298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Jaksot(415)

254 | William Egginton on Kant, Heisenberg, and Borges

254 | William Egginton on Kant, Heisenberg, and Borges

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253 | David Deutsch on Science, Complexity, and Explanation

253 | David Deutsch on Science, Complexity, and Explanation

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AMA | October 2023

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252 | Hannah Ritchie on Keeping Hope for the Planet Alive

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Our planet and its environment are in bad shape, in all sorts of ways. Those of us who want to improve the situation face a dilemma. On the one hand, we have to be forceful and clear-headed about how ...

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251 | Rosemary Braun on Uncovering Patterns in Biological Complexity

251 | Rosemary Braun on Uncovering Patterns in Biological Complexity

Biological organisms are paradigmatic emergent systems. That atoms of which they are made mindlessly obey the local laws of physics; even cells and organs do their individual jobs without explicitly u...

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250 | Brendan Nyhan on Navigating the Information Ecosystem

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18 Syys 202357min

249 | Peter Godfrey-Smith on Sentience and Octopus Minds

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The study of cognition and sentience would be greatly abetted by the discovery of intelligent alien beings, who presumably developed independently of life here on Earth. But we do have more than one d...

11 Syys 20231h 28min

AMA | September 2023

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Welcome to the September 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by P...

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