Episode #288: Connie Zack: Infrared Insights: From Heavy Metal Detox to Cardiovascular Health

If there is one thing that humanity has been striving for since its inception, is the pursuit of longevity. Today I’m with Chris Mirabile, Founder & CEO of NOVOS Labs who brings us one step closer to cracking the code of aging and longevity and offers fascinating insight into the intersection of health, performance, and longevity. We discuss how short-term health strategies may not always contribute positively to longevity, and the nine hallmarks of aging that NOVOS Labs aims to address. These include loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening.    Chris’s interest in health began when he was 12 and evolved into a passion after he was cured of a brain tumor when he was 16. Chris has researched and integrated longevity practices and interventions into his life for more than ten years, has achieved a biological age 13.6 years younger than his chronological age, and according to epigenetic tests like DunedInPACE, is aging 31% slower biologically than chronologically. As we dive deeper into the realm of aging and anti-aging strategies, we bring ourselves one step closer to a future where longevity is not just a dream, but a reality.   Chris Mirabile graduated from NYU Stern School of Business and later won their business plan competition with his startup company, Hotlist, a location-based social network that scaled to 220 million people’s social plans. Chris has launched multiple successful technology ventures and has advised biotech startups and NYU Langone Hospital.    Vist novoslabs.com and use code NAT5 to save.   Thank you to our sponsors for making this episode possible: BiOptimizers: Use code bionat10 at magbreakthrough.com/bionat  LMNT: Visit DrinkLMNT.com/NAT - no code needed Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Chris: Instagram: instagram.com/slowmyage/ Twitter: twitter.com/slowmyage Website: slowmyage.com   What we discuss: (0:03:00) - The Short-Term Health vs. Longevity Dilemma (0:10:34) - Balancing Strategies for Longevity (0:19:29) - Aging and Anti-Aging Formulations (0:28:32) - Autophagy and Microbiome in Aging (0:39:26) - Understanding Senescent Cells-Safest Approach (0:53:55) - Comparing Different Aging Clocks   Key takeaways: Aging and longevity are complex processes with numerous factors at play, such as loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening.  Senescent cells, while often perceived negatively due to their contribution to aging, can also play beneficial roles in certain contexts such as wound healing and limiting fibrosis. However, current senolytics can pose risks due to potential toxicity and lack of precision in targeting the right cells. While strategies such as severe caloric restriction or prolonged fasting can contribute to longevity, they may also have detrimental effects on short-term health and performance. It's crucial to strike a balance and consider the long-term implications of these health strategies. The ideal time to start implementing longevity strategies, like Novos, is around late 20s to early 30s.

