#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia
The Peter Attia Drive7 Kesä 2021

#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia

Amanda Grant Smith is a geriatric psychiatrist with decades of experience treating patients with dementia and Alzheimer's disease. In this episode, Amanda shares how she developed a passion for geriatric psychiatry as a means to support dementia patients. She explains how to recognize, define, and diagnose dementia—a process that still remains somewhat elusive. They also talk about the significance of ApoE genotype and compare the various forms of dementia including differentiating between Alzheimer's disease and Lewy body dementia. They discuss the current landscape of clinical trials, the drug pipeline, and talk about a very promising monoclonal antibody directed at amyloid beta that has the potential to be a disease-modifying drug. They conclude with a discussion about how to define "healthy aging" and reflect on how understanding dementia can shape one's life philosophy.

We discuss:

  • How Amanda developed a passion for geriatric psychiatry [3:15];
  • Defining and diagnosing dementia and Alzheimer's disease [13:30];
  • Medical tests for dementia and their relationship to clinical symptoms [22:45];
  • The pathology of dementia, and the role of the tau and beta-amyloid protein in Alzheimer's disease [33:15];
  • The significance of ApoE genotype, and differentiating Alzheimer's disease from Lewy body dementia [43:15];
  • The evolution of Alzheimer's disease prevention, care, and medications over the last 20 years [52:45];
  • Psychiatric support for dementia patients (and caregivers) with depression and anxiety [1:02:45];
  • Drug pipeline, clinical trials, and major challenges to overcome [1:13:45];
  • Redefining Alzheimer's disease and designing effective trials [1:23:00];
  • The promise of monoclonal antibody treatments for Alzheimer's disease [1:34:15];
  • How we should measure outcomes in dementia trials and define "healthy aging" [1:42:30];
  • How understanding dementia can reshape our life philosophy [1:53:45]; and
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/AmandaSmith

Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(433)

#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)

#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Olav Aleksander Bu is an internationally renowned sports scientist...

13 Tammi 20252h 16min

#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.

#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Trenna Sutcliffe is a developmental behavioral pediatrician and th...

6 Tammi 20251h 57min

Building & Changing Habits | James Clear (#183 rebroadcast)

Building & Changing Habits | James Clear (#183 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter James Clear is the author of the New York Times bestseller Atomic ...

30 Joulu 20242h 19min

#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter tackles a wide range o...

16 Joulu 202427min

#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a "best" diet, complexities of nutrition science, and practical steps for building a sustainable diet

#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a "best" diet, complexities of nutrition science, and practical steps for building a sustainable diet

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into one...

9 Joulu 202416min

#327 - Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D.

#327 - Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Dr. Saum Sutaria is the Chairman and CEO of Tenet Healthcare and a...

2 Joulu 20242h 32min

Optimizing life for maximum fulfillment | Bill Perkins (#237 rebroadcast)

Optimizing life for maximum fulfillment | Bill Perkins (#237 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Bill Perkins is one of the world's most successful hedge fund mana...

25 Marras 20241h 43min

#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging

#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives into the worl...

18 Marras 202415min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
psykopodiaa-podcast
tiedenaiset-podcast
voi-hyvin-meditaatiot-2
vakeva-elama-viisaampi-mieli-vahvempi-keho
rss-pitaisko-erota
rss-pt-paahtio
rss-narsisti
puhu-muru
rss-kuumilla-aalloilla
meditaatiot-suomeksi
selviytyjat-tarinoita-elamasta
terapiassa
rss-nautinto
junnut-pelissa
rss-uplevel-by-sonja-hannus
rss-addiktit
rss-mighty-finland-podcast
rss-en-saa-unta
rss-fitissa-podcast