Episode 272: 271. Cologaurd Has a New Test? How Good is it?

Episode 272: 271. Cologaurd Has a New Test? How Good is it?

The company that developed Cologuard also developed this “next generation” multitarget stool DNA test, and has applied for U.S. FDA approval. The new test appears to have similar sensitivity and higher specificity than its predecessor — which means fewer false positives.


  • Positive predictive value (the proportion of positive tests that were true positives for cancer or advanced neoplasia) was 11%.

  • Negative predictive value (the proportion of negative tests that were true negatives for cancer or advanced neoplasia) was 93%.

  • The stool DNA test was substantially more sensitive than FIT (94% vs. 67% for cancer; 43% vs. 23% for advanced precancerous lesions), but slightly less specific.



https://www.nejm.org/doi/10.1056/NEJMoa2310336

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Episode 432: 439. 6 articles in 2026

Episode 432: 439. 6 articles in 2026

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Episode 431: 438. CME- What To Do AFTER PE Diagnosis

Episode 431: 438. CME- What To Do AFTER PE Diagnosis

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Episode 430: edit fix 437. A Brief Review of the Medical Literature!

Episode 430: edit fix 437. A Brief Review of the Medical Literature!

Xin X, et al. Optimal exercise modalities and dosages for blood pressure reduction in adults with prehypertension and established hypertension: A network meta-analysis and dose–response relationship s...

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Episode 429: 436. postpartum burnout., asundexian, semaglutide and ETOH, neck infection, varenicline

Episode 429: 436. postpartum burnout., asundexian, semaglutide and ETOH, neck infection, varenicline

Jafari K, et al. Risk factors for pediatric deep neck infection revisit after emergency department discharge for pharyngitis or localized neck symptoms. Ann Emerg Med 2026 May; 87:605. DOI: 10.1016/j....

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Episode 428: 435. Evolocumab, Statin and CKD, PCN allergy, MRI vs Rotator Cuff

Episode 428: 435. Evolocumab, Statin and CKD, PCN allergy, MRI vs Rotator Cuff

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Episode 427: 434.  6 Articles From Arb to Patient Perspective to Cervical Cancer Screening

Episode 427: 434. 6 Articles From Arb to Patient Perspective to Cervical Cancer Screening

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Episode 426: 433. Salt, Statins, and Stents

Episode 426: 433. Salt, Statins, and Stents

Donato J, et al. Things We Do For No Reason™: Low salt diets for patients with acute heart failure. J Hosp Med 2026 Feb 4; [e-pub]. DOI: 10.1002/jhm.70278.Some guidelines now recommend "normal sodium ...

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Episode 425: 432.  CME LECTURE-  Under Pressure, Blood Pressure

Episode 425: 432. CME LECTURE- Under Pressure, Blood Pressure

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