Episode 342: 341.  Methods Monday! What is the problem with stopping a trial EARLY?

Episode 342: 341. Methods Monday! What is the problem with stopping a trial EARLY?

Stopping Trials Early for Benefit: Insights From Recent Pivotal Trials in Chronic Kidney Disease - ScienceDirect

There are 4 major reasons why trials might be stopped early: 1) unequivocal benefit; 2) unacceptable harm; 3) futility; and 4) administrative reasons (enrollment or funding concerns).

trials stopped early for benefit tend to overestimate benefit, a phenomenon referred to as random-high.

trials that stopped early, especially those with <500 events, fail to provide reliable and valid estimates of treatment effect, often overestimating it by nearly 30%

Trials stopped early for harm or futility are less problematic as such data are not used to promote medications.

Published results were based on accrual of 69%, 75%, 93%, and 87% of planned events in CREDENCE, DAPA-CKD, EMPA-KIDNEY, and FLOW, respectively.

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Episode 435: 442. 7 article review

Episode 435: 442. 7 article review

we unpack whether rivaroxaban followed by aspirin improves thromboprophylaxis after hip and knee arthroplasty, put oral GLP-1 therapy orforglipron head-to-head with dapagliflozin for type 2 diabetes, ...

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Episode 434: 441. Coronary Artery Calcium (CAC) -- Yacky Yack, the details on CAC

Episode 434: 441. Coronary Artery Calcium (CAC) -- Yacky Yack, the details on CAC

Does a Coronary Artery Calcium (CAC) scan still earn its place in modern cardiovascular prevention? This podcast cuts through the headlines to examine the recent research, challenge overconfident conc...

31 Elo 48min

Episode 433: 440. CME Understanding Medical Stats

Episode 433: 440. CME Understanding Medical Stats

OMED lecture on how to understand medical stats

21 Elo 33min

Episode 432: 439. 6 articles in 2026

Episode 432: 439. 6 articles in 2026

CME

24 Heinä 25min

Episode 431: 438. CME- What To Do AFTER PE Diagnosis

Episode 431: 438. CME- What To Do AFTER PE Diagnosis

OMED lecture

21 Heinä 26min

Episode 430: edit fix 437. A Brief Review of the Medical Literature!

Episode 430: edit fix 437. A Brief Review of the Medical Literature!

Xin X, et al. Optimal exercise modalities and dosages for blood pressure reduction in adults with prehypertension and established hypertension: A network meta-analysis and dose–response relationship s...

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Episode 429: 436. postpartum burnout., asundexian, semaglutide and ETOH, neck infection, varenicline

Episode 429: 436. postpartum burnout., asundexian, semaglutide and ETOH, neck infection, varenicline

Jafari K, et al. Risk factors for pediatric deep neck infection revisit after emergency department discharge for pharyngitis or localized neck symptoms. Ann Emerg Med 2026 May; 87:605. DOI: 10.1016/j....

15 Kesä 31min

Episode 428: 435. Evolocumab, Statin and CKD, PCN allergy, MRI vs Rotator Cuff

Episode 428: 435. Evolocumab, Statin and CKD, PCN allergy, MRI vs Rotator Cuff

https://pubmed.ncbi.nlm.nih.gov/41903215/  Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV ...

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