127. Guidelines, COVID, Econsults, COVID19, CDC

127. Guidelines, COVID, Econsults, COVID19, CDC

https://covid19treatmentguidelines.nih.gov/
A National Institutes of Health panel has released new guidelines
against use of hydroxychloroquine plus azithromycin outside of clinical trials

https://www.ncbi.nlm.nih.gov/pubmed/32001253
Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis

Epinephrine is the cornerstone of anaphylaxis management but continues to be underutilized



ANTIBODY—

https://jamanetwork.com/journals/jama/fullarticle/2764954



“Yet, according to Theel, several companies are marketing lateral flow assays as rapid point-of-care tests to identify active COVID-19, something the FDA announced it will take action against. “We do not really know how well these assays work at this point,” Theel said in a follow-up email.”


https://www.sccgov.org/sites/covid19/Pages/press-release-04-21-20-early.aspx
They say the Santa Clara Medical Examiner identified two individuals who died at home on February 6, 2020 and February 17, 2020. And the autopsy came with……..positive for SARS-CoV-2.

https://www.cdc.gov/mmwr/index.html
Titled – Assessment of SARS-CoV-2 Infection Prevalence in Homeless Shelters — Four U.S. Cities, March 27–April 15, 2020
They used PCR to test resident and staff members at 19 homeless shelters- almost 1500 people in total and it was impressive that in those locations for which there was already at least two previous COVID19 test found the rate of positive cases was extremely high

— 17% of residents and staff members in Seattle; roughly 35% of those tested in Boston; and 66% of the residents in san Francisco. This tells us what we already know, this disease spreads like wild fire, of those that it spreads not




https://annals.org/aim/fullarticle/2764585/utility-appropriateness-content-electronic-consultations-across-medical-subspecialties-cohort-study
Utility, Appropriateness, and Content of Electronic Consultations Across Medical Subspecialties: A Cohort Study
Objective of this retrospective cohort study was to assess novel metrics of electronic consult appropriateness and utilityTo assess novel metrics of e-consult appropriateness and To assess novel metrics of e-consult appropriateness and To assess novel metrics of e-consult appropriateness and To assess novel metrics of e-consult appropriateness and To assess novel metrics of e-consult appropriateness.
Most consultations were answered within one day and approximately 70% of the consultations that all 4 criteria for appropriateness indicating about 70% of time the patient could be spared a visit to a specialist and have a better conditions managed by the primary care provider with just subtle guidance from the specialistMost consultations were answered within 1 day, with variation across specialties (73.1% for psychiatry to 87.8% for infectious disease). Overall, 70.2% of e-consults met all 4 criteria for appropriateness; the frequency of unmet criteria varied among specialties.









Jaksot(385)

Episode 391: 402. Functional disability after clinically significant extracranial bleeding: a secondary analysis of ASPREE

Episode 391: 402. Functional disability after clinically significant extracranial bleeding: a secondary analysis of ASPREE

https://www.jthjournal.org/article/S1538-7836(25)00109-6/fulltextAntithrombotic agents, like aspirin and anticoagulants, are essential for treating many cardiovascular conditions. However, a common si...

5 Kesä 20257min

Episode 390: 401. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

Episode 390: 401. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

https://jamanetwork.com/journals/jama/article-abstract/2834632SummaryThe article examines the effectiveness and safety of zilebesiran, an RNA interference therapeutic agent, when used in combination w...

4 Kesä 20258min

Episode 389: 400. CRP, Lipoprotein A, LDL for cardiac risk assessment

Episode 389: 400. CRP, Lipoprotein A, LDL for cardiac risk assessment

https://www.nejm.org/doi/full/10.1056/NEJMoa2405182?query=recirc_Semantic  Key Takeaways Extended Predictive Value of Biomarkers: High-sensitivity C-reactive protein (CRP), LDL cholesterol, and lipop...

29 Touko 20259min

Episode 388: 399. Use of albumin-adjusted calcium measurements in clinical practice

Episode 388: 399. Use of albumin-adjusted calcium measurements in clinical practice

Desgagnés N et al. Use of albumin-adjusted calcium measurements in clinical practice. JAMA Netw Open 2025 Jan 21; 8:e2455251. (https://doi.org/10.1001/jamanetworkopen.2024.55251)Overall, total calcium...

27 Touko 20257min

Episode 387: 398. Which is Better, Tirzepatide or Semaglutide?

Episode 387: 398. Which is Better, Tirzepatide or Semaglutide?

https://www.nejm.org/doi/10.1056/NEJMoa2416394At 72 weeks, the mean percentage decrease in weight was significantly greater with tirzepatide than with semaglutide (20% vs. 14%). Gastrointestinal side ...

21 Touko 20258min

Episode 386: 397. What is the new drug for smoking cessation?

Episode 386: 397. What is the new drug for smoking cessation?

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832701In this multisite trial, 800 adults who smoked 10 or more cigarettes daily (mean duration of smoking, ≈35 years) were randomize...

9 Touko 20255min

Episode 385: 396. Vitamin D and Kids (CME)

Episode 385: 396. Vitamin D and Kids (CME)

What does the evidence and the guidelines say about the use and testing of Vitamin D in kids

7 Touko 20258min

Episode 384: 395. How accurate is the BMI?

Episode 384: 395. How accurate is the BMI?

Aryee EK et al. Prevalence of obesity with and without confirmation of excess adiposity among US adults. JAMA 2025 Apr 17; [e-pub]. (https://doi.org/10.1001/jama.2025.2704)The rate of obesity was 39.7...

6 Touko 20255min

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