Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Today we're talking to Stephan Guyenet who has a degree in biochemistry and a PhD in neuroscience. He's spent over 12 years in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. He wrote a great book called The Hungry Brain, speaks at conferences, is a Senior Fellow at GiveWell and scientific reviewer for the Examine.com Research Digest.

He is definitely not a low carb person which is why I had him on. He has a lot of great ideas and is a great mind in the space of nutrition. It was very interesting to hear him talk about all the great benefits he did see when he ate a low carb diet 11 years ago. Make sure to listen until the end when he talks about this.

He has some problems with certain people and aspects of the low carb community and is going on Joe Rogan's podcast soon to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic

We had some disagreement on the recommended daily allowance of nutrients - he thinks what's recommended is all you need and getting more than that is pointless. I think this is wrong. I think he's basing it on studies of worthless, non-bioavailable vitamin C pills that in excess do nothing. So in that - I agree. I don't think there's any benefit to popping a bunch of these and think we're going to cure a cold. I do know that our ancestors got estimates of 10-20 times the amount of nutrients we get today, so there's a lot more to this discussion that we didn't have time to get into.

We also disagreed on fiber which led to some carnivore talk. He got some things wrong about the member of the Grateful Dead who was a carnivore. He said he died at a young age of a heart attack. I looked into it and it turns out he was carnivore for 48 years and was in excellent health and died in a car accident at 72.

He also says we don't have longterm studies on the safety of low carb diets at the end. This isn't exactly true and furthermore, we have hundreds of thousands of years of human populations living on low carb diets to prove its safety and efficacy. He additionally mentions the low carb community makes crazy claims that aren't based on science. I'm not sure what he's referring to. Not everything can be measured anyway. If tens of thousands of people report to their doctor they aren't hungry anymore, their energy is stable, their brain is working better, they aren't addicted to sugar, they finally have control of their food intake, etc. then this is some great clinical observations and patient anecdotes that add up to a lot.

I think everyone has their own ideas about things and collects info to support their opinion. It's only natural, and I'm sure I'm doing it to, even though I'm trying not to. Everyone has to be in their camp and collect data and narratives to support their theories. He seemed to do this as you'll see throughout the episode.

I agreed with a lot of his points though, especially that humans didn't evolve to eat based on tracking macros and calories and using an excel spreadsheet to figure out what to eat. He's doing great work and looking at this from a different angle which is important. A lot of interesting stuff here so let's get to it. But first I gotta mention the Food Lies film which is in the last stretch of crowdfunding on Indiegogo. We really need your help to finish it. We have a bunch of cool perks like the Eat Meat T-shirt, the movie poster, bonus features, and more. Find it through FoodLies.org or by clicking through this link in the show notes. I really appreciate it - and now here's Stephan Guyenet.

