Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living13 Maalis 2019

Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Today we're talking to Stephan Guyenet who has a degree in biochemistry and a PhD in neuroscience. He's spent over 12 years in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. He wrote a great book called The Hungry Brain, speaks at conferences, is a Senior Fellow at GiveWell and scientific reviewer for the Examine.com Research Digest.

He is definitely not a low carb person which is why I had him on. He has a lot of great ideas and is a great mind in the space of nutrition. It was very interesting to hear him talk about all the great benefits he did see when he ate a low carb diet 11 years ago. Make sure to listen until the end when he talks about this.

He has some problems with certain people and aspects of the low carb community and is going on Joe Rogan's podcast soon to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic

We had some disagreement on the recommended daily allowance of nutrients - he thinks what's recommended is all you need and getting more than that is pointless. I think this is wrong. I think he's basing it on studies of worthless, non-bioavailable vitamin C pills that in excess do nothing. So in that - I agree. I don't think there's any benefit to popping a bunch of these and think we're going to cure a cold. I do know that our ancestors got estimates of 10-20 times the amount of nutrients we get today, so there's a lot more to this discussion that we didn't have time to get into.

We also disagreed on fiber which led to some carnivore talk. He got some things wrong about the member of the Grateful Dead who was a carnivore. He said he died at a young age of a heart attack. I looked into it and it turns out he was carnivore for 48 years and was in excellent health and died in a car accident at 72.

He also says we don't have longterm studies on the safety of low carb diets at the end. This isn't exactly true and furthermore, we have hundreds of thousands of years of human populations living on low carb diets to prove its safety and efficacy. He additionally mentions the low carb community makes crazy claims that aren't based on science. I'm not sure what he's referring to. Not everything can be measured anyway. If tens of thousands of people report to their doctor they aren't hungry anymore, their energy is stable, their brain is working better, they aren't addicted to sugar, they finally have control of their food intake, etc. then this is some great clinical observations and patient anecdotes that add up to a lot.

I think everyone has their own ideas about things and collects info to support their opinion. It's only natural, and I'm sure I'm doing it to, even though I'm trying not to. Everyone has to be in their camp and collect data and narratives to support their theories. He seemed to do this as you'll see throughout the episode.

I agreed with a lot of his points though, especially that humans didn't evolve to eat based on tracking macros and calories and using an excel spreadsheet to figure out what to eat. He's doing great work and looking at this from a different angle which is important. A lot of interesting stuff here so let's get to it. But first I gotta mention the Food Lies film which is in the last stretch of crowdfunding on Indiegogo. We really need your help to finish it. We have a bunch of cool perks like the Eat Meat T-shirt, the movie poster, bonus features, and more. Find it through FoodLies.org or by clicking through this link in the show notes. I really appreciate it - and now here's Stephan Guyenet.

