Breakpoints25 Loka 2024

#105 – Bringing Positive Vibes Only: Breaking News & Emerging Hypotheses for Gram-Positive Bacterial Infections

Drs. Cesar Arias (@SuperBugDoc) and Katie Barber join Dr. Julie Ann Justo (@julie_justo) to discuss what is hot-off-the-presses for gram-positive bacterial infections and it’s a total party vibe! They review the latest news for recent and ongoing clinical trials (DOTS, DISRUPT, and SNAP trials), discuss hope for novel clinical tests of the cefazolin inoculum effect in staphylococci, and explore the fascinating changes in virulence and potential therapeutic options for the most challenging enterococci.

Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp

References

Climate Change and Antimicrobial Resistance. Editors in Conversation Podcast. American Society for Microbiology. Oct 2023.
Is More Better? The Role of Combination Therapy for MRSA. Breakpoints Podcast Episode #30. Society of Infectious Diseases Pharmacists.
Turner NA, et al. DOTS: Dalbavancin as an Option for Treatment of Staphylococcus aureus Bacteremia. ESCMID Global 2024. April 2024. NCT04775953.
Real-world dalbavancin observational cohort: Rebold N, et al. Infect Dis Ther. 2024 Mar;13(3):565-579. doi: 10.1007/s40121-024-00933-2. PMID: 38427289.
Exebacase DISRUPT trial : Fowler VG Jr, et al. Clin Infect Dis. 2024 Jun 14;78(6):1473-1481. doi: 10.1093/cid/ciae043. PMID: 38297916.
@snap_trial tweet of Breaking News. Aug 2024.
Investigator Resources for the SNAP trial. Sept 2024: https://www.snaptrial.com.au/for-investigators#interim
Cefazolin inoculum effect on mortality in MSSA bacteremia : Miller WR, et al. Open Forum Infect Dis. 2018 May 23;5(6):ofy123. doi: 10.1093/ofid/ofy123. PMID: 29977970.
Prevalence of cefazolin inoculum effect in MSSA and modified rapid nitrocefin test for detection: Carvajal LP, et al. Antimicrob Agents Chemother. 2024 Sep 30:e0089824. doi: 10.1128/aac.00898-24. PMID: 39345182.
LiaX as surrogate for cell envelope stress in Enterococus faecium: Axell-House DB, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106923. doi: 10.1128/aac.01069-23. PMID: 38289081.
Shorter is better for uncomplicated streptococcal bacteremia: Clutter DS, et al. Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0022024. doi: 10.1128/aac.00220-24. PMID: 38975753.
Short vs. long antibiotic duration in Streptococcus pneumoniae bacteremia: Crotty M, et al. Open Forum Infect Dis. 2024 Aug 30;11(9):ofae478. doi: 10.1093/ofid/ofae478. PMID: 39257675.

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#14 – Pumpkin-Spiced Lessons: Phages, Posters, and Paul Sax

Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) are joined by Dr. Paul Sax (@PaulSaxMD) to review important updates in HIV care from IDWeek 2019. They also go “rapid fire” through poste...

8 Marras 20191h 15min

#13 – Provocative Titles and Pro-Con Debates

Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) discuss the IDWeek 2019 session "We're Part of the Problem: How ID Killed Antibiotic Development' and other hot topics including pro-con ...

8 Marras 20191h 5min

#12 – Late Breaker Trials and #WhyIVaccinate

Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) share some big announcements from IDWeek 2019 including the #WhyIVaccinate movement, data from late-breaking clinical trials, new partner...

1 Marras 201957min

#11 – Practice-changing Publications ft. David van Duin

Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) are joined by Dr. David van Duin (@davidvanduin) to review “Clinical Trials That Might Change Your Practice” in bacteriology, virology, a...

1 Marras 201952min

#10 – So You're an Antimicrobial Steward... Now What?

Host Erin McCreary (@erinmccreary) and expert panelists Libby Dodds Ashley (@The_Real_LDA), Lisa Dumkow (@LisaIDpharmD), and Jamie Kisgen (@KisgenUF) share real-world experiences in order to empower n...

31 Heinä 201931min

#9 – Show Me the Data!

Host Erin McCreary (@erinmccreary) and expert panelists Libby Dodds Ashley (@The_Real_LDA), Lisa Dumkow (@LisaIDpharmD), and Jamie Kisgen (@KisgenUF) discuss how to market your stewardship program, wi...

31 Heinä 201935min

#8 – Stewardship is a Team Sport

Journey with host Erin McCreary (@erinmccreary) and expert panelists Libby Dodds Ashley (@The_Real_LDA), Lisa Dumkow (@LisaIDpharmD), and Jamie Kisgen (@KisgenUF) through their lessons learned and fav...

31 Heinä 201934min

#7 – Rapid Fire Data from ECCMID 2019

Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) go “rapid fire” through posters and oral abstracts presented at ECCMID 2019, including: rapid diagnostics, the influence of leadership in...

10 Heinä 201935min