298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

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248 | Yejin Choi on AI and Common Sense

248 | Yejin Choi on AI and Common Sense

Over the last year, AI large-language models (LLMs) like ChatGPT have demonstrated a remarkable ability to carry on human-like conversations in a variety of different concepts. But the way these LLMs ...

28 Elo 20231h 12min

247 | Samuel Bowles on Economics, Cooperation, and Inequality

247 | Samuel Bowles on Economics, Cooperation, and Inequality

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/08/21/247-samuel-bowles-on-economics-cooperation-and-inequality/ Economics, much like thermodynamics, is a story of collect...

21 Elo 20231h 20min

246 | David Stuart on Time and Science in Maya Civilization

246 | David Stuart on Time and Science in Maya Civilization

You might remember the somewhat bizarre worries that swept through certain circles back in 2012, based on the end of the world being predicted by the Maya calendar. The world didn't end, which is unsu...

14 Elo 20231h 9min

AMA | August 2023

AMA | August 2023

Welcome to the August 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patr...

7 Elo 20233h 38min

245 | Solo: The Crisis in Physics

245 | Solo: The Crisis in Physics

Physics is in crisis, what else is new? That's what we hear in certain corners, anyway, usually pointed at "fundamental" physics of particles and fields. (Condensed matter and biophysics etc. are just...

31 Heinä 20234h 22min

244 | Katie Elliott on Metaphysics, Chance, and Explanation

244 | Katie Elliott on Metaphysics, Chance, and Explanation

Is metaphysics like physics, but cooler? Or is it a relic of an outdated, pre-empirical way of thinking about the world? Closer to the former than the latter. Rather than building specific quantitativ...

24 Heinä 20231h 36min

243 | Joseph Silk on Science on the Moon

243 | Joseph Silk on Science on the Moon

The Earth's atmosphere is good for some things, like providing something to breathe. But it does get in the way of astronomers, who have been successful at launching orbiting telescopes into space. Bu...

17 Heinä 20231h 11min

242 | David Krakauer on Complexity, Agency, and Information

242 | David Krakauer on Complexity, Agency, and Information

Complexity scientists have been able to make an impressive amount of progress despite the fact that there is not universal agreement about what "complexity" actually is. We know it when we see it, per...

10 Heinä 20231h 33min

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