Episode 253: 253.  EMPA-REG OUTCOME - Type 2 Diabetes and Empagliflozin- How Much Money To Save How Many People?

Episode 253: 253. EMPA-REG OUTCOME - Type 2 Diabetes and Empagliflozin- How Much Money To Save How Many People?

EMPA-REG OUTCOME back in 2015 this was the first SGLT2 trial to set the world on fire with Primary Outcome:

death from cardiovascular causes: NNT 46 per 3.1 yrs (at $600 a month, 1 million dollars per life saved)

nonfatal myocardial infarction: NS∞

nonfatal stroke: NS∞





https://www.nejm.org/doi/full/10.1056/nejmoa1504720

Jaksot(387)

Episode 353: 252. 2.4 Million to Prevent 4 Hospitalizations!

Episode 353: 252. 2.4 Million to Prevent 4 Hospitalizations!

Packer M et al. Tirzepatide for heart failure with preserved ejection fraction and obesity. N Engl J Med 2024 Nov 16; [e-pub].https://doi.org/10.1056/NEJMoa2410027  In the industry-funded SUMMIT trial...

13 Joulu 202411min

Episode 352: 251. Safety of Triptans in Patients Who Have or Are at High Risk for Cardiovascular Disease

Episode 352: 251. Safety of Triptans in Patients Who Have or Are at High Risk for Cardiovascular Disease

Wang Z et al. Safety of triptans in patients who have or are at high risk for cardiovascular disease: A target trial emulation. Mayo Clin Proc 2024 Nov; 99:1722. (https://doi.org/10.1016/j.mayocp.2024...

12 Joulu 20246min

Episode 351: 250. STROKE part 3 CME

Episode 351: 250. STROKE part 3 CME

STROKE part 3 CME

29 Marras 20249min

Episode 350: 249. STROKE - LA closure, alteplase vs tenecteplase, and thrombectomy

Episode 350: 249. STROKE - LA closure, alteplase vs tenecteplase, and thrombectomy

CME FOR FREEE

27 Marras 202417min

Episode 349: 248. Stroke- UIA, CHAD-VASC, HAS-BLED, SPARC, PFO

Episode 349: 248. Stroke- UIA, CHAD-VASC, HAS-BLED, SPARC, PFO

CME --- Stroke- UIA, CHAD-VASC, HAS-BLED, SPARC, PFO

26 Marras 202436min

Episode 348: 247. Early diagnostic paracentesis improves outcomes of hospitalized patients with cirrhosis and ascites

Episode 348: 247. Early diagnostic paracentesis improves outcomes of hospitalized patients with cirrhosis and ascites

Beran A et al. Early diagnostic paracentesis improves outcomes of hospitalized patients with cirrhosis and ascites: A systematic review and meta-analysis. Am J Gastroenterol 2024 Nov; 119:2259. (https...

22 Marras 20246min

Episode 347: 246.  Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk

Episode 347: 246. Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk

Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA Internal Medicine | JAMA Network  In a randomized ...

21 Marras 20248min

Episode 346: 245. Duration of benefit and risk of dual antiplatelet therapy after mild ischemic stroke

Episode 346: 245. Duration of benefit and risk of dual antiplatelet therapy after mild ischemic stroke

And now a secondary analysis of the trial focused on the timing of major ischemic events and the potential tradeoffs of benefits and risks,------ maybe there is magic sauce where the benefit is drasti...

20 Marras 20247min

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