Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes
ESICM Talk20 Maalis 2024

Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Despite progress in the understanding of sepsis pathophysiology, no specific treatment has proven successful. The precision therapy, a greater understanding of the heterogeneity of sepsis is needed.

Recent approaches to measuring sepsis heterogeneity used unsupervised computational methods on clinical, biomarker, or gene expression data from observational studies or clinical trial datasets. At present, more than 100 sepsis subtypes are proposed, without awareness of overlap (or clinical implications). It is unknown whether each new subtype strategy is an added value for the patient.

To address this knowledge gap, a study was conducted aiming to determine the concordance between different sub-type labels, outcomes, and biologic pathways of critically ill sepsis patients classified by previously proposed sepsis subtyping methods. Listen to the podcast and learn more about the methodology and findings of this study.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(97)

Is the curtain falling on pre-hospital whole blood?

Is the curtain falling on pre-hospital whole blood?

Whole blood has made a remarkable comeback in trauma care—but is it here to stay? In this thought-provoking podcast, leading experts unpack the latest evidence comparing whole blood with component the...

6 Heinä 25min

Switching from controlled to assisted ventilation: evidence, risks, and opportunities in AHRF?

Switching from controlled to assisted ventilation: evidence, risks, and opportunities in AHRF?

What are the benefits of moving from controlled to assisted mechanical ventilation in patients with Acute Hypoxemic Respiratory Failure (AHRF)? In this podcast, experts discuss the physiological ratio...

8 Kesä 38min

Biomarkers in Severe Infections and Sepsis - Moving from Trials to the Bedside

Biomarkers in Severe Infections and Sepsis - Moving from Trials to the Bedside

Sepsis care is evolving fast. Are you keeping up? Don’t miss this podcast episode, where we explore the latest clinical trials reshaping antibiotic therapy for severe infections, from optimised treatm...

27 Touko 25min

Advanced Practice in Nursing and Allied Health Professionals

Advanced Practice in Nursing and Allied Health Professionals

What does advanced practice really look like in the ICU? In this podcast episode, we are joined by two advanced intensive care practitioners who share their roles, career journeys, and impact within t...

13 Touko 43min

Unmet Needs in PICS: Are We Measuring What Matters?

Unmet Needs in PICS: Are We Measuring What Matters?

What truly matters in recovery after critical illness? In this episode, we explore the unmet needs in Post-Intensive Care Syndrome (PICS) and question whether current approaches are capturing the outc...

11 Touko 23min

Redefining Precision Nutrition: Where Science Meets the patient’s bedside

Redefining Precision Nutrition: Where Science Meets the patient’s bedside

In this episode of the educational podcast, we explore what precision nutrition truly means in intensive care. While the concept is widely discussed in research, many studies remain descriptive or rel...

8 Huhti 31min

Why does renal recovery from AKI matter to us intensivists?

Why does renal recovery from AKI matter to us intensivists?

Acute Kidney Injury (AKI) is a frequent complication in critically ill patients and is associated with significant morbidity and mortality. However, the clinical relevance of AKI extends well beyond t...

18 Maalis 24min

Kids visitations in the ICU. Ten recommendations for child-friendly visiting policies in critical care

Kids visitations in the ICU. Ten recommendations for child-friendly visiting policies in critical care

21 Touko 202528min

Suosittua kategoriassa Liike-elämä ja talous

sijotuskasti
psykopodiaa-podcast
mimmit-sijoittaa
rss-oivalluksia-rahasta-elamasta
ostan-asuntoja-podcast
asuntoasiaa-paivakirjat
rss-rahapodi
rahapuhetta
oppimisen-psykologia
pomojen-suusta
rss-rahamania
rss-hilden-kaira-podcast
rss-inderes
inderespodi
kasvun-kipuja
hyva-paha-johtaminen
juristipodi
raharesepti
rss-markkinointitrippi
rss-tarkeista-asioista-2