28 Marras 20231h 25min

What happens to your gut health when you take antibiotics?   In this episode of the Biohacking Superhuman Performance podcast, we chat with Colleen Cutcliffe of Pendulum Life about the effects of our gut microbiome on our mental health, metabolism, energy levels, and learn to pinpoint signs of compromised gut health.   Colleen dissects the nuances of probiotics, prebiotics, postbiotics, and synbiotics, and how these elements interact in our gut. Additionally, we examine the often-underestimated impact of antibiotics on our microbiome and how it can be combated with effective strategies.   Lastly, we shift our focus to a specific strain of bacteria, known as akkermansia, and explore their role in food metabolism and mood regulation. In the same vein, we contemplate on the potential risks of long-term drug use including GLP-1, and delve into the impact of metformin on gut health.    Colleen Cutcliffe is the CEO and Co-Founder of Pendulum Therapeutics. Colleen has over 20 years of experience managing and leading teams in biotech, pharma and academia. Prior to that, Colleen was a Scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral research at Northwestern’s Children’s Memorial Hospital, received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and received her B.A. in Biochemistry from Wellesley College.   Thank you to our sponsors for making this episode possible:   Healthgevity: Go to healthgev.com and use code LONGEVITY to save. Berkeley Life: Go to berkeleylife.com and use code NIDDBL to save. LVLUP: Go to lvluphealth.com and use code NAT10 for 10% off your order. Find more from Nathalie:   YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  Instagram: https://www.instagram.com/nathalieniddam/  Website: NatNiddam.com   Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Colleen:   Website: https://pendulumlife.com/  Facebook: https://www.facebook.com/PendulumLife  Instagram: https://www.instagram.com/pendulumlifeco/  Linkedin: https://www.linkedin.com/company/pendulumco/  Twitter: https://twitter.com/Pendulum_Co  What we discuss:   (00:02) - Gut Health and Mental Health Connection (07:43) - Understanding Gut Health and Microbiome Terminology (19:16) - The Battle of Diets and Nutrition (26:37) - Antibiotics' Impact on Microbiome and Rebalancing Strategies (35:37) - Gut Microbiome and Healthy Aging (44:30) - Risks of Long-Term Antibiotic Use (58:39) - Benefits and Challenges of Akkermansia  (01:04:49) - Live Probiotics and Colonization Importance   Key takeaways:   Nutrition is an important part of gut health. However, there isn’t a particular diet that will make or break your gut health nor can you eat a nutrient-poor diet and expect probiotic supplements to keep your gut microbiome in good shape. Simply aiming to eat a balanced, nutrient rich diet is the way to go. While antibiotics have a negative impact on your gut health, it does come with a plus side. Given that antibiotics eliminate all bacteria – good and bad – the timeframe following an antibiotic treatment is a great time to focus on fixing your diet so you can repopulate your gut microbiome with the appropriate strains. While many of us blame our poor willpower for our cravings, it’s usually our gut microbiome that is to blame. Luckily, there are specific strains one can supplement to help increase GLP-1 and GABA production to stimulate satiety and reduce anxiety, which helps reduce cravings overall.

24 Marras 20231h 23min

Ever grappled with sleeplessness or tossed and turned all night, cursing your 'bad sleeper' status? Well, you're not alone.    In this episode of the Biohacking Superhuman Performance podcast, our guest Mollie Eastman shares her techniques of adopting a growth mindset towards sleep and talks about the various factors that can affect our sleep cycle. She stresses on the importance of understanding our individual relationship with sleep and how it can be worked upon, just like any other skill.   Our conversation further delves into the long-term impacts of poor sleep and the correlation it has with various health disorders. Particularly for those working late-night shifts or struggling with time zone changes, the episode offers comprehensive resources to help mitigate the impacts. We discuss the use of various sleep tracking tools, the relevance of meal timings, and the effects of blue light exposure. We also touch upon the negotiation tactics that can be used with employers to minimize the negative impacts of shift work. Finally, we explore sleep apnea - its symptoms, treatments, and the significance of seeking professional help.    Mollie Eastman is the creator of Sleep Is A Skill, and the host of The Sleep Is A Skill Podcast. Sleep Is A Skill is a company that optimizes people’s sleep through a unique blend of technology, accountability, and behavioral change.  She has created the #2 sleep podcast, written a popular weekly sleep newsletter for over five years, partnered with luxury hotels & lifestyle brands, coached the world’s top poker players, and has appeared on over 150 podcasts.    Thank you to our sponsors for making this episode possible: BiOptimizers: Visit magbreakthrough.com/bionat and order now. LeelaQ: Go to www.leelaq.com and use the code NATHALIE10. Profound Health: Use code longevity15 to save 15% off your first order at www.profound-health.com. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  Instagram: https://www.instagram.com/nathalieniddam/  Website: NatNiddam.com   Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Mollie:   Website: https://www.sleepisaskill.com/ Sleep Is A Skill Podcast: https://www.sleepisaskill.com/podcasts Instagram: https://www.instagram.com/mollie.eastman What we discuss:   (0:00:03) - Importance of Sleep as a Skill (0:10:04) - Shift Work's Impact on Sleep (0:22:30) - Improving Sleep for Shift Workers (0:28:26) - Importance of Sleep Professionals in Sleep Apnea (0:35:39) - Sleep Apnea Treatment and Improving Sleep (0:48:19) - Improving Sleep With Skill Key takeaways:   Sleep impacts every single domain of life. This means having poor sleep quality may increase your risk of cardiovascular disease, cognitive decline, weight gain, and so much more. Thus, the importance of developing the skill of becoming a better sleeper.  Sleep apnea can be caused by a handful of factors and is not only due to someone’s sleep positions. This could be caused by foods we eat, at what time we eat, alcohol, weight gain, and much more. Humans are naturally meant to sleep at night and be awake during the day. Thus, shift work may cause harm to your health. Knowing how to adapt your sleeping patterns so they fit your professional schedule will prevent you from dealing with the negative consequences of staying up at night.

