Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?
Questioning Medicine18 Heinä 2024

Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?

https://www.nejm.org/doi/full/10.1056/NEJMoa2309002
In this placebo-controlled trial, postexposure prophylaxis with nirmatrelvir–ritonavir for 5 or 10 days did not significantly reduce the risk of symptomatic SARS-CoV-2 infection.


https://www.nejm.org/doi/full/10.1056/NEJMoa2309003

https://www.nejm.org/doi/full/10.1056/NEJMoa2118542


Pfizer has some serious problems! #pfizer

Jaksot(385)

Episode 334: 333. Cell Phone Use While Driving and Financial Gain

Episode 334: 333. Cell Phone Use While Driving and Financial Gain

Feedback and Financial Incentives for Reducing Cell Phone Use While Driving: A Randomized Clinical Trial | Public Health | JAMA Network Open | JAMA Network  Question  Can behavioral interventions decr...

2 Loka 20248min

Episode 333: 331. Noncontrast CT Selected Thrombectomy vs Medical Management

Episode 333: 331. Noncontrast CT Selected Thrombectomy vs Medical Management

Noncontrast CT Selected Thrombectomy vs Medical Management for Late-Window Anterior Large Vessel Occlusion | Neurology Most studies that have shown a benefit from endovascular thrombectomy (EVT) for i...

24 Syys 20246min

Episode 332: 330. Does a Multivitamine a Day Keep The Death Away?

Episode 332: 330. Does a Multivitamine a Day Keep The Death Away?

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820369With as many as 1 in 3 US adults using multivitamin supplements, the question as to whether these supplements reduce mortality They ...

18 Syys 20246min

Episode 331: 329. Should We Give AceI or ARBs to Patients with CKD 4 and 5?

Episode 331: 329. Should We Give AceI or ARBs to Patients with CKD 4 and 5?

https://www.acpjournals.org/doi/10.7326/M23-3236Angiotensin-converting–enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) seldom are initiated among patients with chronic kidney disease (...

17 Syys 20247min

Episode 330: 328. Methods Monday, Composite Endpoints

Episode 330: 328. Methods Monday, Composite Endpoints

Composite outcomes You add multiple outcomes together… this is great because you can increase the event rate.. if you are just looking at death lots of people might now die but if you look at death an...

16 Syys 202411min

Episode 329: 327. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening "SHIELD TESTING"

Episode 329: 327. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening "SHIELD TESTING"

ening, the offer of a blood-based screening test boosted CRC screening by 17.5 percentage points over usual care.That is becauseCRC screening proportions were 17.5 percentage points higher in the bloo...

23 Elo 202412min

Episode 328: 327. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk

Episode 328: 327. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk

https://pubmed.ncbi.nlm.nih.gov/38945140/The primary outcome was a composite of myocardial infarction, revascularisation, hospitalisation for heart failure, stroke, or death from cardiovascular causes...

2 Elo 20247min

Episode 327: 326. Should We Prescribe Inhaled Insulin? INHALE-3 TRIAL

Episode 327: 326. Should We Prescribe Inhaled Insulin? INHALE-3 TRIAL

INHALE-3, a randomized trial, 123patients with type 1 dm that compared the efficacy of an inhaled insulin regimen (Afrezza) plus degludec insulin (Tresiba®) against usual care over 17 weeks The study'...

1 Elo 20247min

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