced recovery and growth hormone levels. Whether you're seeking to boost your libido, enhance cognitive function, or maintain muscle mass, this episode offers practical advice to help you achieve your health goals. Dr. Amie is a certified functional medicine practitioner, a women's hormone specialist, and has a doctorate in clinical nutrition. Dr. Amie helps patients navigate thyroid and hormone supplements and provides thyroid support resources. Dr. Amie's patients are located around the world, including the US, UK, and Australia, and she uses telehealth to help thousands of patients each year. Episode Sponsors: Ketone-IQ: Ketone-IQ delivers science-backed performance fuel that increases power output by 19%, reduces fatigue by 10%, and naturally boosts EPO production for better oxygen delivery—trusted by elite athletes like Jon Jones and Olympic champions. Save 30% on your subscription plus get a free gift with your second shipment at Ketone.com/BENG. Muse: Muse S Athena combines clinical-grade EEG and fNIRS technology to train your brain in real time while tracking sleep with 86% expert-level accuracy. Get 15% off at choosemuse.com/BENGREENFIELD or use code BENGREENFIELD at checkout. Pique: Pique Teas is where plants and science intersect to produce teas and supplements of unrivaled efficacy, purity, and convenience. Go to Piquelife.com/Ben to get 20% off for life, plus a free starter kit with a rechargeable frother and glass beaker to elevate your ritual. ZBiotics Pre-Alcohol Probiotic: The world's first genetically engineered probiotic that helps break down the toxic byproduct of alcohol, Zbiotics Pre-Alcohol allows you to enjoy your night out and feel great the next day. Order with the confidence of a 100% money-back guarantee and 15% off your first order at zbiotics.com/BEN15. Our Place: Upgrade to Our Place today and say goodbye to forever chemicals in your kitchen. Go to fromourplace.comand enter my code BEN at checkout to receive 10% off sitewide. Boundless Bar: If you’re ready to fuel workouts, sharpen your focus, and support whole-body vitality, grab your Boundless Bars now at boundlessbar.com —and save 10% when you sign up for a Boundless Bar subscription. Want to Hear More from Dr Amie and Other Leading Health Experts?Click Here to Join LIFE Network for FreeSee omnystudio.com/listener for privacy information.

25 Loka 202551min

The Healthiest Way To Light Your Home For Optimizing Sleep & Energy (& How To Sleep Better When You TRAVEL!) With Block Blue Light's Daniel Ebbett

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23 Loka 202555min

Is There *Actually* Any Research On QUANTUM Fields Affecting Your Health? (You'll Be Blown Away By What You Learn!) With Ian Mitchell & Philipp von Holtzendorff-Fehling

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18 Loka 202552min

An Insider Glimpse Into The Morning Routines, Biohacking Stacks & Relationship-Building Tactics Of A Successful Executive (& What It's Like To Be Coached By Ben!), With Brian McMaster

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16 Loka 202559min

The SUPERHUMAN Protocol That Declumps Cells, Hyperoxygenates The Body, Restores Cellular Wellness & *Much* More, With Gary Brecka (Best of LIFE Network's Experts!)

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11 Loka 20251h 14min

A Fascinating Fireside Chat with Actor Luke Cook: Cyclical Keto, Ketones, Cold Plunges, Nootropics, Peptides & Living VITAL to the End!

A Fascinating Fireside Chat with Actor Luke Cook: Cyclical Keto, Ketones, Cold Plunges, Nootropics, Peptides & Living VITAL to the End!

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9 Loka 202545min

Can a Cultured Mushroom Extract *REALLY* Shrink Tumors, Clear HPV & Supercharge Immunity?, with Meagan Lindquist

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In this episode with Meagan Lindquist, you’ll discover the world of AHCC, a cultured mushroom extract with a remarkable range of health benefits. We explore its origins, patented culturing process in Japan, and what makes AHCC uniquely bioavailable compared to other mushroom supplements. Meagan shares her health journey, her experiences supporting patients, and her passion for spreading awareness about AHCC’s research-backed potential—from cancer and HPV to Lyme disease and overall immune function. The conversation highlights AHCC’s role as an immunomodulator, antioxidant, and anti-inflammatory compound, reviewing studies that demonstrate its benefits for general immune support and as complementary therapy for serious conditions, such as cancer and chronic infections. Practical topics include supplement quality, dosing, and how to find credible sources. By the end, you’ll have insights and actionable information to evaluate AHCC as part of a thoughtful, science-driven approach to immune optimization and integrative health. Meagan (Mimi) Lindquist (@mimi_themedicin) is the co-founder of The Medicin, alongside her husband Chase. Together, they provide high-quality mushroom products to the world. With her background as a clinical dental hygienist, nutrition guide, and AHCC educator, she has been helping others prevent disease for over 12 years. Now, Mimi is dedicated to sharing the benefits of Immune Intel AHCC, a mushroom product unlike any other, to as many people as possible. She hosts monthly live calls with Dr. Nathan Riley for women trying to clear HPV naturally using AHCC. In her words, it is her "life's passion to spread the word about how powerful it is." Full show notes: bengreenfieldlife.com/ahccpodcast Episode Sponsors: Organifi Shilajit Gummies: Harness the ancient power of pure Himalayan shilajit anytime you want with these convenient and tasty gummies. Get them now for 20% off at organifi.com/Ben. BlockBlueLight: BlockBlueLight BioLights are the only lights extensively tested and recommended by building biologist Brian Hoyer as truly flicker-free, ultra-low EMF, and circadian-friendly, with three modes (day, evening, night) that support natural rhythms and optimize sleep quality. Get 10% off your first order at blockbluelight.com/Ben (discount autoapplied at checkout). Fatty15: Fatty15 is on a mission to optimize your C15:0 levels and help you live healthier, longer. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/BEN and using code BEN at checkout. LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to bengreenfieldlife.com/lvluphealth and use code BEN15 for a special discount on their game-changing range of products. BiOptimizers Magnesium Breakthrough: The 7 essential forms of magnesium included in this full spectrum serving help you relax, unwind, and turn off your active brain after a long and stressful day so you can rest peacefully and wake up feeling refreshed, vibrant, and alert. Go to bioptimizers.com/ben and use code ben15 for 15% off any order.See omnystudio.com/listener for privacy information.

4 Loka 202552min

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