Benzodiazepine EXPERT Reveals Liver Metabolism Secrets

Benzodiazepine EXPERT Reveals Liver Metabolism Secrets

Discover the fascinating world of benzodiazepines as we break down their metabolism, kinetics, and clinical impact. In this episode, we explore how the liver processes these commonly prescribed medications, highlighting the critical role of the cytochrome P4503A4 system. Learn why some benzodiazepines bypass phase 1 oxidation and how this affects their safety in elderly patients or those with liver disease. We also dive into the science of drug interactions, detailing how inhibitors and inducers of the SIP 3A4 enzyme can significantly alter plasma concentrations of benzodiazepines like diazepam. Plus, find out why tolerance develops, including uncoupling, receptor internalisation, and receptor insensitivity at the GABAA site. Whether you're a clinician or curious learner, this video equips you with essential knowledge on selecting the right benzodiazepine for specific conditions like anxiety, insomnia, or epilepsy. Don’t miss our insights into the dangers of long-term use and the development of tolerance.

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Opioid use disorder and pregnancy

Opioid use disorder and pregnancy

Episode 18 of Cracking Addiction explores the management of opioid use disorder in pregnancy.Most women presenting with opioid dependence are of child-bearing age with chaotic drug use predisposes to amenorrhoea. The initiation of opioid substitution therapy (OST) facilitates stability and reinstatement of regular menstrual cycles and thus OST is a risk factor for unplanned pregnancy. About Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses availablehttps://www.meducate.com.au

1 Joulu 202117min

Drugs of Concern

Drugs of Concern

Episode 17 of Cracking Addiction explores the range of drugs one can become dependent upon or addicted to and how to identify someone at risk of prescription drug aberrancy.About Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses availablehttps://www.meducate.com.au

24 Marras 202121min

How to take an accurate substance use history

How to take an accurate substance use history

How to take an accurate substance use history.Taking an accurate substance use history is of great importance in the management of addiction. There are a number of strategies that one could use but the most important part of history taking is that of demeanour and empathy. The best results and most accurate information are often obtained when one treats one’s patients with human empathy and in a non-judgemental manner. About Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses availablehttps://www.meducate.com.au

17 Marras 202115min

Methadone and it’s social benefits

Methadone and it’s social benefits

Cracking Addiction explores the social and societal benefits of Methadone. Methadone has a number of benefits that extend from not only the person taking it but also society as a whole. Methadone decreases criminality with the overall reduction in convictions and cautions estimated to be at 10% for each six months enrolled in methadone maintenance therapy with patients in continuous treatment receiving the best outcomes.

10 Marras 202115min

Methadone in Opioid Agonist Therapy

Methadone in Opioid Agonist Therapy

Ferghal & Thileepan explore the role of Methadone in opioid agonist therapy.

3 Marras 202113min

Opioid Replacement Therapy Part 1

Opioid Replacement Therapy Part 1

Episode 13 of Cracking Addiction covers opioid replacement therapy (ORT) and the philosophy and evidence behind this highly effective treatment for patients with opioid use disorder.

26 Loka 202119min

Dependence, Addiction and Opioid Use Disorder

Dependence, Addiction and Opioid Use Disorder

In this episode of Cracking Addiction we cover the difference between dependence and addiction, the intricacies of addiction and provide a definition of opioid use disorder

20 Loka 202113min

OPQRST

OPQRST

Cracking Addiction covers the OPQRST framework and how to use this framework to prescribe safely to patients on opioid medications.

13 Loka 202118min

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