#09 - David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?

#09 - David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?

In this episode, my good friend David Sabatini delves into his extensive work with the mechanistic target of rapamycin—better known as mTOR—and rapamycin. The compound rapamycin is the only known pharmacological agent to extend lifespan all the way from yeast to mammals—across a billion years of evolution. David, a professor of biology and a member of the Whitehead Institute at MIT, shares his remarkable journey and discovery of mTOR in mammalian cells and its central role in nutrient sensing and longevity. Fasting, rapamycin, mTOR, autophagy, gedankenexperiments: having this conversation with David is like being the proverbial kid in the world's greatest candy store.

We discuss:

  • mTOR and David's student years [4:30];
  • Rapamycin and the discovery of mTOR [8:15];
  • The connection between rapamycin, mTOR, and longevity [30:30];
  • mTOR as the cell's general contractor [34:45];
  • The effect of glucose, insulin, and amino acids on mTORC1 [42:50];
  • Methionine sensing and restriction [49:45];
  • An intermittent approach to rapamycin [54:30];
  • Rapamycin's effects on cancer, cardiovascular disease, and neurodegeneration [57:00];
  • Gedankenexperiment: couch potatoes on rapamycin vs perfectly behaved humans [1:03:15];
  • David's dream experiment with no resource constraints [1:07:00]; and
  • More.

Learn more at www.PeterAttiaMD.com

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#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

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#358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6

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#357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

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#356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more

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