#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?
The Peter Attia Drive28 Tammi 2019

#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?

In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer's disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer's treatment and prevention.

We discuss:

  • Background and interest in the brain [5:15];
  • The unique nature of the human brain [9:15];
  • Why we've made so little progress in Alzheimer's research [23:00];
  • The amyloid beta hypothesis [28:30];
  • Hypometabolism in the brain leading to cognitive decline [39:30];
  • Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
  • The vascular hypothesis of Alzheimer's disease [54:00];
  • The relationship between mitochondria, cytochrome c oxidase, and Alzheimer's disease [1:08:00];
  • Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
  • Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
  • Methylene blue for treating and preventing neurodegeneration [1:38:15];
  • Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
  • Near infrared light as a targeted treatment for cognitive decline [2:05:30];
  • The ketogenic diet as a treatment and preventative measure [2:13:15];
  • Exciting future research coming from Francisco [2:23:00];
  • Methylene blue for traumatic brain injuries [2:25:15]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

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#25 - Scott Harrison: transformation, finding meaning, and taking on the global water crisis

#25 - Scott Harrison: transformation, finding meaning, and taking on the global water crisis

We discuss: How Scott and Peter met [3:45]; Scott's tragic family story that shaped his life and altered his trajectory [8:00]; High school years, rebellion, and music [30:30]; Life as a club promote...

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#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more

#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject o...

19 Loka 20181h 29min

#23 - Tom Dayspring, M.D., FACP, FNLA – Part IV of V: Statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brain

#23 - Tom Dayspring, M.D., FACP, FNLA – Part IV of V: Statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brain

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject o...

18 Loka 20182h

#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins

#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject o...

17 Loka 20181h 4min

#21 - Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation

#21 - Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject o...

16 Loka 20181h 26min

#20 - Thomas Dayspring, M.D., FACP, FNLA – Part I of V: an introduction to lipidology

#20 - Thomas Dayspring, M.D., FACP, FNLA – Part I of V: an introduction to lipidology

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject o...

15 Loka 20181h 14min

#19 - Dave Feldman: stress testing the lipid energy model

#19 - Dave Feldman: stress testing the lipid energy model

In this episode, Dave Feldman, discusses his journey from software engineer to n=1 experimenter, his experience with low-carbohydrate diets, and his hypothesis that cholesterol levels are influenced b...

8 Loka 20183h 10min

#18 - Richard Isaacson, M.D.: Alzheimer's prevention

#18 - Richard Isaacson, M.D.: Alzheimer's prevention

In this episode, Richard Isaacson, a neurologist and director of the Alzheimer's Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian, discusses strategies for staving off Alzheimer's ...

1 Loka 20182h 24min

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