21 Marras 20231h 3min

Do you have trouble getting a good night’s sleep when traveling?   In this bonus episode of the Biohacking Superhuman Performance podcast,  I share some practical tips and travel hacks to help you maintain optimal health and sleep while on the go. From using a Sleep Crown pillow and silk eye mask to block out light and noise, to carrying a roll of black electrical tape for those pesky room lights, these tools can make a huge difference in your travel sleep experience.    I also share my strategies for combating the negative effects of travel, including blue blockers and sleep supplements, among other things. Lastly, I'll introduce you to some of my favorite personal care and travel products.   Thank you to our sponsors for making this episode possible:   Restoracell: Use code NAT25 at www.vitaliskincare.com Find more from Nathalie:   YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   What we discuss:   (00:09) - Travel Hacks for Better Sleep (08:24) - Travel Essentials for Optimal Well-Being (21:19) - Personal Care and Travel Product Recommendations

17 Marras 202331min

Ever wondered how the intricate world of Silicon Photonics can intersect with health markers? We roped in someone who knows it all - Michael Dubrovsky, co-founder and chief product officer of SiPhox. this episode of the Biohacking Superhuman Performance podcast is an intriguing journey that unwraps the science of miniaturizing optics onto silicon chips and the dynamics of launching a company that aims to bring lab-like precision into the comfort of our homes.   Michael discusses the importance of tracking inflammation, understanding the significance of the CRP test , and the impact that workouts, flights, lifestyle and supplements can have on our CRP levels. As we proceed, we unveil the potential of simple lifestyle changes to improve metabolic and cardiovascular health. We also peek into the future of home blood testing and the role of semiconductor technology in driving this forward.    Michael is the co-founder and CPO of SiPhox. He not only engineered this device alongside his co-founder Diedrik Vermeulen and their team of scientists but also leads our current direct-to-consumer venture (as the SiPhox Home device is not FDA-cleared yet), a 17-biomarker comprehensive health test at the lowest price on the market in US and Canada.  Michael is an engineer, a serial entrepreneur, and a tech investor.    To learn more or to order your own Home Test Go to https://siphoxhealth.com/superhuman and use code NAT10  to save. Thank you to our sponsors for making this episode possible: Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition. LMNT: Visit DrinkLMNT.com/NAT - no code needed Berkeley Life: Use code NIDDBL at www.berkeleylife.com   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  Instagram: https://www.instagram.com/nathalieniddam/  Website: NatNiddam.com   Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Michael: Website: ​​https://siphoxhealth.com/  Instagram: https://www.instagram.com/andreadonsky/  What we discuss:   (0:00:03) - Silicon Photonics and Health Markers (0:06:06) - Understanding CRP Tests and Inflammation Control (0:20:14) - Exploring Health Hacks and Inflammatory Markers (0:25:21) - Blood Testing, Supplements, and CGM Monitoring (0:34:40) - New Technology for Home Blood Testing (0:43:01) - Iron Levels and Aging Biomarkers Key takeaways:   The C-reactive protein (CRP) test is used to find inflammation in your body. Scientists have found that levels of CRP correlate with changes in inflammation, disease activity, tissue damage, and more. This is a key marker to track for health and longevity.  The standard ranges in the medical field for different markers may be completely different from what is considered healthy in the functional medicine field. For example, insulin numbers in the functional field are considered healthy between the 7 to 10 range, while up to 24.9 is considered the standard range in the medical field.

