The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld  : 1265

The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?

In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism.

You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory.

So what’s the one upgrade that can actually reset your gut… for good?

What You’ll Learn in This Episode:

• Why your gut—not your brain—is making most of your decisions

• How 93% of probiotics on the market fail before they reach your intestines

• The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO

• What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it)

• The shocking gut–brain–heart axis connection you’ve never heard of

• Why inflammation, brain fog, and mood swings may start with leaky gut

• Which probiotic strains are clinically proven to improve cognition and mood

• What to do if you want to eat gluten again—or survive American wheat

• How a fermented papaya concentrate could replace your acid reflux meds

• Why optimizing your gut could extend your lifespan by 40%


***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***

SPONSORS

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

OMNi-BiOTiC's Instagramhttps://www.instagram.com/fatty15/

OMNi-BiOTiC's Website: https://omnibioticlife.com/

2025 Biohacking Conference: https://biohackingconference.com/2025

Danger Coffee: https://dangercoffee.com

Dave Asprey’s Website: https://daveasprey.com

Dave Asprey’s Linktree: https://linktr.ee/daveasprey

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

Own an Upgrade Labs: https://ownanupgradelabs.com

Upgrade Labs: https://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com


Timestamps:

00:00 – Trailer

03:15 – Intro

05:05 – Probiotics, Prebiotics, and Postbiotics Explained

08:21 – The Importance of Delivery Mechanisms

17:36 – Addressing SIBO and Gut Health Protocols

31:55 – The Impact of GLP-1 Drugs on Gut Health

39:26 – The Role of Gut Bacteria in Hunger and Fasting

40:01 – Painkillers and Gut Health: A Personal Experience

40:51 – The Dangers of Proton Pump Inhibitors

42:00 – The Importance of Stomach Acid

44:55 – Probiotics for Chronic Conditions

48:38 – The Impact of Glyphosate on Gut Health

57:04 – Alcohol and Gut Bacteria

01:02:01 – New Solutions for Acid Reflux

01:07:57 – The Future of Gut Health and Longevity

01:11:33 – Conclusion and Special Offer

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1428)

Wired to Lead the Neobiological Revolution – Jane Metcalfe : 1025

Wired to Lead the Neobiological Revolution – Jane Metcalfe : 1025

IN THIS EPISODE OF THE HUMAN UPGRADE™… the guest is one of the founders of Wired Magazine and someone who has been a continuous source of interest, news and data for decades, Jane Metcalfe. Having basically dissected nerds for her entire life, Jane now runs a fantastic newsletter and news site called NEO.LIFE where she writes about biohacking and the future. If you were to combine someone who really understands society and understands tech (and has read as much science fiction as possible) you would have Jane. Jane’s, focus throughout her, career has been on how technology is transforming our world. But now she is fascinated with how deeply we can see inside the body and how processing the data we collect allows us to discover new cells, understand complex biological systems, and engineer bacteria, viruses, DNA, and ultimately ourselves. Her new platform, NEO.LIFE is for exploring how we Homo sapiens will use these technologies and new understandings to power our own evolution. Watch this episode on YouTube!Get all the links and resources in the show notes.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Get the week’s news and fresh ideas from the neobiological frontier. https://neo.lifeJoin us at the 9th Annual Biohacking Conference: https://biohackingconference.comDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / AmazonSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Helmi 20231h 31min

Dave Asprey Shares All Things “Smarter Not Harder” – Interviewed by Rich Diviney : 1024

Dave Asprey Shares All Things “Smarter Not Harder” – Interviewed by Rich Diviney : 1024

IN THIS EPISODE OF THE HUMAN UPGRADE™... to celebrate the imminent release of the new book, we’re doing something different than what you're used to. Dave is getting interviewed on his own podcast to give you a preview of his book, Smarter Not Harder.In the interviewer's seat is retired Navy SEAL commander, author, expert in leadership and human performance, Rich Diviney. When Rich was a guest on the show previously (check out episode #937), he talked about mindset, optimism, resilience, and stress. This time, the script gets flipped.This interview intends to educate and inform about the new book and install some new capabilities in your operating systems. The goal is that even if you don't read the book, you will still walk away from this interview with a brain that works better.Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want is about helping you to become the best version of yourself by embracing laziness while increasing your energy and optimizing your biology. Rich is the perfect person to dive deeply into how the big ideas in this book work and give you an even greater reason to get the mind and body you want. Dave packed “Smarter Not Harder” with practical, accessible information based on the latest research so you can achieve lasting health in less time. It’s biohacking fully applied. You can pick up a copy of Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want at your favorite place to buy books.Watch this episode on YouTube!Get all the links and resources in the show notes.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Sleep Solutions for High Performance: https://sleepbreakthrough.com/dave, use code DAVE10 to get an extra 10% offDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon9th Annual Biohacking Conference: https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Helmi 202357min

