How to Make Your Brain Ageless: Prevent Cognitive Decline & Supercharge Your Mind - with Dale Bredesen | EP 197

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The idea that we can live however we want and then rely on a magic treatment for cognitive issues is unrealistic and dangerous. The reality is that our daily choices profoundly impact our brain’s future, and once cognitive decline begins, there is no clear-cut pharmaceutical solution.

I had the pleasure of speaking with Dr. Dale Bredesen, whose book The Ageless Brain is an incredible resource for protecting brain health. He has pioneered a comprehensive approach to preventing and even reversing cognitive decline. This book offers a powerful blueprint not only for sharpening your mind but also for building resilience against neurodegenerative diseases.

In The Ageless Brain, Dr. Bredesen distills decades of research into actionable steps. He explores key lifestyle factors—nutrition, sleep, exercise, stress management, and supplementation—that influence cognitive performance and long-term brain resilience. What’s exciting is his proactive, personalized approach. Rather than waiting for symptoms to appear, Dr. Bredesen shows us how to build a brain that resists aging from the start.

Today, we’ll unpack some of the most impactful strategies from his book, discuss major breakthroughs in neuroscience, and explore how we can all take charge of our cognitive health. If you’ve ever wondered what it takes to maintain lifelong clarity and vitality, you won’t want to miss this conversation.

Dale Bredesen, MD, is an internationally recognized neurologist specializing in neurodegenerative diseases. He is the Senior Director of Precision Brain Health at Pacific Neuroscience Institute® and the Chief Scientific Officer at Apollo Health.

Guided by his belief that Alzheimer’s is not just preventable but reversible, Dr. Bredesen’s groundbreaking research has helped explain the biological mechanisms behind memory loss. His decades of study have led to new treatment approaches, including the ReCODE Protocol™—also known as the Bredesen Protocol—a strategy designed to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s, dementia, and mild cognitive impairment.

Timestamps:
0:00 Introduction to Guest

2:48 Phase 3 Trial Upcoming

10:11 Alzheimer’s: Different Triggers, Different Outcomes

13:11 Could Brushing Your Teeth Save Your Brain? (Oral Microbiome & Alzheimer’s

18:45 The 3 Major Players in Brain Health

22:24 How to Make Sure You Never Get Dementia

22:33 Blood Markers for Alzheimer’s: What Your Tests Reveal

28:10 Diabetes and Alzheimer’s: The Hidden Connection

34:18 The #1 Contributor to Cognitive Decline: Insulin Resistance

39:54 How to Match Your Brainspan to Your Lifespan

40:31 Top Supplements for Brain Health

43:15 The Power of Nitric Oxide for Your Brain

48:07 Leaky Gut & Cognitive Decline

54:15 Metformin & Brain Longevity

57:31 Why Do More Men Than Women Get Parkinson’s

1:05:24 ADHD & Alzheimer’s: The Fruit Fly Discovery ("Alzflymers")

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Dale Bredesen, M.D., is an expert in neurodegenerative diseases such as Alzheimer’s. He is a graduate of Caltech and received his MD from Duke University Medical Center. His career includes serving as Chief Resident in Neurology at UCSF, working as an NIH Postdoctoral Fellow, and holding faculty positions at UCSF, UCLA, and UC San Diego. He was the director of the Program on Aging at the Burnham Institute and the founding President and CEO of the Buck Institute. His work has led to a new therapeutic approach for treating Alzheimer’s. He is the author of The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.

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