#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia

#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia

Amanda Grant Smith is a geriatric psychiatrist with decades of experience treating patients with dementia and Alzheimer's disease. In this episode, Amanda shares how she developed a passion for geriatric psychiatry as a means to support dementia patients. She explains how to recognize, define, and diagnose dementia—a process that still remains somewhat elusive. They also talk about the significance of ApoE genotype and compare the various forms of dementia including differentiating between Alzheimer's disease and Lewy body dementia. They discuss the current landscape of clinical trials, the drug pipeline, and talk about a very promising monoclonal antibody directed at amyloid beta that has the potential to be a disease-modifying drug. They conclude with a discussion about how to define "healthy aging" and reflect on how understanding dementia can shape one's life philosophy.

We discuss:

  • How Amanda developed a passion for geriatric psychiatry [3:15];
  • Defining and diagnosing dementia and Alzheimer's disease [13:30];
  • Medical tests for dementia and their relationship to clinical symptoms [22:45];
  • The pathology of dementia, and the role of the tau and beta-amyloid protein in Alzheimer's disease [33:15];
  • The significance of ApoE genotype, and differentiating Alzheimer's disease from Lewy body dementia [43:15];
  • The evolution of Alzheimer's disease prevention, care, and medications over the last 20 years [52:45];
  • Psychiatric support for dementia patients (and caregivers) with depression and anxiety [1:02:45];
  • Drug pipeline, clinical trials, and major challenges to overcome [1:13:45];
  • Redefining Alzheimer's disease and designing effective trials [1:23:00];
  • The promise of monoclonal antibody treatments for Alzheimer's disease [1:34:15];
  • How we should measure outcomes in dementia trials and define "healthy aging" [1:42:30];
  • How understanding dementia can reshape our life philosophy [1:53:45]; and
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/AmandaSmith

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#17 - Mike Trevino: life-lessons from ultra-endurance, mindset, hard work, and removing limitations

#17 - Mike Trevino: life-lessons from ultra-endurance, mindset, hard work, and removing limitations

In this episode, ultra-endurance athlete and entrepreneur, Mike Trevino, discusses the lessons he's learned from his remarkable athletic feats, and the training required to reach them. Not only is Mik...

24 Syys 20181h 56min

#16 - Formula 1 (with Paul Conti): the best drivers, Ayrton Senna, and the cautionary tales of driven individuals

#16 - Formula 1 (with Paul Conti): the best drivers, Ayrton Senna, and the cautionary tales of driven individuals

In this bonus episode, Peter and med school colleague (and brilliant psychiatrist) Paul Conti reminisce on their favorite moments in Formula 1 history, their deep admiration for the late Ayrton Senna,...

20 Syys 20181h 3min

#15 - Paul Conti, M.D.: trauma, suicide, community, and self-compassion

#15 - Paul Conti, M.D.: trauma, suicide, community, and self-compassion

In this episode, psychiatrist Paul Conti, M.D. discusses the impact of untreated trauma, the rising rate of suicide, and the influence of modern society on mental health, to name a few important topic...

17 Syys 20182h 9min

#14 - Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system

#14 - Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system

In this episode, Rob Lustig — a researcher, an expert in fructose metabolism, and a former pediatric endocrinologist — discusses what's wrong with the current food environment, and what we can do to r...

10 Syys 20181h 23min

#13 - Brett Kotlus, M.D.: How to look younger while you live longer

#13 - Brett Kotlus, M.D.: How to look younger while you live longer

This episode explores the question of how we can maintain a naturally youthful look as we get older. Brett — a New York City oculofacial plastic surgeon who specializes in both non-surgical and surgic...

3 Syys 20181h 48min

#12 - Corey McCarthy: Overcoming trauma, dealing with shame, finding meaning, changing the self-narrative, redemption, and the importance of gratitude

#12 - Corey McCarthy: Overcoming trauma, dealing with shame, finding meaning, changing the self-narrative, redemption, and the importance of gratitude

Corey and Peter met when they visited North Kern State Prison in California together as volunteers for Defy Ventures. Peter was moved by Corey's remarkable story, who is a former inmate himself, and r...

27 Elo 20182h 27min

#11 - AMA #2: the Nothingburger — results from Peter's week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting

#11 - AMA #2: the Nothingburger — results from Peter's week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting

Consider this episode a cross between an ask me anything (AMA) and a show-and-tell. Peter discusses his fasting experiment in great detail and answers questions from listeners and readers. We discuss:...

23 Elo 20181h 50min

#10 - Matt Kaeberlein, Ph.D.: rapamycin and dogs — man's best friends? — living longer, healthier lives and turning back the clock on aging, and age-related diseases

#10 - Matt Kaeberlein, Ph.D.: rapamycin and dogs — man's best friends? — living longer, healthier lives and turning back the clock on aging, and age-related diseases

Matt is someone who is deeply interested in understanding the biology of aging. Why do we age? What happens to us as we age? What are the things we can do to slow the aging process? How can we delay o...

20 Elo 20181h 32min

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