Communicable E21: FMT for C. difficile infections - does it work?
Communicable23 Helmi 2025

Communicable E21: FMT for C. difficile infections - does it work?

Several publications have described wondrous therapeutic effects of faecal microbiota transplant (FMT) on Clostridioides difficile infection. Yet the recent randomised trial assessing FMT in US veterans was terminated early for futility. In this episode, hosts Angela Huttner and Marc Bonten delve into the history, application, and complexities of FMT with experts Maria Vehreschild (Frankfurt University Hospital, Germany) and Dimitri Drekonja (Minneapolis Veteran Affairs Care System and University of Minnesota, US), who led the US trial. From the regulatory challenges and trial nuances to important new research, this conversation sheds light on a potentially revolutionary yet controversial treatment.

Episode was edited by Kathryn Hostettler and peer-reviewed by Arjana Zerja (Mother Theresa University Hospital Centre, Tirana, Albania).

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Literature

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Communicable E64: Getting micro on macrolides for community-acquired pneumonia

Communicable E64: Getting micro on macrolides for community-acquired pneumonia

In this episode of Communicable, hosts Emily McDonald and Marc Bonten are joined by Sylvain Lother and Valentijn Schweitzer for a discussion on the use of macrolides in community-acquired pneumonia. T...

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Communicable E63: Does oseltamivir harm critically ill patients? The REMAP-CAP results

Communicable E63: Does oseltamivir harm critically ill patients? The REMAP-CAP results

At the Critical Care Reviews meeting in Belfast in June this year, REMAP-CAP investigators presented results suggesting that oseltamivir may be harmful in critically ill patients with influenza, upend...

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Communicable E62: The 'prose' and cons of the POET trial – early oral antibiotic switch for endocarditis

Communicable E62: The 'prose' and cons of the POET trial – early oral antibiotic switch for endocarditis

In this episode of Communicable, Emily McDonald and Josh Davis host Henning Bundgaard and Sami El-Dalati for a discussion on early oral antibiotic switch for endocarditis, focusing on the POET trial, ...

6 Syys 52min

Communicable E61: We will make you love PK/PD, part 3

Communicable E61: We will make you love PK/PD, part 3

In this episode of Communicable, Amy Legg (Brisbane, Australia), Rekha Pai Mangalore (Melbourne, Australia) & Angela Huttner (Geneva, Switzerland) return for the third part of the ‘We will make you lo...

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Communicable E60: Quarterly catch-up (August 2026 edition)

Communicable E60: Quarterly catch-up (August 2026 edition)

In the second edition of 'Quarterly catch-up', CMI Communications editors Emily McDonald and Erin McCreary round-up the biggest news in infectious diseases and review clinical microbiology and infecti...

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Communicable E59: 'Ask me anything' – EUCAST and CLSI leadership explain

Communicable E59: 'Ask me anything' – EUCAST and CLSI leadership explain

In this episode of Communicable, Nav Narayanan and Thomas Tängdén kick off the first 'Ask me anything' episode, inviting EUCAST and CLSI leadership Sören Gatermann, Christian Giske and Amy Mathers to ...

26 Heinä 1h 9min

Communicable E58: Reducing hospital-acquired pneumonia – the HAPPEN trial and how it happened

Communicable E58: Reducing hospital-acquired pneumonia – the HAPPEN trial and how it happened

In this episode of Communicable, Angela Huttner and Josh Davis are joined by Brett Mitchell, Aline Wolfensberger and Lauren Clack to discuss the HAPPEN trial to prevent hospital-acquired pneumonia led...

12 Heinä 54min

Communicable E57: We will make you love PK/PD, part 2

Communicable E57: We will make you love PK/PD, part 2

In this episode of Communicable, Thomas Tängdén and Rekha Pai Mangalore return for part 2 of the ‘We will make you love PK/PD’ series. In this round, they are joined by Iris Minichmayr (Austria) and P...

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