Acknowledge Your Limits and Get Your Brain Back – A 'Smarter Not Harder' Intervention – Cindy Fraley : 1023

Acknowledge Your Limits and Get Your Brain Back – A 'Smarter Not Harder' Intervention – Cindy Fraley : 1023

IN THIS EPISODE OF THE HUMAN UPGRADE™... Dave talks with Cindy Fraley, who has a young daughter, works in upper-level management at a large pharmaceutical company, and is a former physical therapist who overcame RA, MRSA, Hashimoto’s and emotional stress. Cindy says, “Dave’s guidance, the Upgraded Collective, and biohacking have been pivotal in my journey back to the great health, sports, and outdoor activities that I previously had and love.”In fact, in the past year, Cindy has improved her Blood work significantly using EDTA chelation suppositories, sauna, and IV therapy to deal with mold, metals, and coronary calcification. She’s done a deep dive into meditation and forgiveness and has incorporated HeartMath into her day. Cindy is also proudly managing her work stress better so it doesn’t impact her sleep or family interactions. During this intervention and episode, Cindy would like Dave’s help to continue working on stress reduction/management and focus on her brain and neurological fitness. Find all the links and resources in the show notes.Watch this episode on YouTube.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Shield Yourself from EMFs: https://quantumupgrade.io, use code DAVE to get a two-week free trialDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon9th Annual Biohacking Conference: https://biohackingconference.comNote: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Helmi 202331min

How to Become a Durable Super-Dad – A 'Smarter Not Harder' Intervention – Bryan Gardner : 1022

How to Become a Durable Super-Dad – A 'Smarter Not Harder' Intervention – Bryan Gardner : 1022

IN THIS EPISODE OF THE HUMAN UPGRADE™... Dave talks with Bryan Gardner (a self proclaimed “super-dad”) who wants to take his current hacking to the next level. Bryan has questions specifically about his brain & neurology, his fitness, and spirituality. Bryan is an aerospace engineer who built a small hedge fund business more than a decade ago. So he doesn’t sound like someone who would be struggling with productivity, focus and managing his energy.This episode covers many meaningful and helpful topics, including blood flow restriction, high intensity intervals, neuromuscular electrical stimulation, neurofeedback, and a whole lot more. Watch this episode on YouTube!Get all the resources and links in the show notes.------WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Customized Nootropics for Your Own Neurochemistry: https://nootopia.com/dave, use code DAVE10 to get 10% offHumic & fulvic minerals provide critical cellular support. Go to https://www.beamminerals.com and use code DAVE20 to get 20% off.9th Annual Biohacking Conference: https://biohackingconference.com-------Note: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Helmi 202334min

Hacking Your Spirituality - A 'Smarter Not Harder' Intervention - Mandy Pennington : 1021

Hacking Your Spirituality - A 'Smarter Not Harder' Intervention - Mandy Pennington : 1021

IN THIS EPISODE OF THE HUMAN UPGRADE™... Dave talks with Mandy Pennington, a longtime Upgrade Collective member and dedicated hacker who has used biohacking techniques successfully to upgrade her body and mind.Mandy is a sharp and curious person who wants to learn more about how to apply the topics in Smarter Not Harder to her spirituality, quantum energy, spirit guides, and leading a purpose-driven life that feels right for her soul.An important aspect of this episode is focussed on how Mandy can refine her current spirituality practices, and increase her spiritual resilience to align with the next steps on her biohacking journey. Which is something that will likely resonate with you. Watch this episode on YouTube!Note: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / AmazonKnowing Labs: Test Your Own Biology: https://knowinglabs.com/dave, use code dave to save 20% off any test kitCapture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewideSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Helmi 202333min

