Episode 305: 304. METHODS MONDAY- What is Power?

Episode 305: 304. METHODS MONDAY- What is Power?

What is the power of a study—what is the power calculation?

Often say it is the number of people in a study. Power is the probably to correctly reject the null hypothesis. Said differently power is the probability we will correctly get a small pvalue

But a power calculation is slightly more than that it is the number of people required to adequetyly statistically calculate the number of people that would be necessary to reject your null hypothesis of no difference when there actually is a difference.

Lets say we have a blood pressure drug and we want to see if it works

Well if you only enroll a small number of people you might not be able to tell a difference between those in the active and those in the control arm

Remember depending on baseline bp you might only see a 4-5mmg hg improvement in your blood pressure and in almost every trial I have ever seen even those individuals that get the placebo have a 1-2mm hg improvement in their bp so with large confidence intervals that are likely to overlap with just a small number of people being tested you wont find a statistical difference between the two drugs. You will end up accepting the null hypothesis since you will see overlap, this is sad because maybe there is real difference but you didn’t enroll enough people to find that difference.

But lets say you want to enroll 5 million people in your trial

This is great, you will have much smaller confidence intervals and you will be able to see there is a difference and properly reject the null hypothesis and be able to get an answer but you might waist years or decades trying to enroll that many people. This is timely and expensive.

Jaksot(385)

66. Zika, Concussion, Hip Surgery, New Guidelines

66. Zika, Concussion, Hip Surgery, New Guidelines

Is Zika as scary as we really think, or is it scarier?! There is a new test for concussion, right? You might wait a day for a hip surgery but don't wait two! Finally, This podcast is sweet but the new...

21 Maalis 201819min

65. A Poor Prognosis of PE, UTI, Smoking

65. A Poor Prognosis of PE, UTI, Smoking

Andrew covers four articles that give a POOR PHYSICIAN PROGNOSIS for the rates of PE, the push for no-antibiotic-UTI, and smoking.

10 Maalis 201819min

61. Joe Is Back To Discuss Three Articles

61. Joe Is Back To Discuss Three Articles

Guess who is back?! Joe joins me on QM and we talk about three recent trials give our thoughts and opinions while we both sip on a Diet Dr. Pepper. It is a quick 20 minutes of us talking out what we a...

4 Helmi 201821min

60. New Format for Questioning Medicine

60. New Format for Questioning Medicine

Turns out when people say, 'You couldn't pay me enough money to quit smoking!' What they meant was "Can you please give me $750?" Kay-x still isn't great. I give my two cents on the hypertension guide...

1 Helmi 201823min

59. DNR Listening to What You Should Watch

59. DNR Listening to What You Should Watch

How good are you at the DNR conversation? It is a conversation we all need to have with our patients no matter the field or specialty of medicine. However, it's a conversation we all avoid like the pl...

8 Joulu 201713min

58. Who pays when they leave AMA?

58. Who pays when they leave AMA?

Does insurance pay? Does the patient pay? What do you think? What do most Doctors think? Is it possible for me to write this entire description in only question form?

1 Joulu 20178min

57. Triple Therapy for AFIB After PCI, Trick or Treat?

57. Triple Therapy for AFIB After PCI, Trick or Treat?

We need to thin out the blood. Afib then to PCI and boom triple therapy. However, I suspect times are changing. It is Halloween and I do my best to play future fortune teller and predict the future in...

1 Marras 201725min

53. How Much Exercise is Just Right?

53. How Much Exercise is Just Right?

We have all heard of Goldilocks when the bed was too hard, too soft, and then just right. A metaphorical description for the J curve of all things in life. Well exercise is no different. Now let's tak...

21 Huhti 201727min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
psykopodiaa-podcast
tiedenaiset-podcast
voi-hyvin-meditaatiot-2
vakeva-elama-viisaampi-mieli-vahvempi-keho
rss-pitaisko-erota
rss-pt-paahtio
rss-narsisti
puhu-muru
rss-kuumilla-aalloilla
meditaatiot-suomeksi
selviytyjat-tarinoita-elamasta
terapiassa
rss-nautinto
junnut-pelissa
rss-uplevel-by-sonja-hannus
rss-addiktit
rss-mighty-finland-podcast
rss-en-saa-unta
rss-fitissa-podcast