http://indiegogo.com/projects/food-lies-post

Show Notes

  • I'm obsessed with why we get fat and what to do about it and you've been researching this for a long time
  • Why the brain is the most important place to focus on
  • The brain regulates how much we eat, our food choices, and our exercise
  • There's also non conscious processes the brain regulates that influence caloric expenditure, etc.
  • We also study the human genome to find how that plays a role in body fatness
  • When it comes to body weight, the genes that relate the most are in the brain
  • Nobody wants to overeat, but we end up doing it anyway
  • We need to look at our past to understand why we are wired to seek excess calories
  • Animals and hunter gatherers we've studied follow the Optimum Foraging Theory when they acquire food. It's all about the calories per the amount of effort
  • Because we were eating whole foods from nature, if we got enough calories, we by default we're getting all the vitamins and minerals needed
  • They didn't have white flour, sugar, or refined oils
  • We only have receptors for fat, sugar, salt, and glutamate
  • Apparently those are the nutrients that natural selection cared about most to create reward systems for
  • The Hadza people went mainly for meat, tubers, and honey and didn't go for leafy greens
  • The brain is motivated to pursue calorie containing foods, not vitamins and minerals
  • Combining bliss points make certain foods almost irresistible
  • You need to control your food environment
  • Not only don't have it sitting out so you can see certain foods, don't even have them in the house
  • How do genetics play a role? We know it's way more to do with the type of foods eaten
  • About 70% of people in countries like the US are genetically susceptible to become obese when eating the bad diet that exists there. The remaining percent just aren't as susceptible and can get away with it
  • Energy balance while always be a fact, but there's a lot more to it
  • Eat less, move more may work for some people, but it's not how we evolved. It's not a natural way to regulate body weight
  • You can set up a food environment to allow your body to naturally eat the right amount
  • You'd have to be hungry all the time to continue eating processed foods and try to lose weight
  • His definition and thoughts on nutrient density
  • Questioning the necessity of fiber
  • His views on the carnivore diet - he thinks a big factor is becoming lean and it certainly does that
  • He questions if there's long term chronic disease problems that we don't know about
  • Inuit seek some plant matter
  • Sound engineer from the Grateful Dead who was carnivore for 48 years - Stephan said he died of a heart attack at a young age. Turns out he was super healthy and died of a car accident at 72.
  • His book https://justmeat.co/docs/the-bear.pdf
  • They call him "Bear" https://dangerousminds.net/comments/uncle_johns_ham_the_grateful_deads_all-meat_diet
  • Wikipedia on him: https://en.wikipedia.org/wiki/Owsley_Stanley
  • Stephan agrees with what I always say about going to either end of the extreme with super low carb or super low fat you have great benefits
  • He's going on Joe Rogan's podcast to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic
  • What happened with Gary Taubes and Dr. Peter Attia's non profit venture NuSI - the Nutritional Science Initiative?
  • What Stephan got wrong in his blog posts
  • Why he thinks Gary Taubes is wrong and what is the evidence
  • He doesn't like the fact that Gary is calling out scientists
  • Exercise and weight loss
  • The model of obesity he subscribes to is that it's all regulated by the brain
  • Homeostatic regulation - hypothalamus controls body fatness like a thermostat
  • The hormone leptin sends feedback to your brain regarding body fat levels
  • Personal fat threshold, how someone can be skinny on the outside but fat on the inside, people can be obese but metabolically healthy, and insulin as a dam holding back fat in the cells
  • He doesn't think that eating an insulin lowering diet like low carb allows you to lose weight because of the lowered insulin
  • He thinks low carb diets and low fat diets work merely because you're taking away the extreme motivation to overeat the foods, AKA hyperplatability
  • Potato hack
  • Metabolic flexibility
  • He thinks being metabolically inflexible is more a sign of insulin resistance than anything
  • He eats about 50% carb, 18% protein, 32% fat
  • He ate a low carb diet after reading Taubes' book Good Calories, Bad Calories 11 years ago
  • He said it was about the same but one benefit was that he wasn't tied to meal times. Eating high carb he definitely knew when it was time to eat. Easier to fast
  • He was easily doing 24 hour fasts. Now on high carb it's way harder and he experiences brain fog
  • Why are low carb diets so maligned in the mainstream media and medical system?
  • What are his solutions for fixing the nation's health problems?
  • His book The Hungry Brain http://www.stephanguyenet.com/thehungrybrain/
  • His website http://www.stephanguyenet.com
  • His Twitter https://twitter.com/whsource

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Jaksot(233)