Is Remaining Curious the Key to Life, Science and Everything? – Gurudev Sri Sri Ravi Shankar : 1020

Is Remaining Curious the Key to Life, Science and Everything? – Gurudev Sri Sri Ravi Shankar : 1020

IN THIS EPISODE OF THE HUMAN UPGRADE™... I am honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles. Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than 50 million followers who do breathwork every single morning. He has worked for 40 years as a global ambassador for peace at the highest levels. I did his breathwork exercises every morning without fail for five years while fixing my mind, body and nervous system, and I have a huge amount of respect for his work in the world. It was a joy to chat with him in person and his childlike curiosity, enthusiasm for teaching, and deep understanding of the world are echoed in every word of this episode. Gurudev is a true visionary, so I am grateful that he set aside time to talk with me so I could share his wisdom with you. Watch this episode on YouTube!WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Sleep Solutions for High Performance: https://sleepbreakthrough.com/dave, use code DAVE10 to get an extra 10% offComfort Options for Hot & Cold Sleepers: https://sleep.me/daveasprey, use code ASPREY for 25% off your purchaseDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / AmazonSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Helmi 202335min

Exploring Human Potential, Sciencing Spirituality, and Getting Intense – Danica Patrick Interviews Dave Asprey : 1019

Exploring Human Potential, Sciencing Spirituality, and Getting Intense – Danica Patrick Interviews Dave Asprey : 1019

IN THIS EPISODE OF THE HUMAN UPGRADE™...I do something different. Over the past 1000+ episodes, I have spent a lot of time talking and learning from my guests, but I have heard over and over that you would like to hear more from me about what I am doing, trying and thinking. Well, that can be awkward to do sitting alone in front of a microphone. A while ago, Danica Patrick interviewed me and it is one of my favorite podcast interviews ever. Danica did a great job of digging into why I do what I do, why I think the way I think, and best of all she allowed me to talk about parts of my life that I have never talked about anywhere else. So, Danica has kindly allowed me to drop that episode from her podcast, Pretty Intense, right here on the Human Upgrade.You are going to learn a lot from the episode. We hit on a lot of pretty next-level stuff - our conversation even allowed me to dig into the concept of old souls (or reincarnation), and how that affects our current life.Danica is a fascinating person and an excellent interviewer. You are going to enjoy this feed drop. Watch this episode on YouTube!WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Kickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planNature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / AmazonSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Helmi 20231h 26min

Upgrade Spotlight: Connecting Ketones, Metabolism & Energy – H.V.M.N. : 1018

Upgrade Spotlight: Connecting Ketones, Metabolism & Energy – H.V.M.N. : 1018

H.V.M.N. sponsored this episode.IN THIS “UPGRADE SPOTLIGHT” EPISODE OF THE HUMAN UPGRADE™…Metabolic biochemist Latt Mansor, Ph.D., joins the show from H.V.M.N. (Health Via Modern Nutrition), where he leads research for the company. He’s an expert in metabolism who consults with elite sport, military, clinical and research organizations. As a key biomarker of metabolic health, ketones are a source of fuel for your brain and body. They’re different from glucose and fat—and more efficient. Learning about the different kinds of ketones and how they work can help you both understand and harness their power. This discussion explains exogenous ketones, BDO-specific ketones BHB and ketone esters. You’ll also find out how to measure your ketones and why it’s important.Ketones have been shown to be anti-inflammatory. Another benefit happens during exercise. The increase in your ketone levels directly increases BDNF (brain-derived nootropic factor). When you raise ketones, you have a more flexible brain.Latt gets into the research behind H.V.M.N.’s development of drinkable ketones to improve performance. Ketone-IQ™ give you advantages like:Mental clarity and cognitive benefitsOxygen efficiencySustained energyPerformance, endurance and recoveryWeight management and improved metabolic healthSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://hvmn.com/DAVE, use code Dave to get 20% off.Watch this episode on YouTube!NEW IN 2023!Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon9th Annual Biohacking Conference: Come join like-minded people for three days of awesome biohacking, learning and connecting! June 22-24, 2023, in Orlando, Florida. https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Helmi 202344min

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