Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Jaksot(385)

Episode 198: 198. A Q&A on low back pain

Episode 198: 198. A Q&A on low back pain

a couple points over the last podcast

19 Heinä 202223min

Episode 197: 197. Low Down on Low Back Pain

Episode 197: 197. Low Down on Low Back Pain

Acute low back pain, chronic low back pain, back pain with sciaticain the end unless red flags hold on imaging for 6weeksNSAIDS for acute low back painexercise and spinal manipulative therapy for chro...

7 Heinä 202236min

Episode 196: 196. Medical Update -- STOP SMOKING!! PICC lines, PRE-Diabetes, Sleep in the Hospital, Ortho Surgery!

Episode 196: 196. Medical Update -- STOP SMOKING!! PICC lines, PRE-Diabetes, Sleep in the Hospital, Ortho Surgery!

196. Medical Update -- PICC lines, PRE-Diabetes, Sleep in the Hospital, Ortho Surgery!

3 Kesä 202223min

Episode 195: 195. Medical Update-- GERD guidelines, IV iron, bariatric surgery, DOAC and the Frail Pmts

Episode 195: 195. Medical Update-- GERD guidelines, IV iron, bariatric surgery, DOAC and the Frail Pmts

European Heart JournalBariatric surgery and cardiovascular disease: a systematic review and meta-analysisEur Heart J 2022 Mar 04;[EPub Ahead of Print], SL van Veldhuisen, TM Gorter, G van Woerden, RA ...

5 Touko 202225min

Episode 194: 194. Heart Failure and Diuretics

Episode 194: 194. Heart Failure and Diuretics

SUMMARY--What diuretic do you usually write for during CHF hospitalizations??   If you said furosemide you are not alone  One in a study in JACC 2013 looked at HF hospitalizations in 2009 and 2010 – I...

27 Huhti 202217min

Episode 193: Medical Update 193- Early afib conversion. iPhone batteries, H. Pylori, Our words have meaning!

Episode 193: Medical Update 193- Early afib conversion. iPhone batteries, H. Pylori, Our words have meaning!

Gibbons RC et al. Ultrasound-versus landmark-guided medium-sized joint arthrocentesis: A randomized clinical trial. Acad Emerg Med 2022 Feb; 29:159. (https://doi.org/10.1111/acem.14396. opens in new t...

7 Huhti 202218min

Episode 192: Medical Update 192-- Risk Calculators, Aspirin vs Clopidogrel, Routine Check up, Kiwi

Episode 192: Medical Update 192-- Risk Calculators, Aspirin vs Clopidogrel, Routine Check up, Kiwi

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00572-9/fulltextOld calculators use old studies and can over exaggerate the calculated effecthttps://pubmed.ncbi.nlm.nih.gov/33970197...

22 Maalis 202219min

Episode 191: Medical Update 191- Afib and coffee, elective ortho and PRP, Antibiotic overuse, low back pain

Episode 191: Medical Update 191- Afib and coffee, elective ortho and PRP, Antibiotic overuse, low back pain

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2782015coffee is ok with atrial fibrillation -- just don't go crazy is probably good advicehttps://jamanetwork.com/journals/jaman...

25 Helmi 202223min

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