#112 - Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
The Peter Attia Drive1 Kesä 2020

#112 - Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

Ned David is the co-founder of Unity Biotechnology, a company developing senolytic medicines—molecules that target and destroy senescent cells in the human body. In this episode, Ned explains the science of cellular senescence and how it impacts the aging process. Ned discusses how senolytics may delay, prevent, treat, or even reverse age-related diseases, including cancer, cardiovascular disease, and neurodegenerative disease. As a serial entrepreneur, Ned also provides advice on how to transform a simple idea into the creation of a company.

We discuss:

  • Defining longevity and the principles of aging [2:50];
  • The control knobs of aging and how we can turn them [15:10];
  • Role of cellular senescence in aging and cancer [27:00];
  • History of senescence in scientific study [40:30];
  • The cellular senescence paradox [46:00];
  • Developing medicines that target cellular senescence [52:15];
  • Ned's lessons on risk analysis in business [1:05:15];
  • The search for a molecule that could eliminate senescent cells [1:15:15];
  • Senescent cell elimination example in osteoarthritic knees [1:30:30];
  • Extending lifespan by removing senescent cells [1:45:00];
  • Senolytic molecule example in macular degeneration reversal [1:52:30];
  • The future of senescent cell targeting [1:58:30];
  • The role of cellular senescence and metabolic syndrome [2:01:30];
  • The role of cellular senescence and brain health [2:03:30]
  • What prepared Ned to start Unity Biotechnology [2:05:45];
  • Advice for someone deciding between business and academics [2:08:50]; and
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/neddavid

Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(433)

#376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more

#376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter tackles a wide-rang...

15 Joulu 202522min

#375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.

#375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Dom D'Agostino is a neuroscientist and professor at the forefront ...

8 Joulu 20252h 8min

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Carole Hooven is a human evolutionary biologist whose research cen...

1 Joulu 20252h 5min

The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)

The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Walter Green is a remarkable philanthropist, mentor, author of Thi...

24 Marras 20251h 31min

#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.

#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Antonio Bianco is a world-renowned physician-scientist and expert ...

17 Marras 20252h 20min

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter breaks down the sci...

10 Marras 202524min

#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.

#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sally Greenwald is an OB-GYN who specializes in women's sexual hea...

3 Marras 20251h 52min

Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)

Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter provides a comprehensive introducti...

27 Loka 20251h 25min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
tiedenaiset-podcast
psykopodiaa-podcast
voi-hyvin-meditaatiot-2
rss-pitaisko-erota
vakeva-elama-viisaampi-mieli-vahvempi-keho
rss-pt-paahtio
rss-kuumilla-aalloilla
rss-narsisti
meditaatiot-suomeksi
puhu-muru
selviytyjat-tarinoita-elamasta
terapiassa
junnut-pelissa
rss-nautinto
rss-en-saa-unta
fitnesskulmapodcast
rss-uplevel-by-sonja-hannus
rss-duodecim-lehti
rss-mighty-finland-podcast