275 - Inside Regeneron’s Groundbreaking Hearing Loss Gene Therapy Treatment Program

275 - Inside Regeneron’s Groundbreaking Hearing Loss Gene Therapy Treatment Program

Gene therapy is rapidly emerging as a transformative approach for treating genetic hearing loss, with Regeneron advancing one of the field’s most promising candidates: DB-OTO. In this conversation, Regeneron's Auditory Global Program Head Dr. Jonathon Whitton provides an in-depth look at the company’s work developing a gene therapy targeting otoferlin-related hearing loss, a rare but significant condition causing congenital deafness in children. Whitton explains the scientific rationale behind targeting the OTOF gene, the challenges of delivering gene therapy to the inner ear, and why this therapy holds particular promise for pediatric patients. He also discusses how Regeneron is designing clinical trials with long-term outcomes in mind, as well as the broader implications for treating other forms of genetic hearing loss. This discussion offers valuable insights into the future of hearing therapeutics and the role large biotech companies may play in making genetic treatments more accessible.


The following Regeneron pages highlight the company’s research on gene therapies for hearing loss and provide information on genetic testing and navigating a hearing loss diagnosis:

  • https://aboutgenetichearingloss.com
  • https://www.regeneron.com/stories/auditory-gene-therapy

Be sure to subscribe to our channel for the latest episodes each week and follow This Week in Hearing on LinkedIn and X (formerly Twitter).- https://twitter.com/WeekinHearing- https://www.linkedin.com/company/this-week-in-hearing- https://hearinghealthmatters.org/thisweek/

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304 - Regenerative Cell Therapy for Hearing Loss: Rincell-1 from Rinri Therapeutics

304 - Regenerative Cell Therapy for Hearing Loss: Rincell-1 from Rinri Therapeutics

Can regenerative medicine move beyond managing symptoms to actually restore natural hearing?Brian Taylor speaks with Simon Chandler, CEO of Rinri Therapeutics, about the company’s pioneering cell ther...

11 Syys 202520min

303 - Regenerative Therapies for Sudden Hearing Loss: AC102 from AudioCure

303 - Regenerative Therapies for Sudden Hearing Loss: AC102 from AudioCure

What if a regenerative therapy could not only halt sudden hearing loss but also help the inner ear repair itself? Dr. Reimar Schlingensiepen, CEO of Berlin-based biotech AudioCure, joins Brian Taylor ...

4 Syys 202525min

302 - Connecting Hearing and Health: Collaboration, Cognition, and the Future of Care

302 - Connecting Hearing and Health: Collaboration, Cognition, and the Future of Care

Madison Levine sits down with Dave Kemp to share her journey from founding a private practice to shaping it into a clinic that bridges hearing care with the wider healthcare system, emphasizing the ro...

2 Syys 202531min

301 - Phonak Virto R Infinio Custom Hearing Aids: Exploring Fit, Features, and First Impressions

301 - Phonak Virto R Infinio Custom Hearing Aids: Exploring Fit, Features, and First Impressions

Phonak has introduced the Virto R Infinio, its first fully rechargeable custom in-the-ear hearing aid. Built on the Infinio platform, Virto R offers a deeply recessed, discreet fit while delivering th...

27 Elo 202523min

300 - Inside the Cochlear Nexa Implant System: Advancing Hearing Outcomes Through Innovation

300 - Inside the Cochlear Nexa Implant System: Advancing Hearing Outcomes Through Innovation

What if a cochlear implant could adapt and improve throughout a patient’s lifetime? Hearing health advocate and author Gael Hannan sits down with Brendan Murray, Vice President of CI Product Portfolio...

25 Elo 202523min

299 - OCT Imaging Reveals New Insights into Meniere’s Disease and Other Inner Ear Disorders

299 - OCT Imaging Reveals New Insights into Meniere’s Disease and Other Inner Ear Disorders

For the first time, optical coherence tomography (OCT) is being used to study the human inner ear directly in patients. In this follow-up conversation, Dr. John Oghalai, Professor and Chair of the Car...

21 Elo 202523min

298 - Exploring ReSound Enzo IA Hearing Aids: Super-Power Performance, Advanced Connectivity, and More

298 - Exploring ReSound Enzo IA Hearing Aids: Super-Power Performance, Advanced Connectivity, and More

ReSound has introduced the Enzo IA, its newest super-power hearing aid built for people with severe-to-profound hearing loss. Smaller and rechargeable, Enzo IA offers up to 28 hours of battery life wh...

19 Elo 202540min

297 - From Recipient to Advocate: Angela Irwin’s Mission to Support Cochlear Implant Users

297 - From Recipient to Advocate: Angela Irwin’s Mission to Support Cochlear Implant Users

What happens when the technology that restores your hearing comes with ongoing costs that insurance often won’t cover? Angela Irwin—bilateral cochlear implant recipient, TEDx speaker, confidence coach...

14 Elo 202523min

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