Semaglutide, Tirzepatide, and Mental Health Benefits of TRT

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On today's episode we discuss the following:

• Semaglutide (Wegovy) and Tirzepatide (Mounjaro)
• TRT Mental Health Benefits
• Anxiety

TRT Community Post - I posted this short blog, about weight loss drugs in the TRT Community Facebook group. The first sentence was something like, "Losing weight can be an incredibly difficult endeavor…" A fellow responded and informed me that losing weight is not difficult and a conversation ensued.

Just because something has a step process you can follow, doesn't make it easy. I could rebuild a transmission with the proper instructions, but there's a reason specialty shops exist. Have you ever had a pack of clutch plates laying on a work bench???

Topic One: Semaglutide & Tirzepitide

Semaglutide -

• it's sold as Ozempic and Rybelsus for DM treatment and Wegovy for weight loss.
• Brain uses hormones to regulate functions, including digestion and metabolism
• Semaglutide mimics the action of GLP-1 class hormones
• GLP-1, or glucagon like peptide-1 help regulate digestion and metabolism
• The more GLP-1, the more full you are
• Side effects - Diarrhea, Nausea, Constipation, vomiting

Tirzepatide

(Mounjaro) currently approved for DM treatment

• Same GLP-1 effects as Semaglutide
• Also effect on GIP (glucose=dependent insulinotropic polypeptide)
• GIP enhances the action of GLP-1, which tells the brain to stop eating.
• The way I think about it is like this: Semaglutide, Ozempic, Rybelsus, Wegovy - it's like having a fellow in your brain telling you to stop eating. Tirzepatide or Mounjaro is like have 2 fellows in your brain TELLING you to stop eating.
• The most effective weight loss medication ever made available with an average weigh tloss of 22.5% over the course of a year.

Personal experience - started taking Semaglutide about 7 months ago. Lost about 10% BW in a few months and plateaued. Started Tirzepatide this month. Not much side effects. Feeling bloated/full most of the time

Tirzepatide highly effective for weight loss - PubMed (nih.gov)

Facebook Questions:

Did TRT improve your anxiety and confidence? Maybe is the fact that I'm autistic, but all my life Ive been prone to being anxious when interacting with others regardless of how many times I do it. I'm 38 and even if I'm "relaxed" there is still a "slight" anxiety underneath that's probably unseen by others yet I feel it. Maybe I'm just a nervous person but I have noticed my anxiety has gotten worse compared to 10 years ago. I feel more confident than when I was younger from life experience and maturity but still anxious. I'm also more prone to being fearful than some but I fight it and contain it. I wish I was like those guys seem to have no fear and have nerves of steel. That's life but who knows maybe i have a bigger weiner or higher IQ than them.

So many folks focus on the physical improvement aspects of TRT. The mental health benefits are what I'm most passionate about. Before TRT - I was anxious daily, no confidence, counting hours before I had to do things like go to work, afraid to speak up, engage people in social situations, seeking validation from other people and manipulating them into providing you with value. I was super impatient. Here's a quick video of my after experience

Before and After Testosterone Replacement Therapy

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