APP Roundtable: Future Directions in CHB Research
GHAPPcast10 Heinä 2025

APP Roundtable: Future Directions in CHB Research

In this episode, physician assistant Alison Moe, P-C, and Carolyn Legaspi, NP, explore the future of hepatitis B research and management, including promising therapeutic developments and critical care gaps. Together, they discuss the complexity of chronic hepatitis B infection, the global burden of disease, and why achieving a functional cure remains elusive despite current antiviral therapies. The conversation highlights cutting-edge research on therapeutic vaccines—including the first entering Phase 1 clinical trials in early 2024—and the potential role of immune modulators in achieving long-term viral suppression. Carolyn and Alison also address major research challenges, such as targeting HBV’s persistent cccDNA, reaching underserved populations, and the low global treatment rate (only 3% as of 2022). They emphasize the urgent need for improved access to testing, earlier intervention in children and adolescents, and strategies to close gaps in care, especially in high-risk communities. For healthcare providers, this discussion offers valuable insight into the evolving hepatitis B treatment landscape and the ongoing efforts to reduce liver-related morbidity and mortality worldwide.

#HepatitisB #HBVCure #LiverHealth #HepatologyEducation #TherapeuticVaccines #FunctionalCure #ChronicHBV #LiverDiseaseAwareness #Gastroenterology #AdvancedPracticeProviders #GHAPP #MedicalResearch #HBVElimination #ViralHepatitis

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GHAPPcast: Recognizing and Managing Overt Hepatic Encephalopathy

GHAPPcast: Recognizing and Managing Overt Hepatic Encephalopathy

Thank you to Salix for their support on this podcast episode. In this GHAPP podcast, host Christina Hanson, FNP, welcomes Janet Gripshover, DNP, FNP-BC, MBA, for a practical discussion on recognizing ...

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FAQ: Counseling Patients on Overt Hepatic Encephalopathy

FAQ: Counseling Patients on Overt Hepatic Encephalopathy

Thank you to Salix for their support on this FAQ video module.In this FAQ video module, Natalie Oliver, PA-C, discusses how healthcare professionals can counsel patients and caregivers about overt hep...

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FAQ: Identifying & Diagnosing Overt Hepatic Encephalopathy

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Thank you to Salix for their support on this FAQ video module. In this FAQ video module, Samantha Ramirez, NP-C, discusses how healthcare professionals can identify and diagnose overt hepatic encephal...

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Subgroup Analysis: Differences in Maintenance Dosing For UC and CD

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Thank you to Johnson & Johnson for their support on this podcast episode. In this GHAPP podcast, Amy Stewart, NP, of Capital Digestive Care, introduces a practical inflammatory bowel disease discussio...

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Medication Review: Efficacy & Safety of Risankizumab in Patients with Moderate to Severely Active UC

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Thank you to AbbVie for their support of this Medication Review Video Module.In this medication review, Melissa Ferrari, PA, and Jennifer Hamilton, MSPAS, PA-C, provide a comprehensive overview of the...

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Med Review: SEQUENCE Trial: Risankizumab vs Ustekinumab in Anti-TNF-Refractory Crohn’s Disease

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Thank you to AbbVie for their support on this Medication Review Video Module. In this medication review, Sharon Dudley-Brown, CRNP, PhD from Johns Hopkins University and Angelina Collins, MSN, ANP-BC,...

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FAQ: QUASAR Long Term Extension Interim Analysis

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Thank you to Johnson & Johnson for their support on this FAQ Video Module. In this educational video, Jamie Brogan, APRN, from Northwestern Medicine, reviews the latest QUASAR long-term extension data...

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Medication Review: Guselkumab IV vs SC Formulation

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Thank you to Johnson & Johnson for their support on this Medication Review Video Module. In this quick educational video, Angelina Collins, NP, from the University of California San Diego Inflammatory...

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