40 - Phage
Bedside Rounds12 Marras 2018

40 - Phage

Bacteriophages -- viruses that target and kill bacteria -- were one of the most promising medical treatments of the early 20th century, and were used to treat all sorts of infections, from cholera to staph, and everything in between. But by the 1950s, they had all but died out in the West. This episode tells the story of the humble phage, from its discovery in the waters of the Ganges, love trysts ending in a KGB execution, and to a resurgence of this once forgotten therapy in the 21st century as an answer to antibiotic resistance.

Sources:

  • Abedon ST, Bacteriophage prehistory: Is or is not Hankin, 1896, a phage reference? Bacteriophage. 2011 May-Jun; 1(3): 174–178.
  • Blair JE and Williams REO, "Phage Typing of Staphylococci," Bull Org mond. Ste, 1961, 24, 771-784.
  • Davis BM and Waldor MK, Filamentous phages linked to virulence of Vibrio cholera, Current Opinion in Microbiology 2003, 6:35-42.
  • d'Herelle F, "Bacteriophage as a treatment in acute medical and surgical infections," Bull N Y Acad Med. 1931 May; 7(5): 329–348.
  • d'Herelle F. Sur un microbe invisible antagoniste des baccilles dysenteriques. CR Acad Sci Paris 1917,163,173-5.
  • Eaton MD, Bayne-Jones S. Bacteriophage Therapy. JAMA 1934; 103:1769-76; 1847-53; 1934-9.
  • Fruciano DE and Bourne S, Phage as an antimicrobial agent: d'Herelle's heretical theories and their role in the decline of phage prophylaxis in the West, Can J Infect Dis Med Microbiol. 2007 Jan; 18(1): 19–26
  • Hankin EH. L'action bactericide des eaux de la Jumna at du Gange sur le vibrion du cholere. Ann Int Pasteur (Paris) 1896,10,511-23.
  • Himmelweit F. Combined action of penicillin and bacteriophage on Staphylococci. Lancet. 1945;ii:104.
  • Hicks DJ et al, "Developments in rabies vaccines," Clin Exp Immunol. 2012 Sep; 169(3): 199–204.
  • Kingwell K, Bacteriophage therapies re-enter clinical trials, Nature, Vol 14, Aug 2015, 515.
  • Jensen MA et al, Modeling the role of bacteriophage in the control of cholera outbreaks, Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12): 4652–4657.
  • Hargreaves KR and Clokie MRJ, Clostridium difficile phages: still difficult? Front Microbiol. 2014 Apr 28;5:184.
  • La Fee S and Buschman H, Novel Phage Therapy Saves Patient with Multidrug-Resistant Bacterial Infection. Retrieved from: https://health.ucsd.edu/news/releases/Pages/2017-04-25-novel-phage-therapy-saves-patient-with-multidrug-resistant-bacterial-infection.aspx
  • Leitner L et al, Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial. BMC Urol. 2017 Sep 26;17(1):90.
  • Pearce J, Louis Pasteur and Rabies: a brief note, Journal of Neurology, Neurosurgery & Psychiatry 2002;73:82.
  • Schooley et al, Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant acinetobacter baumannii infection. Antimicrobial Agent and Chemotherapy, 14 Aug 2017.
  • Strathdee S, How Sewage Saved My Husband's Life from a Superbug, TEDxNashville, retrieved from: https://www.youtube.com/watch?v=AbAZU8FqzX4.
  • Summers WC, Bacteriophage Therapy, Annual Review of Microbiology, Vol. 55:437-451 (Volume publication date October 2001)
  • Summers WC, The strange history of phage therapy. Bacteriophage. 2012 Apr 1; 2(2): 130–133.
  • Taylor M.W. (2014) Introduction: A Short History of Virology. In: Viruses and Man: A History of Interactions. Springer, Cham
  • Thiel, K. (2004). Old dogma, new tricks—21st Century phage therapy. Nature Biotechnology, 22(1), 31–36.
  • Twort FW, An investigation on the nature of Ultra-Microscopic Viruses, The Lancet, Jan 10th, 1914. 101.
  • Wittebole X et al, A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014 Jan 1; 5(1): 226–235.
  • Ujmajuridze et al, Adapted Bacteriophages for Treating Urinary Tract Infections. Front Microbiol. 2018; 9: 1832.
  • Ventola CL, "The Antibiotic Resistance Crisis: Part 1: Causes and Threats," P T. 2015 Apr; 40(4): 277–283.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(86)

22 - The Assassination

22 - The Assassination

A mortally wounded American president and the quest to find his assassin's bullet unexpectedly opened up a potentially new era of medical diagnostics in the late nineteenth century. In this episode, l...

24 Huhti 201717min

21 - Renegades

21 - Renegades

Does medicine have a place for renegades who play by their own rules? Producer Cam Steele brings us a story about medical mavericks drinking toxic cocktails of their own creation, threading rubber tub...

25 Maalis 201723min

20 - Buried Alive

20 - Buried Alive

The nineteenth century was struck by a collective panic about being buried alive, leading to a bevy of new laws, regulations, and inventions like the safety coffin.  In this episode, we explore how me...

21 Helmi 201724min

19 - Of Madness and Moons

19 - Of Madness and Moons

Can the moon make you crazy? The superstition is rampant in medicine, but the idea that a full moon awakens psychiatric pathologies traces back thousands of years. In Episode 19 of Bedside Rounds, pro...

19 Tammi 201721min

18 - Dr. Livingstone, I presume?

18 - Dr. Livingstone, I presume?

By the time that David Livingstone died on the banks of Lake Bangweulu, his name was already legend -- first, as a great explorer, becoming the first European to lay eyes on Victoria Falls and Lake Ma...

30 Joulu 201621min

17 - The Iceman

17 - The Iceman

In 1991, two hikers near the Austrian-Italian border discovered the 5,000 year-old mummified body of Otzi the Iceman buried in a glacier. What have we learned about medicine from the Iceman? From a fu...

25 Marras 201615min

16 - Phineas

16 - Phineas

Everyone knows the story of Phineas Gage, the young man who had a tamping iron shot through his brain in a freak accident and miraculously survived, only to have extreme personality changes. But the t...

26 Loka 201617min

15 - Innumeracy

15 - Innumeracy

Understanding statistics has never been more important for the practice of medicine. Unfortunately, innumeracy plagues the medical field. Listen to Episode 15 of Bedside Rounds to learn more, and mayb...

4 Syys 201614min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
vakeva-elama-viisaampi-mieli-vahvempi-keho
tiedenaiset-podcast
psykopodiaa-podcast
rss-pitaisko-erota
voi-hyvin-meditaatiot-2
rss-kuumilla-aalloilla
meditaatiot-suomeksi
rss-uplevel-by-sonja-hannus
puhu-muru
rss-nautinto
junnut-pelissa
rss-laadukasta-ensihoitoa
rss-narsisti
rss-vapaudu-voimaasi
katilon-kahvitunti
terapiassa
fitnessvastaanotto
rss-pt-paahtio
traumapodi