#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

In this episode, Nav Chandel, a professor of medicine and cell and molecular biology at Northwestern University, discusses the role of mitochondria and metabolism in health and disease. Nav also provides insights into the mitochondria as signaling organelles, antioxidants, and metformin's multifaceted effects on human health, among many topics related to well-being.

We discuss:

  • What got Nav interested in mitochondria [5:00];
  • Reactive oxygen species (ROS) [16:00];
  • Antioxidants: helpful or harmful? [20:00];
  • Mitochondria as signaling organelles [22:00];
  • Hydrogen peroxide (H2O2) [25:00];
  • Mitochondrial DNA [28:00];
  • Mitochondria and aging [45:00];
  • Metformin [52:45];
  • Metformin and the gut microbiome [54:00];
  • Metformin as complex I inhibitor and the importance of the NADH/NAD ratio [1:01:00];
  • Anticancer benefits of metformin [1:07:45];
  • Mitochondrial function is necessary for tumorigenesis [1:15:00];
  • Are somatic mutations the result of mitochondrial dysfunction? [1:31:30];
  • Vitamins and antioxidants [1:37:00];
  • Targeting inflammation in disease [1:43:00];
  • NAD precursors [1:45:45];
  • MitoQ [1:52:00];
  • Metabolite toxicity [1:56:30];
  • Cortisol and healthy aging [2:02:00];
  • Nav turns the tables and asks Peter how he deals with the "So what should I eat?" question during social encounters [2:09:00]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(434)

#363 ‒ A new frontier in neurosurgery: restoring brain function with brain-computer interfaces, advancing glioblastoma care, and new hope for devastating brain diseases | Edward Chang, M.D.

#363 ‒ A new frontier in neurosurgery: restoring brain function with brain-computer interfaces, advancing glioblastoma care, and new hope for devastating brain diseases | Edward Chang, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Edward Chang is a neurosurgeon, scientist, and a pioneering leader...

8 Syys 20251h 53min

Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D. (#287 rebroadcast)

Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D. (#287 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Stuart McGill is a distinguished professor emeritus at the Univers...

1 Syys 20252h 31min

#361 - AMA #74: Sugar and sugar substitutes: weight control, metabolic effects, and health trade-offs

#361 - AMA #74: Sugar and sugar substitutes: weight control, metabolic effects, and health trade-offs

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explains how to eva...

18 Elo 202515min

#360 ‒ How to change your habits: why they form and how to build or break them | Charles Duhigg, M.B.A

#360 ‒ How to change your habits: why they form and how to build or break them | Charles Duhigg, M.B.A

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Charles Duhigg is a Pulitzer Prize-winning journalist and best-sel...

11 Elo 20252h 13min

#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Eric Verdin is a physician-scientist and the CEO of the Buck Insti...

4 Elo 20252h 11min

#358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6

#358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes ...

28 Heinä 202512min

#357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

#357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, a...

21 Heinä 20251h 56min

#356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more

#356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter addresses frequentl...

14 Heinä 202517min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
voi-hyvin-meditaatiot-2
vakeva-elama-viisaampi-mieli-vahvempi-keho
tiedenaiset-podcast
psykopodiaa-podcast
rss-pitaisko-erota
puhu-muru
terapiassa
rss-uplevel-by-sonja-hannus
junnut-pelissa
rss-narsisti
rss-kuumilla-aalloilla
katilon-kahvitunti
selviytyjat-tarinoita-elamasta
rss-rakas-mielenterveyteni
rss-duodecim-lehti
meditaatiot-suomeksi
rss-ehjaksi
rss-vapaudu-voimaasi
rss-ayurglow-harmoninen-elama