Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living30 Touko 2019

Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

This is an interview I've been looking forward to for years. Dr. Dale Bredesen is shaking up the medical world by showing that Alzheimer's actually can be prevented, treated, and sometimes even reversed. This is really important to me because my mom is the final stages of Alzherimer's and I, of course, am doing everything I can to prevent myself from falling to the same fate.

I believe the Sapien way of eating and lifestyle is doing just that - setting me up for my best chances at my longest healthspan. You can learn more about this at http://sapien.org/diet

Dr. Bredesen and I agree on all the core principles. He really is describing a Sapien diet with his protocol. We're only at odds with the ratio of plant foods to animal foods.

As I've posted today on social media, I think people are actually more on the side of animal foods than they think. In the context of a whole foods, low carb diet without refined grains, sugar or vegetable oil, more often than not people are getting the majority of their calories from animal foods without necessarily realizing it. Only people eating Standard American Diets or Mediterranean Diets and the like are getting most of their calories from plant foods from all the empty calories coming from grains and other carbohydrates.

Many health figures in this space say things like "a plant heavy diet" or "fill half your plate up with greens" and people take this as being akin to a vegetarian diet. As I showed in my post, a daily intake where about 70% of the plates are filled with plants are actually 92% animal foods by calories.

I actually eat this way a lot. This is carnivore adjacent and is part of the Sapien Framework. You're still getting a ton of flavor, variety, and nutrients from plants (even though they're not as bioavailable), but you're really getting 90% of your calories from animal foods. So make your own decision on the ratio of plant to animal foods, but from what I've found, higher animal foods is more species appropriate for homo sapiens, and is actually what most people avoiding empty calorie, nutrient poor foods are already doing.

As always, I didn't want to press him on this. I don't invite people on my podcast to tell them I don't agree with their opinions. I'd love for this to be debated with a moderator at some point, but as long as it's a 1 on 1 Peak Human podcast I'm letting the guest speak their minds.

Here's a bit of Dr. Bredesen's extensive resume. He received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, he was the Director of the Easton Center for Alzheimer's Disease Research, he's a Professor in the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and the Founder of the Buck Institute for Research on Aging.

The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of the disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller and has been translated into 29 languages.

I'll largely skip the plugs for today. Everyone listening knows about the Food Lies film on Indiegogo, the Patreon at http://patreon.com/peakhuman and my new grass fed meat company http://NoseToTail.org If you find any value in this podcast or my other content on YouTube or social media channels, please consider supporting me and my projects there. I wish I could really get across how much it means to me. It's honestly the only way any of this is possible. Thanks so much, and I'll most likely end season 3 with this episode and come back in a couple weeks with an amazing season 4. Here's the future legend, Dr. Dale Bredesen.