http://indiegogo.com/projects/food-lies-post

Show Notes

  • I'm obsessed with why we get fat and what to do about it and you've been researching this for a long time
  • Why the brain is the most important place to focus on
  • The brain regulates how much we eat, our food choices, and our exercise
  • There's also non conscious processes the brain regulates that influence caloric expenditure, etc.
  • We also study the human genome to find how that plays a role in body fatness
  • When it comes to body weight, the genes that relate the most are in the brain
  • Nobody wants to overeat, but we end up doing it anyway
  • We need to look at our past to understand why we are wired to seek excess calories
  • Animals and hunter gatherers we've studied follow the Optimum Foraging Theory when they acquire food. It's all about the calories per the amount of effort
  • Because we were eating whole foods from nature, if we got enough calories, we by default we're getting all the vitamins and minerals needed
  • They didn't have white flour, sugar, or refined oils
  • We only have receptors for fat, sugar, salt, and glutamate
  • Apparently those are the nutrients that natural selection cared about most to create reward systems for
  • The Hadza people went mainly for meat, tubers, and honey and didn't go for leafy greens
  • The brain is motivated to pursue calorie containing foods, not vitamins and minerals
  • Combining bliss points make certain foods almost irresistible
  • You need to control your food environment
  • Not only don't have it sitting out so you can see certain foods, don't even have them in the house
  • How do genetics play a role? We know it's way more to do with the type of foods eaten
  • About 70% of people in countries like the US are genetically susceptible to become obese when eating the bad diet that exists there. The remaining percent just aren't as susceptible and can get away with it
  • Energy balance while always be a fact, but there's a lot more to it
  • Eat less, move more may work for some people, but it's not how we evolved. It's not a natural way to regulate body weight
  • You can set up a food environment to allow your body to naturally eat the right amount
  • You'd have to be hungry all the time to continue eating processed foods and try to lose weight
  • His definition and thoughts on nutrient density
  • Questioning the necessity of fiber
  • His views on the carnivore diet - he thinks a big factor is becoming lean and it certainly does that
  • He questions if there's long term chronic disease problems that we don't know about
  • Inuit seek some plant matter
  • Sound engineer from the Grateful Dead who was carnivore for 48 years - Stephan said he died of a heart attack at a young age. Turns out he was super healthy and died of a car accident at 72.
  • His book https://justmeat.co/docs/the-bear.pdf
  • They call him "Bear" https://dangerousminds.net/comments/uncle_johns_ham_the_grateful_deads_all-meat_diet
  • Wikipedia on him: https://en.wikipedia.org/wiki/Owsley_Stanley
  • Stephan agrees with what I always say about going to either end of the extreme with super low carb or super low fat you have great benefits
  • He's going on Joe Rogan's podcast to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic
  • What happened with Gary Taubes and Dr. Peter Attia's non profit venture NuSI - the Nutritional Science Initiative?
  • What Stephan got wrong in his blog posts
  • Why he thinks Gary Taubes is wrong and what is the evidence
  • He doesn't like the fact that Gary is calling out scientists
  • Exercise and weight loss
  • The model of obesity he subscribes to is that it's all regulated by the brain
  • Homeostatic regulation - hypothalamus controls body fatness like a thermostat
  • The hormone leptin sends feedback to your brain regarding body fat levels
  • Personal fat threshold, how someone can be skinny on the outside but fat on the inside, people can be obese but metabolically healthy, and insulin as a dam holding back fat in the cells
  • He doesn't think that eating an insulin lowering diet like low carb allows you to lose weight because of the lowered insulin
  • He thinks low carb diets and low fat diets work merely because you're taking away the extreme motivation to overeat the foods, AKA hyperplatability
  • Potato hack
  • Metabolic flexibility
  • He thinks being metabolically inflexible is more a sign of insulin resistance than anything
  • He eats about 50% carb, 18% protein, 32% fat
  • He ate a low carb diet after reading Taubes' book Good Calories, Bad Calories 11 years ago
  • He said it was about the same but one benefit was that he wasn't tied to meal times. Eating high carb he definitely knew when it was time to eat. Easier to fast
  • He was easily doing 24 hour fasts. Now on high carb it's way harder and he experiences brain fog
  • Why are low carb diets so maligned in the mainstream media and medical system?
  • What are his solutions for fixing the nation's health problems?
  • His book The Hungry Brain http://www.stephanguyenet.com/thehungrybrain/
  • His website http://www.stephanguyenet.com
  • His Twitter https://twitter.com/whsource

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

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Theme music by https://kylewardmusic.com/

Jaksot(233)

Part 161 - Dr. Frederic Leroy Unravels 100 years of the Anti-Meat Agenda

Part 161 - Dr. Frederic Leroy Unravels 100 years of the Anti-Meat Agenda

Specializing in the science and application of animal foods in society and nutrition, Dr. Frederic Leroy is a food scientist, technologist and professor at the University of Brussels. With a dense background in peer-reviewed journals, academic boards, and nonprofits, Dr. Leroy currently is an advocate for a deeper, more nuanced discussion of the importance of animal products, an understanding our our historic relationships with them, and the current war against them in western cultures. Frederic's Twitter Page Watch on YouTube: https://youtu.be/lKGeRAB-K3E Dr. Leroy's slides: https://drive.google.com/file/d/1z7l1vmwCWPnHbyS4BVP-1dx6Jo46dP_a/view?usp=sharing GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [4:10] - Brian and Frederic discuss how the overall health of a society relates to diet and nutrition and how modern fake food plays into them [12:15] - How fake meat corporations are trying to make animal agriculture industry disappear [15:30] - Our connection to butchering, modern animal butchering and how they play into our separation to our ancient ways of living [26:50] - Diving into sensationalism in DailyMail articles since 2000 around Meat [32:50]- Why nuance and context always matters when speaking about foods and specifically meat [35:50] - Do we need meat? Is it fundamental to health? [47:20] - How meat, animal foods, and our relationships to animals provided security for hunter-gatherer communities interactions with animals is changing: slaughtering, butchering, consumption [1:108:30] - The hierarchy of our modern society and the agendas to form mobs, embrace authority, and subvert power [1:22:00] - How our view of death has changed and its role in our our view of meat/animal products [1:29:00] - How to have a societal and individual relationships with animals that are healthy for you, the community and the earth GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Kesä 20221h 47min

