The Science of Drug Discovery: Insights from Artem Evdokimov
632nm18 Marras 2024

The Science of Drug Discovery: Insights from Artem Evdokimov

In this episode, drug discovery scientist Artem Evdokimov discusses the science of pharmaceutical development, from historical breakthroughs to the current landscape. He shares insights on antibiotics resistance, the obesity drug Ozempic, and technical details of drug screening methods like DNA-encoded libraries.

The conversation covers the economics of drug development, the potential of AI, and broader philosophical questions about human health and medicine. Evdokimov emphasizes the importance of avoiding oversimplification in science while highlighting both the triumphs and ongoing challenges in pharmaceutical research.

03:18 Historical Roots of Medicine
05:33 Evolution of Drug Delivery Methods
12:52 Modern Drug Discovery and Challenges
45:39 Understanding the Drug Discovery Process
47:30 Challenges in Gene Therapy
49:26 Complexities of Human Physiology
53:14 The Role of Receptors and Hormones
01:28:12 The Selenium Shortage and Shampoo Dilemma
01:28:54 Challenges in Drug Manufacturing and Distribution
01:34:23 Antibiotic Resistance: A Growing Concern
01:45:18 The Future of Drug Discovery and AI
02:11:01 Exploring AI and Drug Discovery
02:11:41 Outsourcing in Pharma: Pros and Cons
02:13:56 High Throughput Screening and Machine Learning
02:16:37 Challenges and Future of Drug Discovery


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Twitter @ https://x.com/632nmPodcast
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Michael Dubrovsky @ https://x.com/MikeDubrovsky
Misha Shalaginov @ https://x.com/MYShalaginov
Xinghui Yin @ https://x.com/XinghuiYin

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Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269
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WEBSITE:
https://www.632nm.com

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Synthetic Biology: George Church on Genome Sequencing and De-Extinction

Synthetic Biology: George Church on Genome Sequencing and De-Extinction

The great George Church takes us through the revolutionary journey of DNA sequencing from his early groundbreaking work to the latest advancements. He discusses the evolution of sequencing methods, including molecular multiplexing, and their implications for understanding and combating aging. We talk about the rise of biotech startups, potential future directions in genome sequencing, the role of precise gene therapies, the ongoing integration of nanotechnology and biology, the potential of biological engineering in accelerating evolution, transhumanism, the Human Genome Project, and the importance of intellectual property in biotechnology. The episode concludes with reflections on future technologies, the importance of academia in fostering innovation, and the need for scalable developments in biotech.02:38 Innovations in DNA Sequencing03:15 The Evolution of Sequencing Methods07:41 Longevity and Aging Reversal12:12 Biotech Startups and Commercial Endeavors17:38 Future Directions in Genome Sequencing28:10 Humanity's Role and Transhumanism37:23 Exploring the Connectome and Neural Networks38:29 The Mystery of Life: From Atoms to Living Systems39:35 Accelerating Evolution and Biological Engineering41:37 Merging Nanotechnology and Biology45:00 The Future of Biotech and Young Innovators47:16 The Human Genome Project: Successes and Shortcomings01:01:10 Intellectual Property in Biotechnology01:06:30 Future Technologies and Final ThoughtsFOLLOW US ON SOCIAL:Twitter @ https://x.com/632nmPodcastSubstack: https://632nmpodcast.substack.com/Michael Dubrovsky @ https://x.com/MikeDubrovskyMisha Shalaginov @ https://x.com/MYShalaginovXinghui Yin @ https://x.com/XinghuiYinSUBSCRIBE:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWEBSITE:https://www.632nm.com

22 Loka 20241h 10min

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