117 | Sean B. Carroll on Randomness and the Course of Evolution

117 | Sean B. Carroll on Randomness and the Course of Evolution

Evolution is a messy business, involving as it does selection pressures, mutations, genetic drift, and the effects of random external interventions. So in the end, how much of it is predictable, and how much is in the hands of chance? Today we're thrilled to have as a guest my evil (but more respectable, by most measures) twin, the biologist Sean B. Carroll. Sean is both a leader of the modern evo-devo revolution, and a wonderful and diverse writer. We talk about the importance of randomness and unpredictability in life, from the evolution of species to the daily routine of every individual.

Support Mindscape on Patreon.

Sean B. Carroll received a Ph.D. in immunology from Tufts University. He is currently the Andrew and Mary Balo and Nicholas and Susan Simon Endowed Chair of Biology at the University of Maryland, Vice-President for Science Education at the Howard Hughes Medical Institute, the Executive Director of HHMI Tangled Bank Studios, and Professor Emeritus of Genetics and Molecular Biology at the University of Wisconsin. His new book, A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You, explores the role of chance in the development of life.


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354 | Christian List on Free Will and Levels of Reality

354 | Christian List on Free Will and Levels of Reality

Did I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. To...

18 Touko 1h 26min

353 | Alvin Roth on the Economics of Morally Contested Markets

353 | Alvin Roth on the Economics of Morally Contested Markets

Economic markets are efficient ways of deciding fair prices, at least in ideal circumstances of perfect competition, information, and choice. But there is more to life than fair prices. Two people mig...

11 Touko 1h 11min

AMA | May 2026

AMA | May 2026

Welcome to the May 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

4 Touko 4h 6min

352 | Bing Brunton on Connecting the Connectome to the Body

352 | Bing Brunton on Connecting the Connectome to the Body

The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long ...

27 Huhti 1h 14min

351 | Peter Singer on Maximizing Good for All Sentient Creatures

351 | Peter Singer on Maximizing Good for All Sentient Creatures

Peter Singer has been an influential philosopher for a number of decades. He was a significant early voice in animal rights, has been a leading thinker of utilitarianism, and helped inspire the effect...

20 Huhti 1h 15min

350 | J. Eric Oliver on the Self and How to Know It

350 | J. Eric Oliver on the Self and How to Know It

We are more familiar with ourselves than with anything else in the universe, but we generally don't come very close to really understanding what our "self" is. That's not too surprising, as selves are...

13 Huhti 1h 21min

AMA | April 2026

AMA | April 2026

Welcome to the April 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

5 Huhti 3h 46min

349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics

349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics

There is something special about gravity. After decades of effort, there is still no convergence on the right way to reconcile Einstein's theory of general relativity with the framework of quantum mec...

30 Maalis 1h 25min

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