14 Marras 20231h 8min

Do women really have no other option than to tough out the symptoms of perimenopause and menopause?    In this episode of the Biohacking Superhuman Performance podcast, we chat with Andrea Donsky about the top symptoms of menopause and perimenopause, such as fatigue, brain fog, and sleep issues. The conversation then shifts to diet, lifestyle, and supplement choices women can make to maintain their health and vitality during this period. Andrea's insights into the benefits of strength training, stress management, and balanced nutrition are particularly informative and encouraging.   The episode concludes with an in-depth discussion on the importance of sleep and exercise during menopause. Andrea highlights how these factors contribute to overall well-being and bone health.    Andrea Donsky is a Nutritionist on a mission to change the conversation around perimenopause and menopause. An entrepreneur with more than 23 years of experience in the health and wellness industry, Andrea is a respected Multiple-Award-Winning Influencer, Media Personality, Speaker, and Author. Andrea also hosts the weekly ‘Menopause Reimagined’ podcast, and appears as a Menopause Expert on television across North America. To date, Andrea has appeared in over 450 TV segments and has been featured on every major network across the U.S and Canada. Thank you to our sponsors for making this episode possible:   Neurohacker:  Visit neurohacker.com/NATHALIE and use the code NATHALIE  Carol Bike: Visit carolbike.com and use promo code NAT for $100 off. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie:   YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  Instagram: https://www.instagram.com/nathalieniddam/  Website: NatNiddam.com   Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Andrea:   Website: http://wearemorphus.com/  Instagram: https://www.instagram.com/andreadonsky/  What we discuss:   (0:00:03) - Exploring Menopause and Women's Health (0:11:30) - Menopause's Impact on Women's Symptoms (0:16:37) - Perimenopause and Menopause Symptoms (0:20:27) - Navigating Change and Finding Balance (0:23:47) - Nutrition and Wellness in Menopause (0:30:28) - Understanding Sleep Issues in Midlife (0:42:41) - The Importance of Sleep and Exercise (0:45:20) - Strength Training for Women's Health (0:50:08) - Women's Health and Supplement Recommendations (0:58:23) - Preparing for Menopause (1:01:49) - Social Media Presence and Community Engagement Key takeaways: During menopause, some women may experience various symptoms such as hot flashes, night sweats, mood swings, and weight gain. While there is no one-size-fits-all approach to managing menopausal symptoms through diet, there are certain foods and/ or ingredients that may exacerbate these symptoms for some women and should be avoided.  Sleep disruptions are a common symptom experienced by many women during menopause. Three factors which contribute to these sleep disturbances include hormonal changes, hot flashes and night sweats, stress and lifestyle factors, and having to go to the bathroom more often. Weight-lifting is crucial in this stage of life. Women  are at risk of losing muscle mass and strength due to hormonal changes. Resistance training helps counteract muscle loss, which can lead to improved functional capacity and overall physical well-being.

7 Marras 20231h 13min

Think you can’t lose weight without GLP1 agonists?   Think again. In this solo episode of the Biohacking Superhuman Performance podcast, we bypass common drugs like GLP1 agonists, including OZMPIC, and discuss safer and effective alternatives. You will get insights into muscle loss mitigation during dramatic weight loss, and discover other innovative fat loss strategies that steer clear of the potential risks associated with miracle weight loss drugs.   We also talk about microbiome and weight loss probiotics, with a focus on Akkermansia, a bacterial strain associated with lean individuals. I share my experience with DNF-10, a peptide that is known to significantly lower ghrelin secretion before meals, and contributes to maintaining the release of leptin from adipocytes.    Lastly, we discuss the importance of living a healthy lifestyle, as Akkermansia and DNF-10 may be a piece of the puzzle, but they are not a magic solution for weight loss.      Thank you to our sponsors for making this episode possible:   Apollo: Go to apolloneuro.com/nat and use code NAT50 to save $50 Restoracell: Use code NAT25 at www.vitaliskincare.com Find more from Nathalie:   YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   What we discuss:   (00:09) - Alternative Approaches to Weight Loss (09:20) - Effective Eating Plans and Innovative Products (14:31) - Weight Loss and Fat Burning Formulas (21:52) - Microbiome and Weight Loss Probiotics

