Episode 328: Cognitive Rehabilitation and MS with Dr. Nancy Chiaravalloti

Cognitive dysfunction is a common symptom of multiple sclerosis, affecting more than half of the people living with MS. While cognitive issues like changes in memory, difficulty maintaining attention, slower information processing speed and executive function may not be among the most disabling symptoms of MS, they may be among the most disconcerting symptoms.

Whether it's your short-term memory, the ability to find your way to a familiar destination that you've gone to hundreds of times, or your ability to follow conversations with friends or business colleagues, these are the kinds of real-world situations that can bring someone to a hard stop, recognizing that they're changing in profound ways that aren't outwardly apparent. And that's a scary feeling.

Fortunately, researchers are making real progress in developing ways for people living with MS to improve their cognition. This week, Dr. Nancy Chiaravalloti joins me to talk about what researchers are learning and what types of cognitive rehabilitation are available today.

Dr. Chiaravalloti is the Director of the Center for Neuropsychology and Neuroscience Research and the Center for Traumatic Brain Injury Research at Kessler Foundation. Dr. Chiaravalloti's research is focused on ways to stimulate new learning, memory, and processing speed.

We're also sharing some promising results from a preclinical study of an investigational Epstein-Barr Virus vaccine (And we'll explain why this is so important to the MS community!).

Dr. Nuriel Moghavem will take us through a day in the life of an MS Fellow.

We'll share the disappointing results of the Phase 3 clinical trial for Evobrutinib.

And we'll tell you about super-small biological robots that seem capable of doing some amazing things -- including encouraging the growth of healthy nerve cells to replace damaged nerve cells.

We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: Cognitive Rehabilition :22

Promising news from a preclinical study of an investigational EBV vaccine 2:08

A day in the life of an MS Fellow with Dr. Nuriel Moghavem 4:21

Evobrutinib Phase 3 clinical trial has failed to meet its end points 17:19

Biological robots assemble into a "superbot" and encourage the growth of healthy nerve cells 18:28

Dr. Nancy Chiaravalloti discusses breakthrough treatment for cognitive dysfunction in MS 21:19

Share this episode 31:48

Have you downloaded the free RealTalk MS app? 32:08

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LINKS

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STUDY: Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells
https://onlinelibrary.wiley.com/doi/10.1002/advs.202303575

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RealTalk MS Episode 328
Guests: Dr. Nuriel Moghavem and Dr. Nancy Chiaravalloti

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