58 - The Original (Antigenic) Sin
Bedside Rounds26 Loka 2020

58 - The Original (Antigenic) Sin

The COVID-19 pandemic laid bare the racial health disparities in the United States, with markedly increased mortality especially among Blacks and Native Americans. In this episode, Tony Breu and I discuss the conception of race, racism, and the social determinants of health through three historic plagues in the United States -- from yellow fever in New Orleans, to poliomyelitis, and finally the early days of HIV/AIDS -- and what lessons we can draw for COVID-19. Along the way, we'll discuss the unique social capital afforded by acclimation, immunity passports, the concept of the "original antigenic sin," and constitutionalism and eugenics. This presentation was performed live at the annual meeting of the Massachusetts American College of Physicians, and is only lightly edited.

SOURCES:

  • Monath TP, Yellow fever: an update. Lancet Infect Dis. 2001 Aug;1(1):11-20. doi: 10.1016/S1473-3099(01)00016-0.
  • Kallas EG, D'Elia Zanella LGFAB, Moreira CHV, Buccheri R, Diniz GBF, Castiñeiras ACP, Costa PR, Dias JZC, Marmorato MP, Song ATW, Maestri A, Borges IC, Joelsons D, Cerqueira NB, Santiago E Souza NC, Morales Claro I, Sabino EC, Levi JE, Avelino-Silva VI, Ho YL. Predictors of mortality in patients with yellow fever: an observational cohort study. Lancet Infect Dis. 2019 Jul;19(7):750-758. doi: 10.1016/S1473-3099(19)30125-2. Epub 2019 May 16. Erratum in: Lancet Infect Dis. 2019 Nov;19(11):e370. PMID: 31104909.
  • Blake LE, Garcia-Blanco MA. Human genetic variation and yellow fever mortality during 19th century U.S. epidemics. mBio. 2014 Jun 3;5(3):e01253-14. doi: 10.1128/mBio.01253-14. PMID: 24895309; PMCID: PMC4049105.
  • Jelili Ojodu, MPH1, Mary M. Hulihan, MPH2, Shammara N. Pope, MPH2, Althea M. Grant, PhD2,, MMWR, Incidence of Sickle Cell Trait — United States, 2010.
  • IthaMaps, Haemoglobin Epidemiology. https://www.ithanet.eu/db/ithamaps?country=GR
  • Serjeant GR, The natural history of sickle cell disease. Cold Spring Harb Perspect Med. 2013 Oct; 3(10): a011783.
  • Hamosh A, FitzSimmons SC, Macek M Jr, Knowles MR, Rosenstein BJ, Cutting GR. Comparison of the clinical manifestations of cystic fibrosis in black and white patients. J Pediatr. 1998 Feb;132(2):255-9. doi: 10.1016/s0022-3476(98)70441-x. PMID: 9506637.
  • Gershman KD et al, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country. CDC.
  • Kofler N and Baylis F, Ten reasons why immunity passports are a bad idea. Nature 21 May 2020.
  • NASEM, National Academies Release Framework for Equitable Allocation of a COVID-19 Vaccine for Adoption by HHS, State, Tribal, Local, and Territorial Authorities.
  • Schmidt H et al, Covid-19: how to prioritize worse-off populations in allocating safe and effective vaccines.BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m3795 (Published 05 October 2020).
  • Siegal FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirschman SZ, Cunningham-Rundles C, Adelsberg BR, et al. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med. 1981 Dec 10;305(24):1439-44. doi: 10.1056/NEJM198112103052403. PMID: 6272110.
  • Lushniak BD, Surgeon General's Perspectives. Public Health Rep. 2014 Mar-Apr; 129(2): 112–114.
  • Booske BC et al, "Different Perspectives For Assigning Weights to Determinants of Health," University of Wisconsin Population Health Institute.
  • Marc LG et al,HIV among Haitian-born persons in the United States, 1985–2007, AIDS. Author manuscript; available in PMC 2011 Aug 24.
  • Rogers N, Race and the Politics of Polio: Warm Springs, Tuskegee, and the March of Dimes. Am J Public Health. 2007 May; 97(5): 784–795.
  • Curran JW and Jaffe HW, AIDS: the Early Years and CDC's Response. MMWR.
  • Olivarius Kathryn, Immunity, Capital, and Power in Antebellum New Orleans. The American Historical Review, Volume 124, Issue 2, April 2019, Pages 425–455,

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(86)

The Adventure of the Speckled Band by Sir Arthur Conan Doyle

The Adventure of the Speckled Band by Sir Arthur Conan Doyle

Sir Arthur Conan Doyle considered The Adventure of the Speckled Band to be his best Holmes story, and Adam does too. Meant to be a companion to Episode 35 (Sherlock), this is the story in its entirety...

4 Kesä 201851min

34 - The Physical

34 - The Physical

The physical exam has become a ritual of the modern doctor's appointment, with pokes, prods, and strange tools. How did this become a normal thing to do? In this episode, I'll discuss how the physical...

4 Touko 201833min

33 - Alexis and William

33 - Alexis and William

Alexis St. Martin and William Beaumont have one of the strangest relationships in the history of medicine -- a young French-Canadian fur trapper with a hole in his stomach from an errant shotgun blast...

4 Huhti 201831min

32 - The Humors

32 - The Humors

The Four Humors are probably the longest-lasting idea in the history of medicine, even though they've been more or less completely abandoned for the past century or so. In this episode, we'll explore ...

3 Maalis 201832min

31 - Malariotherapy

31 - Malariotherapy

Malariotherapy -- infecting comatose syphilis patients with malaria to cure them of the disease -- was once the cutting edge of medicine, and earned its inventor Julius Wagner-Jauregg the Nobel Prize ...

2 Helmi 201838min

30 - The Orphan Vaccine

30 - The Orphan Vaccine

Two hundred years ago, a few doctors, a matron, and 22 orphans set sail in a gutsy attempt to spread the new invention of vaccination across three continents in the world's first attempt to eliminate ...

5 Tammi 201825min

29 - Curse of the Ninth

29 - Curse of the Ninth

Did the famous composer Gustav Mahler work his fatal heart murmur into his final ninth symphony? To try and answer this question, I'm joined by Dr. Kevin Nordstrom of the Great Composers Podcast. We'l...

13 Joulu 201726min

28 - Smallpox Blankets

28 - Smallpox Blankets

The story of smallpox blankets offered as gifts to indigenous peoples as a weapon of war is ubiquitous -- but is it based in truth? And did our increased medical understanding of smallpox lead to its ...

9 Marras 201732min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
vakeva-elama-viisaampi-mieli-vahvempi-keho
psykopodiaa-podcast
tiedenaiset-podcast
rss-pitaisko-erota
voi-hyvin-meditaatiot-2
rss-kuumilla-aalloilla
meditaatiot-suomeksi
rss-nautinto
rss-uplevel-by-sonja-hannus
rss-pt-paahtio
terapiassa
rss-vapaudu-voimaasi
katilon-kahvitunti
puhu-muru
junnut-pelissa
traumapodi
fitnessvastaanotto
rss-laadukasta-ensihoitoa
rss-narsisti