3 Marras 202331min

What if there was a magical potion for enhanced energy?   In this episode of the Biohacking Superhuman Performance podcast, Dr. John Lieurance Venture walks us through the evolution of regenerative medicine, from the simplest form of cod liver oil to the innovative treatments of today. Dr. Lieurance enlightens us on the wonders of platelet-rich plasma, exosomes, bone marrow stem cells, and how they can speed up the healing process and enhance overall health. What's more, we dive into the power of V cells, and how they can work in conjunction with these treatments for greater healing efficiency.   We also delve deeper into the world of methylene blue and melatonin, exploring their diverse applications from suppressing microbial replication to boosting mitochondrial activity. Lastly, we the alchemy of combining methylene blue and melatonin, forming a 'magical potion' for enhanced energy and depression aid.    Dr. John Lieurance, a renowned Chiropractic Neurologist with over 22 years of experience in Sarasota, has gained significant attention for his groundbreaking Functional Cranial Release (FCR) procedure. He masterfully blends therapies that address the three pivotal pillars: Identity, Divinity, and Vitality.  Beyond FCR, Dr. Lieurance's holistic approach to health and wellness is evident in his dedication to his craft, which extends beyond his clinic at Advanced Rejuvenation. He also travels globally, imparting his knowledge to other medical professionals.    Visit https://www.mitozen.club/ and use code NAT10 to save 10%. Thank you to our sponsors for making this episode possible: LeelaQ: Go to www.leelaq.com and use code NATHALIE10  Carol Bike: Visit carolbike.com and use promo code NAT for $100 off. Mitopure: Use code NAT10 for 10% off at www.timelinenutrition.com/shop/nutrition   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. John Lieurance: Website: https://www.drjohnlieurance.com/ and https://www.mitozen.club/  Instagram: https://www.instagram.com/drjohnlieurance/  What we discuss: (00:00) - Healing Clinic and Patient Demographics (10:32) - Regenerative Medicine and Joint Healing (16:50) - Stem Cells and Future Medicine (29:03) - V Cells and GHK Copper Peptide Applications (37:31) - Magnesium IV With Methylene Blue (44:51) - The Versatility of Methylene Blue (48:22) - Methylene Blue and Suppository Delivery (53:10) - Methylene Blue and Melatonin (01:05:05) - Discussion on Melatonin and Its Effects (01:11:40) - Benefits of Melatonin Supplementation (01:18:13) - Sun Exposure, Skin Color, and Products (01:21:10) - Methylene Blue, NAD, and Suppositories (01:34:35) - Liposomal Melatonin Benefits and Discount Key takeaways: Inflammation is oftentimes the culprit to the health issues we are experiencing. Thus, finding the cause of this inflammation in the body is the first step to healing. Afterwards, turning to regenerative medicine is key for undoing the damage caused by the inflammation. Excessive nitric oxide production, often in response to inflammation, can lead to oxidative stress and damage to brain cells. This oxidative stress is believed to contribute to the development of depression and other mood disorders. Research has demonstrated that B cells play a role in tissue repair and remodeling by secreting factors that influence inflammation, fibrosis, and regeneration. Thus, if you are experiencing inflammation in the lungs, addressing the inflammation that is happening in the first place and then using B cell therapy to regenerate the lung tissue may be your best bet for healing.

31 Loka 20231h 46min