Episode 171: 171.  Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

Episode 171: 171. Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

SGLT2 inhibitors and GLP1 agonists administered without metformin compared to other glucose‐lowering drugs in patients with type 2 diabetes mellitus to prevent cardiovascular events: A systematic review - Escobar - 2021 - Diabetic Medicine - Wiley Online Library

Yes these fancy new drugs work with and without metformin but that does not mean these drugs should be first line!!


Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA | JAMA Network


Yep even 200,000IU of vit D does nothing except raise your vit d level.

Diet and acne: review of the evidence from 2009 to 2020 - Dall’Oglio - - International Journal of Dermatology - Wiley Online Library


What you eat does mess with your acne, or at least says this large observational trial.


Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials | The BMJ

The muscle aches with statins is a common event that it occurs as frequently with the active drug as it does with placebo

Jaksot(385)

Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment

Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment

https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.13350Xu J et al. Hospital-associated venous thromboembolism prophylaxis use by risk assessment at a large integrated health care net...

28 Kesä 20248min

Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing

Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing

https://www.bmj.com/content/385/bmj-2024-079329Overprescription of antibiotics by primary care clinicians is a major modifiable driver of antibiotic resistance. Evidence suggests that peer-comparison ...

27 Kesä 20247min

Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)

Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)

Kityo C et al. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): Week 48 results from a randomised, multicentre, open-label, non-inferio...

25 Kesä 20245min

Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?

Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?

95% CI does NOT mean there is a 95% chance the true value is in the interval. It means that if you continually resample, 95% of your confidence intervals (which will vary every time you resample), wil...

24 Kesä 20248min

Episode 306: 305. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

Episode 306: 305. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae290/7685305?login=trueChildren aged 1-18 years to prevent rickets and to potentially lower the risk for respiratory tract infection...

21 Kesä 202414min

Episode 305: 304. METHODS MONDAY- What is Power?

Episode 305: 304. METHODS MONDAY- What is Power?

What is the power of a study—what is the power calculation? Often say it is the number of people in a study. Power is the probably to correctly reject the null hypothesis. Said differently power is th...

17 Kesä 202415min

Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes

Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes

Question  What is the strength of association between surrogate markers used as primary end points in clinical trials to support Food and Drug Administration (FDA) approval of drugs treating nononcolo...

14 Kesä 20245min

Episode 303: 302. Effects of statin therapy on diagnoses of new-onset diabetes

Episode 303: 302. Effects of statin therapy on diagnoses of new-onset diabetes

The incidence of new-onset diabetes was basically the same but statistically significantly higher for those individuals on low-to-moderate–intensity statins compared with placebo 1.2 vs 1.3% annually ...

13 Kesä 20246min

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