117 | Sean B. Carroll on Randomness and the Course of Evolution

117 | Sean B. Carroll on Randomness and the Course of Evolution

Evolution is a messy business, involving as it does selection pressures, mutations, genetic drift, and the effects of random external interventions. So in the end, how much of it is predictable, and how much is in the hands of chance? Today we're thrilled to have as a guest my evil (but more respectable, by most measures) twin, the biologist Sean B. Carroll. Sean is both a leader of the modern evo-devo revolution, and a wonderful and diverse writer. We talk about the importance of randomness and unpredictability in life, from the evolution of species to the daily routine of every individual.

Support Mindscape on Patreon.

Sean B. Carroll received a Ph.D. in immunology from Tufts University. He is currently the Andrew and Mary Balo and Nicholas and Susan Simon Endowed Chair of Biology at the University of Maryland, Vice-President for Science Education at the Howard Hughes Medical Institute, the Executive Director of HHMI Tangled Bank Studios, and Professor Emeritus of Genetics and Molecular Biology at the University of Wisconsin. His new book, A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You, explores the role of chance in the development of life.


Jaksot(415)

327 | Cass Sunstein on Liberalism

327 | Cass Sunstein on Liberalism

"Liberalism," divorced from its particular connotations in this or that modern political context, refers broadly to a philosophy of individual rights, liberties, and responsibilities, coupled with res...

1 Syys 20251h 10min

326 | Natalie Batalha on What We Know and Will Learn About Exoplanets

326 | Natalie Batalha on What We Know and Will Learn About Exoplanets

In a relatively short period of time, exoplanets (planets around stars other than our Sun) have gone from an intriguing conjecture to an active field of scientific study, with over 5,000 confirmed dis...

25 Elo 20251h 12min

325 | Alvy Ray Smith on Pixar, Pixels, and the Great Digital Convergence

325 | Alvy Ray Smith on Pixar, Pixels, and the Great Digital Convergence

The world is becoming pixelated. As computers and other digital devices become ubiquitous, human knowledge and communication and information is gradually being converted into, and manipulated as, stri...

18 Elo 20251h 26min

324 | Elizabeth Mynatt on Universities and the Importance of Basic Research

324 | Elizabeth Mynatt on Universities and the Importance of Basic Research

It is not manifestly obvious that universities should be where most scholarly research is performed. One could imagine systems that separated out the tasks of "teaching students" and "generating new k...

11 Elo 20251h 13min

AMA | August 2025

AMA | August 2025

Welcome to the August 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patr...

4 Elo 20253h 39min

323 | Jacob Barandes on Indivisible Stochastic Quantum Mechanics

323 | Jacob Barandes on Indivisible Stochastic Quantum Mechanics

The search for a foundational theory of quantum mechanics that all physicists can agree on remains active. Over the last century a number of contenders have emerged, including Many-Worlds, pilot-wave ...

28 Heinä 20252h 58min

322 | Philip Pettit on Language, Agency, Politics, and Freedom

322 | Philip Pettit on Language, Agency, Politics, and Freedom

When we think of the capacities that distinguish humans from other species, we generally turn to intelligence and its byproducts, including our technological prowess. But our intelligence is highly co...

21 Heinä 20251h 20min

321 | David Tong on Open Questions in Quantum Field Theory

321 | David Tong on Open Questions in Quantum Field Theory

Quantum field theory is the basis for our most successful theories of fundamental physics. And yet, there are things we don't understand about it. Some of these puzzles are relatively well-known, whil...

14 Heinä 20251h 19min

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