E23 – Brain on Fire: Understanding Neuroinflammation’s Role in Addiction
brainSTEM3 Helmi 2025

E23 – Brain on Fire: Understanding Neuroinflammation’s Role in Addiction

In this episode of BrainSTEM, Dr. Hilary Marusak is joined by Dr. Eric Woodcock, a leading expert in neuroinflammation and substance use disorders (SUDs), to explore how inflammation in the brain contributes to addiction.


As research on the neurobiological mechanisms of addiction continues to grow, Dr. Woodcock discusses the role of neuroinflammation in conditions like opioid and nicotine use disorders, and its connection to psychiatric disorders such as depression and PTSD. He also highlights his groundbreaking work on using neuroinflammation as a potential target for new treatments, including novel interventions like neurostimulation.


Whether you’re fascinated by the science of addiction or curious about the future of addiction treatment, this episode offers a deep dive into the role of inflammation in the brain and its potential to change how we approach addiction.


🔗 Topics Covered:

  • Understanding neuroinflammation and its role in addiction

  • The connection between neuroinflammation and psychiatric disorders like depression and PTSD

  • Differentiating central vs. peripheral inflammation

  • Neurostimulation as a novel intervention for addiction

  • The future of neuroinflammation-targeted treatments

🌟 Tune in to hear Dr. Woodcock’s expert perspective on how neuroinflammation could revolutionize addiction treatment and prevention.


🔗 Resources Mentioned in the Episode:

📢 Follow us on Instagram @brainstempodcast to submit your questions for future episodes.

🎧 Available now on Spotify and wherever you get your podcasts!

❤️‍🩹 Help is available 24 hours/day at the National Suicide Prevention Lifeline: 1-800-273-8255.

🧠 BrainSTEM is hosted by neuroscientist ⁠Dr. Hilary Marusak⁠. Production by Amanpreet Bhogal, Manmeet Bhogal, and Gabby Maramag. This podcast is made possible by the generous support of the ⁠Society for Neuroscience⁠ and ⁠Michigan Society for Neuroscience⁠.

🎙️ Subscribe, share, and follow us! Email us with topic or guest suggestions. Visit our website: www.brainSTEMpodcast.com. Our video podcasts are also posted on Youtube: https://www.youtube.com/channel/UC2LTYvOoFc6L7p2kUMaFhCA/videos

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E32 – More Than a Mood: Stories and Science of Bipolar Disorder

E32 – More Than a Mood: Stories and Science of Bipolar Disorder

In this two-part episode of BrainSTEM, Dr. Hilary Marusak explores bipolar disorder from two angles: lived experience and neuroscience. In Part 1, she talks with Dr. Maya Schumer, a neuroscientist dia...

22 Heinä 1h 25min

E31 – When Words Aren't Enough: Poetry, Mental Health, and the Healing Power of Art

E31 – When Words Aren't Enough: Poetry, Mental Health, and the Healing Power of Art

In this episode of BrainSTEM, Dr. Hilary Marusak sits down with Alex Sheehan — spoken word poet, mental health advocate, and member of the One Mind Lived Experience community — for a conversation that...

2 Kesä 44min

E30 – Breaking the Silence: Stories and Science of Depression

E30 – Breaking the Silence: Stories and Science of Depression

In this special two-part episode of BrainSTEM, Dr. Hilary Marusak explores one of the most common — and most misunderstood — mental health conditions: depression. We approach it from two angles: first...

2 Kesä 1h 25min

E29 – Your Brain on the Scroll: Kids, Screens, and the Developing Mind

E29 – Your Brain on the Scroll: Kids, Screens, and the Developing Mind

In this episode of BrainSTEM, Dr. Hilary Marusak and guest co-host Natalie Thurston sit down with neuroscientist Dr. Emma Duerden, a researcher at the forefront of understanding how early life experie...

21 Huhti 37min

E28 – Harnessing Lived Experience: Brandon Staglin’s Mission to Transform Mental Health

E28 – Harnessing Lived Experience: Brandon Staglin’s Mission to Transform Mental Health

In this episode of BrainSTEM, Dr. Hilary Marusak sits down with mental health advocate and innovation leader Brandon Staglin, Co-Founder and Chief Advocacy and Engagement Officer of One Mind. Brandon ...

26 Helmi 45min

E27 – Hooked: Food Addiction, Ultra-Processed Diets, and the Brain

E27 – Hooked: Food Addiction, Ultra-Processed Diets, and the Brain

In this episode of BrainSTEM, Dr. Hilary Marusak and co-producer Gabby Maramag sit down with clinical psychologist and leading food addiction researcher Dr. Ashley Gearhardt to unpack the science behi...

12 Helmi 33min

E26 – Neurodiversity, ADHD, and the Future of the Brain

E26 – Neurodiversity, ADHD, and the Future of the Brain

In this episode of BrainSTEM, Dr. Hilary Marusak sits down with neuroscientist, innovator, and thought leader Dr. Prantik Kundu to explore the evolving science and personal realities of neurodiversity...

20 Marras 202552min

E25 – Science Under Threat: NIH Funding Cuts and the Future of Research

E25 – Science Under Threat: NIH Funding Cuts and the Future of Research

In this special episode of BrainSTEM, Dr. Hilary Marusak is joined by Dr. Alaina Jaster, host of Psychedelic Brain Science, a science advocate, and a postdoctoral research fellow in the THINK lab. The...

14 Helmi 202559min

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