To RNase or Not to RNase: That Is the Question

To RNase or Not to RNase: That Is the Question

Join Dr. Anna Wolska and Dr. Jim Posada as they delve into the intricacies of RNAse therapy in the management of Systemic Lupus Erythematosus (SLE). In this podcast episode, Dr. Posada describes the groundbreaking study evaluating the efficacy of RSLV-132, a novel RNAse molecule fused to human IgG1 Fc, in reducing chronic inflammation associated with cutaneous lupus. Key findings from the clinical trial reveal that patients with moderate to severe cutaneous disease activity were administered RSLV-132 over a span of six months. Disease activity was evaluated using the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) score and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). These findings suggest that RNAse therapy may be effective in patients with higher disease activity.

Read the related paper in LSM - https://doi.org/10.1136/lupus-2023-001113

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(60)

Making Sense of Severe Lupus: How the SLE-DAS Tool Could Improve Care Outcomes

Making Sense of Severe Lupus: How the SLE-DAS Tool Could Improve Care Outcomes

In this episode of the Lupus Foundation of America podcast, Jaren Crump sits down with Dr. Luís Inês, rheumatologist and President of the European Lupus Society, about new research that could change h...

4 Elo 202517min

Inside Lupus: The Potential of Genetic Endotypes to Personalize Lupus Care

Inside Lupus: The Potential of Genetic Endotypes to Personalize Lupus Care

In this episode of the Lupus Science and Medicine Podcast, host Dr. Anna Wolska speaks with Dr. Amerie Grammer about how genetic breakthroughs are paving the way for personalized lupus care. Researche...

7 Heinä 202515min

Empowering Lupus Patients: A Treatment Measure Shaped by Their Voices

Empowering Lupus Patients: A Treatment Measure Shaped by Their Voices

In this podcast, Dr. Anna Wolska sits down with Dr. Eric Morand to discuss a groundbreaking effort to improve how lupus treatment success is measured in clinical trials. Dr. Morand explains why existi...

7 Touko 202518min

Steroid Use for the Treatment of Lupus Nephritis

Steroid Use for the Treatment of Lupus Nephritis

Lupus nephritis, affecting nearly half of lupus patients, can cause severe kidney damage. Traditionally, high-dose glucocorticoids (~1 mg per kg prednisone) have been used despite significant side eff...

7 Huhti 202512min

Validating Claims Algorithms for SLE: Geospatial Insights and Impacts on Health Disparities

Validating Claims Algorithms for SLE: Geospatial Insights and Impacts on Health Disparities

Join Dr. Anna Wolska from the Lupus Foundation of America as she talks with Dr. Jim Oates about his recently published study in Lupus Science & Medicine on validating claims-based algorithms in Medica...

3 Maalis 202513min

Rethinking Lupus Nephritis Treatment: Voclosporin vs. High-Dose Steroids

Rethinking Lupus Nephritis Treatment: Voclosporin vs. High-Dose Steroids

Early reduction in proteinuria is a key predictor of improved long-term kidney health in lupus nephritis (LN). In this episode, Dr. Anna Wolska from the Lupus Foundation of America speaks with Drs. Ma...

3 Helmi 202545min

Rituximab in Childhood Lupus: Insights and Safety

Rituximab in Childhood Lupus: Insights and Safety

Join Dr. Anna Wolska and Dr. Jordan Roberts, a pediatric rheumatologist, as they explore the use of Rituximab in treating childhood-onset systemic lupus erythematosus (SLE). They discuss key factors f...

6 Tammi 202515min

Managing Pregnancy in Lupus: Contraception Use and Beyond

Managing Pregnancy in Lupus: Contraception Use and Beyond

In this episode of the Lupus Science and Medicine podcast, Dr. Megan Clowse, a rheumatologist at Duke University, discusses her research on contraceptive practices in women with lupus. Drawing from th...

7 Loka 202425min

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