#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?
The Peter Attia Drive28 Tammi 2019

#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?

In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer's disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer's treatment and prevention.

We discuss:

  • Background and interest in the brain [5:15];
  • The unique nature of the human brain [9:15];
  • Why we've made so little progress in Alzheimer's research [23:00];
  • The amyloid beta hypothesis [28:30];
  • Hypometabolism in the brain leading to cognitive decline [39:30];
  • Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
  • The vascular hypothesis of Alzheimer's disease [54:00];
  • The relationship between mitochondria, cytochrome c oxidase, and Alzheimer's disease [1:08:00];
  • Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
  • Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
  • Methylene blue for treating and preventing neurodegeneration [1:38:15];
  • Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
  • Near infrared light as a targeted treatment for cognitive decline [2:05:30];
  • The ketogenic diet as a treatment and preventative measure [2:13:15];
  • Exciting future research coming from Francisco [2:23:00];
  • Methylene blue for traumatic brain injuries [2:25:15]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

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#34 - Sam Harris, Ph.D.: The transformative power of mindfulness

#34 - Sam Harris, Ph.D.: The transformative power of mindfulness

In this episode, Sam Harris, neuroscientist, author, and host of the Waking Up Podcast, walks us through the profound, yet practical, ways that meditation can transform our lives. Additionally, he hel...

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#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also get...

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#32 - Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process

#32 - Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process

In this episode, Siddhartha Mukherjee, oncologist, researcher, and author of the Pulitzer Prize-winning book "The Emperor of All Maladies: A Biography of Cancer," discusses his writing process, his th...

10 Joulu 20181h 5min

#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

In this episode, Nav Chandel, a professor of medicine and cell and molecular biology at Northwestern University, discusses the role of mitochondria and metabolism in health and disease. Nav also provi...

3 Joulu 20182h 22min

#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to ...

26 Marras 20182h 48min

#29 - Apolo Anton Ohno: 8-time Olympic medalist – extreme training, discipline, pursuing perfection, and responding to adversity

#29 - Apolo Anton Ohno: 8-time Olympic medalist – extreme training, discipline, pursuing perfection, and responding to adversity

In this episode, 8-time Olympic medalist, Apolo Ohno, discusses the lessons he's learned from his remarkable career in speed skating and the extreme physical and mental training — and determination — ...

19 Marras 20183h 38min

#28 - Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life

#28 - Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life

In this episode, Mark and Chris Bell discuss their love of powerlifting, their unbelievable personal records, and what prompted the making of their now iconic film, Bigger, Stronger, Faster. They also...

12 Marras 20182h 11min

#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provi...

5 Marras 20181h 41min

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