#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism.

We discuss:

  • Rudy's background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15];
  • Finding the first evidence of leptin by studying obese mice [23:30];
  • Zucker rats, and the push/pull theories of obesity [34:45];
  • A breakthrough in obesity research, and closing in on leptin [45:45];
  • Understanding leptin in humans [1:03:30];
  • What Prader–Willi syndrome teaches us about body weight regulation [1:09:45];
  • Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter's self-experiments [1:18:00];
  • How is appetite being regulated? [1:29:45];
  • Are there epigenetic consequences of being obese? [1:37:00];
  • What makes low-carb diets so effective at obesity reduction? [1:46:15];
  • What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15];
  • Rudy's dream study of the FTO gene [1:57:15];
  • What the hell does insulin resistance actually mean? [2:08:30]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(433)

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tanuj Nakra and Suzan Obagi, two leading experts in aesthetic medi...

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#354 – What the dying can teach us about living well: lessons on life and reflections on mortality | BJ Miller, M.D. and Bridget Sumser, L.C.S.W.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter BJ Miller, a hospice and palliative care physician, and Bridget Su...

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#353 - AMA #72: Fasting: benefits for body composition and disease prevention, potential risks, and Peter's updated practical framework

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter revisits the topic ...

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#352 ‒ Female fertility: optimizing reproductive health, diagnosing and treating infertility and PCOS, and understanding the IVF process | Paula Amato, M.D.

#352 ‒ Female fertility: optimizing reproductive health, diagnosing and treating infertility and PCOS, and understanding the IVF process | Paula Amato, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter This is part two of a two-part mini-series on fertility and reprod...

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#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter This is part one of a two-part mini-series on fertility and reprod...

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#350 ‒ Injury prevention, recovery, and performance optimization for every decade | Kyler Brown, D.C.

#350 ‒ Injury prevention, recovery, and performance optimization for every decade | Kyler Brown, D.C.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Kyler Brown is a sports rehab chiropractor who specializes in inju...

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#349 - AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity

#349 - AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into the...

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#348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.

#348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Rachel Rubin is a board-certified urologist and one of the nation'...

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