Episode 215: 215. Enteric coated or uncoated aspirin, which is better or safer?
Questioning Medicine20 Joulu 2023

Episode 215: 215. Enteric coated or uncoated aspirin, which is better or safer?

Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial | Clinical Pharmacy and Pharmacology | JAMA Cardiology | JAMA Network

Enteric coating of aspirin delays the breakdown of the tablet until it is in the higher pH of the duodenum and has been shown to reduce gastric erosion5 but has not been shown to reduce gastrointestinal bleeding. We say take enteric coated but no study has shown that enteric coated formulation is safer then uncoated aspirin

post hoc secondary analysis of 10 678 participants with atherosclerotic cardiovascular disease from the ADAPTABLE randomized clinical trial—a reminder, (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness). In that trial they randomized 15,000 patients with coronary artery disease to take 81 mg or 325 mg of aspirin daily.

Roughly half of the pts using 81mg and half of the pts using 325mg were on enteric coated aspirin and half on regular uncoated aspirin. - Median follow-up was ≈2 years

primary outcomes were death, hospitalization for myocardial infarction, or hospitalization for stroke and the primary safety outcomes was major bleeding -- (hospitalization for a bleeding event with use of a blood product or intracranial hemorrhage).---between enteric-coated aspirin and uncoated aspirin among participants

and the answer was there was no difference so when your patient that needs aspirin for secondary prevention ask you should I take enteric-coated aspirin or uncoated aspirin

You can answer

Sound affect

At this time it appears the best available evidence that there likely is no difference between enteric-coated aspirin and uncoated aspirin just make sure you are taking your aspirin

Jaksot(386)

75. Sun Protection, Prostate and Atrial Fib Screening?

75. Sun Protection, Prostate and Atrial Fib Screening?

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74. Lots of articles and 2 that will change guidelines

74. Lots of articles and 2 that will change guidelines

Joe Namath is famous for guaranteeing victory in Super Bowl III. Mark your calendars for 7/24/2018 where I guarantee that two of the articles in this episode will change guidelines. This episode is fu...

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73. Compressing evidence on bones, colon cancer, pregnancy loss and listen questions

73. Compressing evidence on bones, colon cancer, pregnancy loss and listen questions

So much goodness in one podcast it would be a shame to list it all here. So stop reading and just hit play already.

12 Heinä 201835min

72. Swelling Over ACEI and Seizing On 3 Articles

72. Swelling Over ACEI and Seizing On 3 Articles

In this episode we cover what I think it game time ready about our beloved ACEI and then Joe and I talk about 3 articles that you need to know including the new seizure medication just approved by the...

27 Kesä 201828min

71. Breaking Bones and A1C Levels Should Put You into A.fib

71. Breaking Bones and A1C Levels Should Put You into A.fib

In this 'royal' episode I cover new papers on diabetes type 2, osteoporosis and A.fib. As always you can reach me on twitter @andrewbuelt or email me andrewbuelt@gmail.com

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70. More Articles and a Vegan Study To Make a T-Rex Eat a Salad

70. More Articles and a Vegan Study To Make a T-Rex Eat a Salad

So many article so little time AND in this episode Joe stops in to talk about a study that would make ever T-Rex eat a salad

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69. NBA playoffs w/ Coronary Calcium, VEST, and Dialysis O, MY

69. NBA playoffs w/ Coronary Calcium, VEST, and Dialysis O, MY

It is NBA playoff season and this podcast starts with a fast break into coronary calcium testing, Slams into John Mandrola review https://www.medscape.com/viewarticle/893756 with transition into CKD +...

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68. Anti-biotics Still Have Harm and 2 Guidelines to Know About

68. Anti-biotics Still Have Harm and 2 Guidelines to Know About

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