Part 185 - Layne Norton, PhD and The Great Diet Debate

Part 185 - Layne Norton, PhD and The Great Diet Debate

Layne completed a BS in Biochemistry and a PhD in Nutritional Sciences, honing his intellectual skills under Dr. Donald Layman, one of the foremost researchers on protein metabolism and fat loss in the world. He has also enjoyed success in bodybuilding, winning a natural pro card in 2006. He is the founder of BioLayne. He created the company to provide ethical, science-based coaching that synthesized real world experience with evidence based protocols. In his coaching career he has turned over 70 people pro and reshaped the way that countless people think about nutrition. https://biolayne.com GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: (9:51) There is no "one-size-fits-all" prescription in the fitness and nutrition space. (19:50) There is no such thing as "good" and "bad" foods. (24:15) Nuance is king in the fitness and nutrition space. (31:36) Don't sweat the carb/fat debate. (49:01) Layne doesn't claim to be an arbiter of truth; but, he's all for intellectual honesty. (1:03:00) Brian and Layne debate on common points of contention in nutritional science. (1:22:30) It's much easier to live an unhealthy life today compared to just three decades ago. Learn more about the individuals and studies we mentioned in today's episode: Dr. Ted Naiman: https://www.dietdoctor.com/authors/dr-ted-naiman-md "Co-consumption of Vegetables and Fruit, Whole Grains, and Fiber Reduces the Cancer Risk of Red and Processed Meat in a Large Prospective Cohort of Adults from Alberta's Tomorrow Project": https://www.mdpi.com/2072-6643/12/8/2265 Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake: https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

15 Helmi 20231h 36min

Part 184 - Dr. Scott Sherr on Optimizing Your Mitochondria For Peak Health

Part 184 - Dr. Scott Sherr on Optimizing Your Mitochondria For Peak Health

Dr. Scott Scherr is an Internal Medicine MD. CoFounder of OneBase health, COO of Troscriptions, and HOMe. A specialist in HBOT, Dr. Scott is interested in all things health/performance optimization. IG: https://www.instagram.com/drscottsherr/?hl=en Websites: https://linktr.ee/drscottsherr   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES: Coming soon       GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

8 Helmi 20231h 29min

Part 183 - Dr. Molly Maloof on True Heath in the Modern World

Part 183 - Dr. Molly Maloof on True Heath in the Modern World

Dr. Molly Maloof is a Healthspan Doctor, determined to maximize our potential with health optimization, biohacking, and personalized wellness. Founder of multiple wellness-focused organizations, and having served as medical advisor for a multitude of brands, she's on a mission to help us all live our best lives through education and health awareness. She is the author of Spark Factor: The Secret to Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever which is now open for pre-order. Dr. Molly's Website: https://drmolly.co/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES 1:55 - Dr. Molly's background 4:25 - Healthspan and the role of Mitochondria 13:30 - Blood sugar and different carb types 17:30 - The myth of the Calories in/Calories out theory 20:37 - The truth of healthcare and predictions for the industry 27:42 - Trying to stay healthy in a new environment 30:40 - How is technology changing health? 34:00 - The role of social connection in living a healthy life. 37:35 - How to make friends and improve your network 42:20 - Dr. Molly's health journey and becoming a doctor 48:58 - How trauma affects our health and navigating sexual and relationship experiences 58:20 - Women's biohacking BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Helmi 20231h 16min

Part 182- Natalie Kovarik and Tara Vander Dussen - Is Walmart Beef & Milk Healthy?

Part 182- Natalie Kovarik and Tara Vander Dussen - Is Walmart Beef & Milk Healthy?

