Breakpoints25 Loka 2024

#105 – Bringing Positive Vibes Only: Breaking News & Emerging Hypotheses for Gram-Positive Bacterial Infections

Drs. Cesar Arias (@SuperBugDoc) and Katie Barber join Dr. Julie Ann Justo (@julie_justo) to discuss what is hot-off-the-presses for gram-positive bacterial infections and it’s a total party vibe! They review the latest news for recent and ongoing clinical trials (DOTS, DISRUPT, and SNAP trials), discuss hope for novel clinical tests of the cefazolin inoculum effect in staphylococci, and explore the fascinating changes in virulence and potential therapeutic options for the most challenging enterococci.

Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp

References

Climate Change and Antimicrobial Resistance. Editors in Conversation Podcast. American Society for Microbiology. Oct 2023.
Is More Better? The Role of Combination Therapy for MRSA. Breakpoints Podcast Episode #30. Society of Infectious Diseases Pharmacists.
Turner NA, et al. DOTS: Dalbavancin as an Option for Treatment of Staphylococcus aureus Bacteremia. ESCMID Global 2024. April 2024. NCT04775953.
Real-world dalbavancin observational cohort: Rebold N, et al. Infect Dis Ther. 2024 Mar;13(3):565-579. doi: 10.1007/s40121-024-00933-2. PMID: 38427289.
Exebacase DISRUPT trial : Fowler VG Jr, et al. Clin Infect Dis. 2024 Jun 14;78(6):1473-1481. doi: 10.1093/cid/ciae043. PMID: 38297916.
@snap_trial tweet of Breaking News. Aug 2024.
Investigator Resources for the SNAP trial. Sept 2024: https://www.snaptrial.com.au/for-investigators#interim
Cefazolin inoculum effect on mortality in MSSA bacteremia : Miller WR, et al. Open Forum Infect Dis. 2018 May 23;5(6):ofy123. doi: 10.1093/ofid/ofy123. PMID: 29977970.
Prevalence of cefazolin inoculum effect in MSSA and modified rapid nitrocefin test for detection: Carvajal LP, et al. Antimicrob Agents Chemother. 2024 Sep 30:e0089824. doi: 10.1128/aac.00898-24. PMID: 39345182.
LiaX as surrogate for cell envelope stress in Enterococus faecium: Axell-House DB, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106923. doi: 10.1128/aac.01069-23. PMID: 38289081.
Shorter is better for uncomplicated streptococcal bacteremia: Clutter DS, et al. Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0022024. doi: 10.1128/aac.00220-24. PMID: 38975753.
Short vs. long antibiotic duration in Streptococcus pneumoniae bacteremia: Crotty M, et al. Open Forum Infect Dis. 2024 Aug 30;11(9):ofae478. doi: 10.1093/ofid/ofae478. PMID: 39257675.

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#22 – Taking a “BITE” Out of Antibiotic Prescribing: The Need for Antimicrobial Stewardship in Dentistry

Dr. Katie Suda (@sudamonas) and Dr. Erinne Kennedy join Dr. Zahra Escobar (@zkepharmd) of the Breakpoints team to discuss why dentists prescribe 1 in 10 of all antibiotics in the United States and how...

15 Touko 202037min

#21 – Frontline Allies: Emergency Medicine and Critical Care Insights into COVID19

Dr. Jenny Koehl (@jlkoehl), Dr. Karen Berger (@karenccrx), and Dr. Karen Dohr join host Erin McCreary (@erinmccreary) to discuss taking care of patients with COVID-19 in the Emergency Department and I...

27 Huhti 20201h 1min

#20 – What is Happening Right Now? COVID-19 Challenges and Silver Linings

Julie Ann Justo (@julie_justo), Jason Pogue (@jpogue1), and Erin McCreary (@erinmccreary) discuss critically evaluating COVID-19 literature, staying calm in the storm, strategies for team education an...

13 Huhti 20201h 1min

#19 – Push and Pull: Combating Antibiotic Resistance from Discovery to Market Reform

Dr. Mike Dudley (@MikeMndudley), President and CEO of Qpex Biopharma, joins Dr. Erin McCreary (@erinmccreary) to discuss the thrills and failures of antibiotic discovery and development along with the...

21 Helmi 20201h 24min

#18 – Waking the Sleeping Giant: Engaging Nurses in Antimicrobial Stewardship

Dr. David Ha (@DHpharmd) interviews Dr. Rita Olans (@RitaOlans) and Dr. Elizabeth Monsees (@eamonsees) about the critical role nurses play in antimicrobial stewardship. They discuss how nursing practi...

17 Tammi 202046min

#17 – See C. diff: A Discussion on Patient Advocacy

Christian John Lillis, co-founder and Executive Director of the Peggy Lillis Foundation (@peggyfund), joins Erin McCreary (@erinmccreary) to share his mother’s story and discuss opportunities and chal...

20 Joulu 20191h 15min

#16 – 5 Ways Hospital Pharmacists Can Be Antibiotics Aware

Dr. Susan Davis (@IDPharmProf) and Dr. Jason Pogue (@jpogue1) celebrate Antibiotic Awareness Week by discussing the 5 Ways Hospital Pharmacists Can Be Antibiotics Aware, including: verify penicillin a...

20 Marras 201948min

#15 – CDC Core Elements of Hospital Antibiotic Stewardship Programs: 2019 Update

Dr. Arjun Srinivasan and Dr. Melinda Neuhauser join host Dr. Erin McCreary (@erinmccreary) to discuss the updated Core Elements of Hospital Antibiotic Stewardship Programs from the Centers for Disease...

18 Marras 201953min