112 | Fyodor Urnov on Gene Editing, CRISPR, and Human Engineering

112 | Fyodor Urnov on Gene Editing, CRISPR, and Human Engineering

Not too long ago nobody carried a mobile phone; now almost everybody does. That's the kind of rate of rapid progress we're seeing with our ability to directly edit genomes. With the use of CRISPR-Cas9 and other techniques, gene editing is becoming commonplace. How does that work — and perhaps more importantly, how are we going to put it to use? Fyodor Urnov has worked in this area from its beginning, having coined the term "gene editing." We talk about how this new technology can be used to cure or prevent disease, as well as the pros and cons of designer babies.

Support Mindscape on Patreon.

Fyodor Urnov received his Ph.D. in Biology from Brown University. He is currently professor of Genetic, Genomics, and Development in the Department of Molecular and Cell Biology at UC Berkeley, as well as Director for Technology and Translation at the Innovative Genomics Institute. His research focuses on using CRISPR gene-editing techniques to develop treatments for sickle cell disease, radiation injury, and other conditions, as well as guiding IGI researchers as they bring these therapies from the lab to the clinic.

Todays episode is sponsored by The Great Courses Plus. Mindscape listeners get a free trial if they sign up at http://thegreatcoursesplus.com/mindscape.

Jaksot(415)

314 | Karen Lloyd on the Deep Underground Biosphere

314 | Karen Lloyd on the Deep Underground Biosphere

There are living creatures dwelling deep below the surface of the Earth, as deep as we are able to drill. These hearty microorganisms are related to more familiar life forms on land and under water, b...

12 Touko 20251h 9min

313 | Eric Topol on the Changing Face of Medicine and Aging

313 | Eric Topol on the Changing Face of Medicine and Aging

Medical science is advancing at an astonishing rate. Today we talk with leading expert Eric Topol about two aspects of this story. First, the use of artificial intelligence in medicine, especially in ...

5 Touko 20251h 12min

AMA | May 2025

AMA | May 2025

Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

28 Huhti 20253h 38min

312 | Thomas Levenson on the Mutual History of Humans and Germs

312 | Thomas Levenson on the Mutual History of Humans and Germs

The germ theory of disease is a crowning achievement of science, up there with modern physics, continental drift, and evolution via natural selection. (Even if there will always be cranky skeptics.) B...

21 Huhti 20251h 31min

311 | Annaka Harris on Whether Consciousness is Fundamental

311 | Annaka Harris on Whether Consciousness is Fundamental

Questions about consciousness range from the precise and empirical -- what neurons fire when I have some particular experience -- to the deeply profound -- does consciousness emerge from matter, or do...

14 Huhti 20251h 10min

AMA | April 2025

AMA | April 2025

Welcome to the April 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

7 Huhti 20253h 30min

310 | Marc Kamionkowski on Dark Energy and Cosmic Anomalies

310 | Marc Kamionkowski on Dark Energy and Cosmic Anomalies

Cosmologists were, let us be honest, pretty stunned in 1998 when observations revealed that the universe is accelerating. There was an obvious plausible explanation, the cosmological constant proposed...

31 Maalis 20251h 26min

309 | Christof Koch on Consciousness and Integrated Information

309 | Christof Koch on Consciousness and Integrated Information

Consciousness is easier to possess than to define. One thing we can do is to look into the brain and see what lights up when conscious awareness is taking place. A complete understanding of this would...

24 Maalis 20251h 20min

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