Natalie Kovarik Natalie is a Ranch wife, mother, and social entrepreneur. She's grown from an instagram following to include her own podcast, clothing line, an online course, and she now hosts marketing retreats for women in rural lifestyles. Natalie's website: https://nataliekovarik.com Tara Vander Dussen Tara is a 5th generation dairy farmer, environmental scientist, farm wife, and mother to 2 girls. She serves as president of United Dairy Women, a charity dedicated to providing dairy to families in New Mexico. A passionate advocate for all things dairy farming. She's proudly known as the New Mexico Milkmaid when sharing online. Her mission is to share the truth about dairy farming and weed out the misconceptions about farming and farm life. Tara's Website: https://taravanderdussen.com/ Together with Tara they host the DiscoverAg podcast and help women with agriculture marketing with their Ecourses and Facebook community ElevateAg. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [4:28] - Nuances of the ranching solution. [8:00] - Types of ranching operations [11:15] - Breakdown of farm sizes and stats in the US [13:00] - Common misconception that cows spend their lives in cages [15:10] - Cattle are naturally herd animals, it gives off a misconception that they're always packed super close together when on pastures [17:53] - The majority of people have been fed the propaganda that meat is the enemy [21:00] - Are there bad players/practices in the industry? [28:40] There's a lot of arguments about how we get our food, but ultimately we still need some amount of efficiency for such large populations [34:45] How has the quality of milk/meat changed? Can cows actually eat corn and non-traditional diets. [39:52] Is marbled meat bad? [48:39] What are some of the differences in nutrition with lab grown meat? [53:10] - Is climate change a human cause? What's the truth? [59:29] Meat based diets are making a comeback and gaining traction over veganism. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

26 Tammi 20231h 13min

Part 181 - Elliot Overton on 2 Huge Nutrition Aspects That Could Change Your Health

Part 181 - Elliot Overton on 2 Huge Nutrition Aspects That Could Change Your Health

After developing some minor health issues of his own after an extended back-packing trip through Asia,  Elliot decided to take responsibility and began researching ways by which he could find resolution without the use of pharmaceutical medications. Elliot soon discovered that the solution to his problems was rooted in nutrition and basic lifestyle principles.  Elliot's  experience, and the experience of those close to him, demonstrated the power of nutritional intervention. Elliots success in improving his own health journey inspired him to study nutrition at a professional standard so that he could go on to help others along the way. Elliot trained as a nutritional therapist at the College of Naturopathic Medicine in the UK, and later gained a qualification in Functional Medicine. https://www.eonutrition.co.uk/   BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post     SHOW NOTES 01:20  How Elliot got interested in thiamine 06:50  Are you getting enough Thiamine When animals were given large doses of thiamine before being exposed to head trauma, it was shown to mitigate many of the negative ramifications of the head injury, and allow for normal functions to be carried out at a greater rate than the control group. https://www.sciencedirect.com/science/article/pii/S0005272818301208  Very high doses of B1 have been found to completely abolish symptoms of Alzheimer's disease. https://www.hormonesmatter.com/new-developments-in-high-dose-thiamine-the-legacy-of-antonio-costantini/  Large doses of thiamine have also demonstrated two almost completely abolished symptoms of fibromyalgia seemingly overnight. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669831/#:~:text=Some%20observations%20indicate%20that%20the,mitochondria%20or%20to%20enzymatic%20abnormalities.  21:20  Why don't more people know about thiamine? 38:00  Oxalates and thiamine  Elliot credits much of his knowledge of oxalates to Susan Owens, who's website can be found here: http://lowoxalate.info/  54:40  Brian's story with oxalates 59:10  signs and symptoms of oxalates issues 1:10:00 Why Elliot chose thiamine and oxalates 1:17:00  Thiamine and the diet 1:30:00  How to find Elliot  Instagram- https://instagram.com/eonutrition?igshid=YmMyMTA2M2Y= Twitter- Elliot Overton (@EO_Nutrition) / Twitter https://twitter.com/eo_nutrition?lang=en  YouTube - https://youtube.com/@EONutrition Website- https://www.eonutrition.co.uk/     BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Tammi 20231h 41min

