298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

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251 | Rosemary Braun on Uncovering Patterns in Biological Complexity

251 | Rosemary Braun on Uncovering Patterns in Biological Complexity

Biological organisms are paradigmatic emergent systems. That atoms of which they are made mindlessly obey the local laws of physics; even cells and organs do their individual jobs without explicitly u...

25 Syys 20231h 11min

250 | Brendan Nyhan on Navigating the Information Ecosystem

250 | Brendan Nyhan on Navigating the Information Ecosystem

The modern world inundates us with both information and misinformation. What are the forces that conspire to make misinformation so prevalent? Can we combat the flow of misinformation, perhaps by lega...

18 Syys 202357min

249 | Peter Godfrey-Smith on Sentience and Octopus Minds

249 | Peter Godfrey-Smith on Sentience and Octopus Minds

The study of cognition and sentience would be greatly abetted by the discovery of intelligent alien beings, who presumably developed independently of life here on Earth. But we do have more than one d...

11 Syys 20231h 28min

AMA | September 2023

AMA | September 2023

Welcome to the September 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by P...

4 Syys 20234h 3min

248 | Yejin Choi on AI and Common Sense

248 | Yejin Choi on AI and Common Sense

Over the last year, AI large-language models (LLMs) like ChatGPT have demonstrated a remarkable ability to carry on human-like conversations in a variety of different concepts. But the way these LLMs ...

28 Elo 20231h 12min

247 | Samuel Bowles on Economics, Cooperation, and Inequality

247 | Samuel Bowles on Economics, Cooperation, and Inequality

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/08/21/247-samuel-bowles-on-economics-cooperation-and-inequality/ Economics, much like thermodynamics, is a story of collect...

21 Elo 20231h 20min

246 | David Stuart on Time and Science in Maya Civilization

246 | David Stuart on Time and Science in Maya Civilization

You might remember the somewhat bizarre worries that swept through certain circles back in 2012, based on the end of the world being predicted by the Maya calendar. The world didn't end, which is unsu...

14 Elo 20231h 9min

AMA | August 2023

AMA | August 2023

Welcome to the August 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patr...

7 Elo 20233h 38min

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