Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL

Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL

The primary cardiovascular end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke in a time-to-first-event analysis.

Improvement in

nonfatal stroke was not statistically significant

death from cardiovascular causes was no significant but

hold on it does appear nonfatal MI was significant and is what really drove the entire composite outcome

All the way down to the discussion to find “An important limitation of this trial is that we included only patients with preexisting cardiovascular disease. The effects of semaglutide on primary prevention of cardiovascular events in persons with overweight or obesity but without previous atherosclerotic disease were not studied. “

And that is because if you want to know the inclusion criteria you have to go to the supplementary data—

WHICH NO ONE DOES

This was sneaky and planned and terrible on the part of Novo Nordisk.




https://www.nejm.org/doi/10.1056/NEJMoa2307563?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Jaksot(386)

Episode 352: 251. Safety of Triptans in Patients Who Have or Are at High Risk for Cardiovascular Disease

Episode 352: 251. Safety of Triptans in Patients Who Have or Are at High Risk for Cardiovascular Disease

Wang Z et al. Safety of triptans in patients who have or are at high risk for cardiovascular disease: A target trial emulation. Mayo Clin Proc 2024 Nov; 99:1722. (https://doi.org/10.1016/j.mayocp.2024...

12 Joulu 20246min

Episode 351: 250. STROKE part 3 CME

Episode 351: 250. STROKE part 3 CME

STROKE part 3 CME

29 Marras 20249min

Episode 350: 249. STROKE - LA closure, alteplase vs tenecteplase, and thrombectomy

Episode 350: 249. STROKE - LA closure, alteplase vs tenecteplase, and thrombectomy

CME FOR FREEE

27 Marras 202417min

Episode 349: 248. Stroke- UIA, CHAD-VASC, HAS-BLED, SPARC, PFO

Episode 349: 248. Stroke- UIA, CHAD-VASC, HAS-BLED, SPARC, PFO

CME --- Stroke- UIA, CHAD-VASC, HAS-BLED, SPARC, PFO

26 Marras 202436min

Episode 348: 247. Early diagnostic paracentesis improves outcomes of hospitalized patients with cirrhosis and ascites

Episode 348: 247. Early diagnostic paracentesis improves outcomes of hospitalized patients with cirrhosis and ascites

Beran A et al. Early diagnostic paracentesis improves outcomes of hospitalized patients with cirrhosis and ascites: A systematic review and meta-analysis. Am J Gastroenterol 2024 Nov; 119:2259. (https...

22 Marras 20246min

Episode 347: 246.  Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk

Episode 347: 246. Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk

Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA Internal Medicine | JAMA Network  In a randomized ...

21 Marras 20248min

Episode 346: 245. Duration of benefit and risk of dual antiplatelet therapy after mild ischemic stroke

Episode 346: 245. Duration of benefit and risk of dual antiplatelet therapy after mild ischemic stroke

And now a secondary analysis of the trial focused on the timing of major ischemic events and the potential tradeoffs of benefits and risks,------ maybe there is magic sauce where the benefit is drasti...

20 Marras 20247min

Episode 345: 244. CORRECTED ACOI question and answer

Episode 345: 244. CORRECTED ACOI question and answer

The full podcast -- not sure why the last one cut off early. Question and answer from ACOI

15 Marras 202416min

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