Part 180 - Mike Mutzel Gives a Masterclass on Reading Labs & Bloodwork

Part 180 - Mike Mutzel Gives a Masterclass on Reading Labs & Bloodwork

Mike earned his B.S. in Biology from Western Washington University in 2006 and completed his M.S. in Clinical Nutrition from the University of Bridgeport in 2015 and is a graduate of the Institute for Functional Medicine's (IFM) Applying Functional Medicine in Clinical Practice (AFMCP). https://highintensityhealth.com/about/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: 00:00- Head over to https://nosetotail.org/ for our nose to tail products Go to http://drinklmnt.com/peakhuman for a free gift from LMNT electrolytes. Join the sapien newsletter https://www.sapien.org/ 04:00- It will be much better to watch the video presentation on the Food Lies YouTube 06:24- The importance of exercise 12:40- Carb cycling and timing 15:20- Effects of blood viscosity 26:38- LDL cholesterol 35:00- How to assess the liver 39:13- Benefits of cholesterol 40:56- Triglycerides and a case study 47:10- Omega 3 and 6 49:30- Vitamin D 55:30- Mike's approach to looking at labs. Case studies 1:04:20- Post menopause 1:06:23- DHEA 1:09:05- Common male bloodwork For full show notes with links to all the studies join the Patreon BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Joulu 20221h 13min

Part 179 - Dr. Aseem Malhotra on Was It Safe & Effective?

Part 179 - Dr. Aseem Malhotra on Was It Safe & Effective?

Dr Aseem Malhotra is an NHS Trained Consultant Cardiologist, and visiting Professor of Evidence Based Medicine, Bahiana School of Medicine and Public Health, Salvador, Brazil. He is a world renowned expert in the prevention, diagnosis and management of heart disease. He is honorary council member to the Metabolic Psychiatry Clinic at Stanford University school of medicine California, and is Cardiology MSc examiner at the University of Hertfordshire, UK. He is a founding member of Action on Sugar and was the lead campaigner highlighting the harm caused by excess sugar consumption in the United Kingdom, particularly its role in type 2 diabetes and obesity. https://doctoraseem.com/biography/ Get the free gift from LMNT DrinkLMNT.com/PeakHuman GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: 00:30- Introduction 04:03- How Dr. Aseem's views have changed 06:15- Transition to Rumble 08:18- A framework for the rest of the discussion 13:28- the evidence-based medicine triad 15:35- how to survive the medical miss information mess 18:30- The corruption of medicine from pharmaceutical companies 19:20- Blatant misconduct from the pharmacy industries 21:15- What about the life-saving drugs? 29:00- Statistical literacy 32:25- The effects of fear and stress 34:20- The real impact of the vaccine 49:00- Dr. Aseem's consensus on the data 1:00:00- The harms of the vaccine 1:08:00- Getting to the root of the problem? 1:28:30- Where to find the best products on the market For full show notes join the Peak Human Patreon http://patreon.com/peakhuman GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

16 Joulu 20221h 34min

Part 178 - Dr. Suneel Dhand on Big Pharma Bribing Your Doctor & Worldwide Corruption

Part 178 - Dr. Suneel Dhand on Big Pharma Bribing Your Doctor & Worldwide Corruption

Dr. Suneel Dhand is an internist in Hyannis, Massachusetts and is affiliated with multiple hospitals in the area, including Salem Hospital and Beth Israel Deaconess Medical Center. He received his medical degree from The University of Wales College of Medicine and has been in practice between 11-20 years. https://suneeldhand.com/ BUY THE MEAT NosetoTail.org FREE SAPIEN LIFESTYLE GUIDE Sapien.org SHOW NOTES: 00:18- Introduction to Dr. Dhand 05:00- Dr. Dhand transition out of the typical healthcare system 08:00- Your doctor wants you to be sick 10:00- How big pharma is bribing your doctor 11:30- Dr. Dhand approach to treating his patients 15:45- Using food as medicine 21:35- Why eating meat could actually be dangerous 23:15- Dr. Dhand's optimistic view of our health future 25:30- The corruption of medicine 30:40- The real Anthony Fauci 34:20- The intertwined agenda of big pharma, big tech, and mainstream media 41:30- Big pharma's flawed studies 50:50- Medical dictatorship and mass psychosis 58:45 - The effects of mainstream media 1:04:10- The fallacy of the "greater good" 1:18:55- Where to find Dr. Dhand BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

7 Joulu 20221h 24min

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