Artesunate treatment in severely injured patients with traumatic haemorrhage
ESICM Talk20 Syys 2023

Artesunate treatment in severely injured patients with traumatic haemorrhage

Multiple organ dysfunction syndrome (MODS) is common after major trauma, affecting up to two-thirds of patients with critical injuries. Post-trauma MODS is associated with a mortality of over 20% and poor long-term outcomes in those who survive. Current management is supportive, and there are no specific pharmacological agents that prevent organ dysfunction.

The TOP-ART randomised clinical trial, a two-stage study, has tested firstly the safety and efficacy of the early artesunate administration on a cohort of severely injured and bleeding trauma patients and, secondly, the outcomes of artesunate administration on trauma patients at risk of developing MODS.

Listen to Joanna Shepherd's interview in the following podcast to learn more about the study's results.

Original article: Safety and efficacy of artesunate treatment in severely injured patients with traumatic haemorrhage. The TOP-ART randomised clinical trial

Speakers:

Joanna SHEPHERD. Centre for Trauma Sciences, The Blizard Institute, Queen Mary University of London (UK).

Rahul COSTA-PINTO. Austin Hospital, Melbourne (AU). ESICM NEXT Committee Member.

Jaksot(90)

Life after sepsis in adult and paediatric patients

Life after sepsis in adult and paediatric patients

Sepsis is a life-threatening acute organ dysfunction secondary to infection and affects more than 19 million people annually. In 2017, it was estimated that almost 49 million people were infected by s...

13 Syys 202325min

Severe meningoencephalitis in the ICU: results from the EURECA study

Severe meningoencephalitis in the ICU: results from the EURECA study

Central nervous system (CNS) infections significantly burden ICU physicians' daily clinical work. Diagnosis can be challenging, and timely management is of the utmost importance. Meningoencephalitis i...

6 Syys 202318min

Diabetes mellitus in old critically ill COVID-19 patients

Diabetes mellitus in old critically ill COVID-19 patients

Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old, critically ill patients are particularly at risk. A recent multicentre inte...

30 Elo 202310min

Results from the TAME trial

Results from the TAME trial

International guidelines recommend targeting normocapnia in adults with coma resuscitated after out-of-hospital cardiac arrest. However, normocapnia may be insufficient to restore and maintain adequat...

27 Kesä 202325min

Guidelines for the management of severe community-acquired pneumonia

Guidelines for the management of severe community-acquired pneumonia

Severe community‐acquired pneumonia (sCAP) is a clinical entity to describe ICU-admitted patients with community‐acquired pneumonia (CAP) as they might require organ support, and it is associated with...

24 Touko 202320min

Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis

Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis

Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis. Reduced renal clearance has the surprising and count...

17 Touko 202343min

How to manage coagulopathies in critically ill patients

How to manage coagulopathies in critically ill patients

Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Therefore, a review has ...

10 Touko 202320min

End of Life Care concepts in intensive care

End of Life Care concepts in intensive care

End-of-life care is an approach to a terminally ill patient that shifts the focus of care to symptom control, comfort, dignity, quality of life, and quality of dying rather than treatments aimed at cu...

3 Touko 202330min

Suosittua kategoriassa Liike-elämä ja talous

sijotuskasti
mimmit-sijoittaa
psykopodiaa-podcast
rss-rahapodi
rss-draivi
rss-rahamania
ostan-asuntoja-podcast
rss-sami-miettinen-neuvottelija
pomojen-suusta
inderespodi
rss-seuraava-potilas
herrasmieshakkerit
taloudellinen-mielenrauha
oppimisen-psykologia
rss-h-asselmoilanen
rss-paasipodi
rss-inderes
asuntoasiaa-paivakirjat
rss-lahtijat
rss-bisnesta-bebeja