Part 160 - Kara Collier on Optimal Health Through Blood Sugar Regulation

Part 160 - Kara Collier on Optimal Health Through Blood Sugar Regulation

Kara Collier is a Registered Dietician Nutritionist and a co-founder of Nutri-Sense, currently leading their team of dieticians to using their continuous glucose monitoring systems to help individuals properly manage their glucose and metabolism. She graduated from Purdue University, previously worked at the Memphis VA medical center as a clinical dietician at Providence Hospital and in a management role at Nutritionix   Use code "PeakHuman" at Nutrisense for $25 off a CGM     GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES [0:30] - Kara details her past and what motivated her to get involved with healthcare, metabolic health and Nutrisense and [5:00] - How using a continuous glucose monitor can increase your awareness of how foods affect your glucose levels, energy, mood etc. [14:30] - How your body adapts to lower levels of carbohydrates in diet and its effects [16:30] - Detailing glucose and its role in metabolism [20:30] - What is a Continuous Glucose Monitor, what it tells you and who might benefit from using it [25:05] - Why Hemoglobin A1c is not the only indicator of your metabolic health and what can make those results less reliable [34:15] - Why its very hard and uncommon for the traditional healthcare system to prescribe beneficial testing as preventative care [41:10] - Lipids, LDL, HDL, Trigs and how their levels affect overall health [48:15] - Lifestyle factors and basic nutrition guidelines to maximize glucose response and metabolic health [58:00] - How Sleep and Alcohol affect glucose response and health [1:11:00] - How larger meals, like an OMAD format, affects your glucose response and metabolism [1:16:00] - Do we know if eating a bunch of fruit and sugar is good/bad?   BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

25 Touko 20221h 24min

Part 159 - Patrick Theut on the Miraculous Reversal of Heart Disease

Part 159 - Patrick Theut on the Miraculous Reversal of Heart Disease

Patrick Theut is a biochemist and engineer who has successfully managed to reverse his coronary artery disease. He has invested over 16,000 hours of study into the cause of heart disease. He has developed theories and protocols on how this disease is developed, how to stop it from progressing, and protocols to even reverse it. Vitamin K Website The ancestral health & events center in East Austin is getting closer to becoming a reality! Email Brian at hi@foodlies.org to get involved. We're looking for anyone from members to investors! GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [3:50] - Patrick details his life-changing scare with a high Coronary Artery Calcium score [14:04] - Why he thinks a MMR jab negatively affected his life [24:30] - Patrick's mission to get high quality vitamin K to solve his heart disease [29:45] - Why Patrick thinks that conventional western medicine doesn't routinely test for CAC and other root cause issues [40:00] - A breakdown of Fats, Lipids, hormonal health, and the importance of LDL [57:50] - Brian and Patrick Discuss healthy diet and lifestyle factors [1:20:00] - What to do once your get a CAC score [1:27:45] - The "hydra" of heart disease GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Touko 20221h 40min

Part 158 - Dr. Tyna Moore on The Secrets to Living a Long & Pain-Free Life

Part 158 - Dr. Tyna Moore on The Secrets to Living a Long & Pain-Free Life

11 Touko 20221h 8min

Part 157 - Jessica Thompson, PhD on How Eating Animal Fat & Marrow Made Us Human

Part 157 - Jessica Thompson, PhD on How Eating Animal Fat & Marrow Made Us Human

Specializing in human evolution and the aspects revealed through the analysis of ancient animal bones, Jessica Thomspon is a leading voice in paleo-anthropology, evolutionary theory and hunter-gatherer ethnography. She is a professor at Yale University and also leads the Malawi ancient Lifeways and Peoples Project in Malawi, in central Africa, to develop and interpret the evolutionary history in the area during the last Ice Age. Jessica thompson PhD website: https://campuspress.yale.edu/jcthompson/ The ancestral health & events center in East Austin is getting closer to becoming a reality! Email Brian at hi@foodlies.org to get involved. We're looking for anyone from members to investors! GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [0:30] - Dr. Jessica speaks about getting back on campus at Yale University and her specialties research in the field of anthropology [5:40] - Jessica's take on where and when we started as a human species [10:10] - What is the difference in diet, structure, etc. between humans and primates split around 7+ million years ago? [16:40] - Diving deep into tool marks on bones and what we can learn from them [24:40] - Jessica shares her opinion on the nuance of why our evolutionary adaptations that make us human occurred [36:10] - Did protein or fat change human evolution? [55:22] - The importance that megafauna played in our evolution and how they played into cooperation and competition in populations [57:05] - Jessica shares her thoughts on adaptations to the type of energy we consume such as milk, fat, etc. as it relates to the genes/skills that get passed down [1:01:00] - The massive shift in our modern diet in the short time frame, causing massive implications in long-term health [1:09:19] - Jessica weighs in on the role of animal products on evolution and our current health [1:17:30] - Jessica's thoughts on longevity and biological anthropology GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Huhti 20221h 37min

