#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?

#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?

In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer's disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer's treatment and prevention.

We discuss:

  • Background and interest in the brain [5:15];
  • The unique nature of the human brain [9:15];
  • Why we've made so little progress in Alzheimer's research [23:00];
  • The amyloid beta hypothesis [28:30];
  • Hypometabolism in the brain leading to cognitive decline [39:30];
  • Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
  • The vascular hypothesis of Alzheimer's disease [54:00];
  • The relationship between mitochondria, cytochrome c oxidase, and Alzheimer's disease [1:08:00];
  • Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
  • Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
  • Methylene blue for treating and preventing neurodegeneration [1:38:15];
  • Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
  • Near infrared light as a targeted treatment for cognitive decline [2:05:30];
  • The ketogenic diet as a treatment and preventative measure [2:13:15];
  • Exciting future research coming from Francisco [2:23:00];
  • Methylene blue for traumatic brain injuries [2:25:15]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(433)

#347 – Peter's takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes ...

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#346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Susan Desmond-Hellmann is a physician and scientist whose remarkab...

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#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sean Mackey is a professor of pain medicine at Stanford University...

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#344 - AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into nic...

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#343 – The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sanjay Mehta is a radiation oncologist with over 25 years of exper...

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#342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center

#342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter joins a unique convers...

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#341 - Overcoming insomnia: improving sleep hygiene and treating disordered sleep with cognitive behavioral therapy for insomnia | Ashley Mason, Ph.D.

#341 - Overcoming insomnia: improving sleep hygiene and treating disordered sleep with cognitive behavioral therapy for insomnia | Ashley Mason, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Ashley Mason is a clinical psychologist and an associate professor...

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#340 - AMA #69: Scrutinizing supplements: creatine, fish oil, vitamin D, and more—a framework for understanding effectiveness, quality, and individual need

#340 - AMA #69: Scrutinizing supplements: creatine, fish oil, vitamin D, and more—a framework for understanding effectiveness, quality, and individual need

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explores the comple...

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