Episode 289: 288. An RCT for Time Restricted Eating!

Episode 289: 288. An RCT for Time Restricted Eating!

41 adults (mean age, 59) with obesity (mean weight, 99 kg) and prediabetes or diet-controlled diabetes – everyone got the same diet. Same micro- and macronutrient composition; same calorie amounts

Food was prepared in a study kitchen and consumed onsite or taken home.

Key difference

The intervention group was instructed to eat between 8 a.m. and 6 p.m. and to consume 80% of calories by 1 p.m. The control group was instructed to eat between 8 a.m. and midnight, with 55% of calories after 5 p.m.


Weight loss in the two groups was similar at 12 weeks (about 2.4 kg).

3 months—and no difference—


https://www.acpjournals.org/doi/10.7326/M23-3132

Jaksot(386)

Episode 319: 318. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide

Episode 319: 318. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutidethis paper out in JAMA makes you think this is an issue but likely just too much noise with only 17 patietns a...

17 Heinä 20249min

Episode 318: 317. METHODS MONDAY- What is a Confounder?

Episode 318: 317. METHODS MONDAY- What is a Confounder?

Be careful, most observational data have a large amount of confounders not accounted for and even when accounted for you can never account for all the confounders

15 Heinä 202410min

Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease

Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251. Diagnosis:To establish a PAD diagnosis, the resting ankle–brachial index (ABI) remains the initial test of choice in patients with suggest...

10 Heinä 20245min

Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population

Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population

https://jamanetwork.com/journals/jama/article-abstract/2818624Conclusion--“Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. The addition ...

9 Heinä 20246min

Episode 315: 314. METHODS MONDAY! What Is A C-Score?

Episode 315: 314. METHODS MONDAY! What Is A C-Score?

What are c statisticsC-statistic gives the probability a randomly selected patient who experienced an event (e.g. a disease or condition) had a higher risk score than a patient who had not experienced...

8 Heinä 20247min

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonav...

5 Heinä 20245min

Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due to large-artery occlusion in the anterior circulat...

3 Heinä 20247min

Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception

Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception

https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.047438We studied the risk of IS and ICH in women using LG-IUDs—aka mirana-- compared to women not using hormonal contraceptives.  The commonl...

2 Heinä 20245min

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