Part 156 - Keith Norris on Becoming Healthy & Free in Our Crazy Modern World

Part 156 - Keith Norris on Becoming Healthy & Free in Our Crazy Modern World

Keith Norris is an author, speaker, and the founder of Paleo f(x), the world's premier holistic wellness event, covering health, nutrition, spirituality, entrepreneurship and everything in between, which is happening on the 29th of April  through May 1st.    BUY ONE, GET ONE FREE TICKETS   He and his wife also recently wrote a book, Primal Uprising, The Paleo f(x) Guide to Optimizing Your Health, Expanding Your Mind, and Reclaiming Your Freedom Keith and Michelle's book Primal Uprising  Paleo f(x) tickets and teaser video   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES: [0:00] - Brian and Keith catch up and chat about when they first met and Paleo f(x) [10:02] - Keith speaks his mind on living in "bubbles" and the different types that exist in areas, the ideologies that go along with it and Brian's own bubbles [14:40] - Neuro Linguistic Programming - what it is and how to use it for more success [23:15] - Willpower, Nutrient Density, Anthropology and Vegetarianism  [47:30] - Redpilling, Food Guidelines, and Effective thinking  [1:01:00] - Censorship and confronting the establishment by beginning with yourself     GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Huhti 20221h 19min

Part 155 - Dr. Malcolm Kendrick on The True Cause of Heart Disease? The Unifying Theory

Part 155 - Dr. Malcolm Kendrick on The True Cause of Heart Disease? The Unifying Theory

Dr. Malcolm Kendrick is a General Practitioner in Medicine from Scotland, and focuses the bulk of his research and writing on cholesterol, atherosclerosis, stress, and the myths around them. He is an outspoken critic of the cholesterol focus of heart disease, overprescription of medications, and the dirty plays of statistics that some doctors use to increase their gains at the expense of their patients and general population. He is the author of three books, The Clot Thickens, Doctoring Data, and The Cholesterol Con, and runs the website drmalcolmkendrick.org GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [0:50] - Brian and Malcolm chat about Malcolm recent book, The Clot Thickens, and a brief overview of heart disease, its history and Malcolm's thoughts on it [10:01] - Malcolm details the nuance of atherosclerosis, endothelial cells, and damage to blood vessels [19:40] - Malcolm's thoughts on using LDL as a risk factor for cardiovascular events [31:20] - Myths and facts around cholesterol and its role in physiology [36:00] - Diving deep into Malcolm's thrombogenic hypothesis of heart disease, blood clots and endothelial pathology, Sickle Cell disease and Diabetes [59:21] - Nitric oxide, how it's benefits were found and how to increase it [1:04:21] - How stress correlates to increased risk of cardiovascular disease [1:08:45] - Malcolm's thoughts on lifestyle, diet, and relationships that help or hurt your chances of adverse cardiovascular events [1:14:30] - How Malcolm's thoughts on these topics have changed or cumulated over the years GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Huhti 20221h 23min

Part 154 - Zoe Harcombe PhD on the Upside Down World of Health Policy

Part 154 - Zoe Harcombe PhD on the Upside Down World of Health Policy

Zoe Harcombe, PhD is a researcher, author, blogger and public speaker in the field of diet and health. Her areas of interest/expertise are public health dietary guidelines (especially dietary fat), nutrition and obesity. She regularly is interviewed on TV, radio, newspapers and magazines.   She has a BA and MA from Cambridge University (economics/maths) as well as a Ph.D. in public health nutrition. Her thesis title was "An examination of the randomised controlled trial and epidemiological evidence for the introduction of dietary fat recommendations in 1977 and 1983: A systematic review and meta-analysis." The full document is available to site members here.   Zoe has also offered 50% a year membership to her amazing website where you get all of her articles. My listeners can use this code PH2204 https://www.zoeharcombe.com/register/membership-annual   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES [1:30] - Zoe's background and why she wrote her thesis on the lack of evidence for the introduction of food guidelines [4:30] - Cutting calories and why it doesn't work to focus on it  [10:40] - Brian asks Zoe how to properly lose fat [16:30] - Zoe's take on low carb and what she thinks we should be eating  [27:40] - Zoe's take on animal vs plant foods in relation to nutrition and protein content [39:30] - Zoe's take on the Food Pyramid and how we got into this awful situation  [50:05] - Power dynamics in society and how it relates to our approach towards kids' health in western societies [1:07:40] - Zoe's thoughts on the World Health Organization and The Great Reset [1:20:50] - How this conversation ties into the ostracisation on red meat and the organizations behind it   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

7 Huhti 20221h 30min

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