BUY THE MEAT NosetoTail.org

Preorder Food Lies: http://indiegogo.com/projects/food-lies-post

Support me on Patreon! http://patreon.com/peakhuman

SHOW NOTES

  • Dr. Bredesen has been studying the phenomenon of Alzheimer's Disease (AD) for 3 decades and have published over 200 papers on his research
  • Understanding the fundamental nature of the disease is how we can design an effective treatment
  • His protocol is different because it targets the root cause, not the symptoms like most AD drugs do
  • Humans are extremely complicated and there is no one single therapy that will treat the complexity of AD
  • AD is the result of the brain protecting itself from different insults
  • The protective response in the brain causes the brain to shrink and "retreat" so that there is less for foreign substances (insults) to target
  • Amyloids are antimicrobial, bind to toxins, and change the brain's response to glucose but when they are overproduced and build up that's when problems occur
  • Some of the contributors to AD are: chronic inflammation, insulin resistance, glycation damage, toxin exposure, decrease in nutrients, hormones, trophic factors, poor vascular support
  • He has identified and categorized 6 different types of AD: inflammatory, atrophic, glycotoxic, toxic, vascular, and traumatic
  • Paraffin candles produce toxins that damage the brain
  • Most damaging mycotoxins (produced from mold) are the ones you breathe - test your home for molds
  • Go to www.survivingmold.com to learn how to test your home for mold and if you are concerned about mold exposure to learn about what to personally get tested
  • For overall markers you should get tested, you can order tests directly from Dr. Bredesen's site www.drbredesen.com or go to your doctor and test markers
  • Markers for glycotoxicity: fasted insulin, HbA1c, and fasted glucose
  • Markers for nutrients, hormones, and trophic factors: o Vit. D, pragnenolone, progesterone, estradiol, testosterone, free T3 and free T4 (for thyroid), TSH (thyroid stimulating hormone), and reverse T3 (which is an inhibitor of the effect of your active thyroid hormone)
  • Inflammation markers: HS-CRP, TNF-a, IL6, IL8, IL1-b
  • Don't wait until it's too late to check for these things, because AD is preventable
  • Glycotoxicity and how sugar is toxic
  • Humans are not designed to eat sugar
  • Overconsumption of sugar is linked to hypertension, CVD, diabetes, dementia, arthritic, leaky gut, and more
  • Sugar is this generation's smoking, we will get to a day when we think back to how crazy it was that we were eating this stuff
  • We have biomarkers that will tell you whether AD is creeping up on you, so check early in life because you might not feel sick now, but that doesn't mean it's not on its way
  • All these lifestyle and diet changes that you make to prevent AD, apply to so many other modern illnesses
  • If AD runs in your family, you should be interested in prevention
  • AD should be a rare disease
  • APOE4 is the most common genetic risk factor
  • If you have a single copy of APOE4 the risk is ~30%
  • If you have a double copy of APOE4 the risk becomes greater than 50%
  • For people with APOE4, find out early and get on prevention, and you will have a low chance of getting the disease
  • 21st century medicine is about root cause and prevention
  • There is no mono-therapy for AD
  • Look out for symptoms of early cognitive decline like the lack of ability to learn new things, losing organizational skills, not being able to do simple calculations, not being able to find the right word, getting lost in familiar places
  • Don't shake these off as "senior moments"
  • Basic things everyone can do: optimize insulin sensitivity, follow a low-carb, moderate protein, high (good) fat diet, exercise, get enough sleep, reduce stressors in your life, detox, avoid or fix any gut issues, go into periods of ketosis
  • His diet plan is called "KetoFlex 12/3"
  • "Keto" for going into periods of ketosis
  • "Flex" because it is flexitarian, if you want to be a vegetarian or eat meat you can do either
  • "12" because he wants people fasting for at least 12 hours between dinner and the next day's first meal
  • "3" because he wants people to finish eating at least 3 hours before they go to sleep
  • The Big Four to avoid: grains, simple carbs, dairy, and lectins
  • He has had amazing success with his patients and has been publishing results since 2014
  • He has never had someone at risk come in for prevention and develop even mild cognitive impairment (MCI)
  • People who come in with subjected cognitive impairment (SCI) see improvement
  • People who come in with MCI the majority improve
  • People with full-blown AD, some people improve and some people don't
  • He has had people score zero on cognitive tests that have improved
  • The most important point of all of this is that if you get put on a drug for AD you might get a little bump but you fall back to declining again, his approach targets what is actually causing the decline, the people who get better sustain their improvement
  • Complexity gap between the complexity of the problem (human illness) and the data sets that traditional medical doctors are using to treat them (aka we can't expect a simple mono-therapy to treat a complex condition)
  • Dr. Bredesen's daughter is a brain health coach and you can find her at www.siabrainhealth.com
  • His protocol includes sauna for riding the body of toxins
  • We are swimming in an Alzheimer's soup with the amount of toxins we are exposed to in our modern world
  • Get rid of toxins by sweating (sauna and exercise), high fiber diet, optimizing glutathione levels, filtered water, urination, each one of these gets rid of different things
  • If you have leaky gut, fix that
  • The importance of sleep
  • Current research on macular degeneration
  • His new book coming out "The First Survivors of Alzheimer's Disease" will be about people's first-hand stories of people told they had no hope but used his protocol and got better and have kept themselves better
  • The future of medicine will need to look at how humans were evolutionarily designed to live
  • You are not powerless to AD, you have control over it
  • We can reduce the global burden of dementia, we can fight cognitive decline
  • Find Dr. Dale Bredesen at www.drbredesen.com
  • His Facebook page https://facebook.com/drdalebredesen/

BUY THE MEAT NosetoTail.org

Support me on Patreon! http://patreon.com/peakhuman

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

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Theme music by https://kylewardmusic.com/

Jaksot(233)

Part 209 - Ana Rosa, MD, PhD on The Hidden Fat That's Killing You

Part 209 - Ana Rosa, MD, PhD on The Hidden Fat That's Killing You

Ana Rosa, MD, PhD is a physician, Radiologist, Body fellowship trained, alumni of the University of Minnesota, medical doctor at the VA healthcare system, and assistant professor at the University of Minnesota. Dr. Rosa has done two radiology residencies, one in Brazil, and one in the United States, obtained a doctorate degree, had done a body imaging fellowship, and also has published in medical journals and helped writing Imaging books in Brazil with 25 years of practice in the Imaging field as a Radiologist. Dr. Rosa shares with us her imaging knowledge of visceral fat, the importance of its detection and description in the reports, guiding the patients and the ordering providers by the findings on cross-section imaging such as MRI scans. The podcast intention is to bring awareness on how to detect a simple and easy biomarker such as visceral fat on MRI scans making it easier for patients to advocate for health and follow up for results. Dr. Rosa shares with us how to create quality of care in service for education and interaction between patients, providers and Radiologists in sharing her own story on how to heal from inside out by literally "seeing" a "silent" metabolic active killer that visceral fat represents and taking action to change the presence status quo And move towards optimizing health. SHOW NOTES (06:37) In medical school, healthcare professionals are trained to describe diseases while overlooking how visceral fat and metabolic health contributes to them. (15:52) Visceral fat is a major culprit when it comes to various metabolic issues. (28:04) The first step to prevent disease is to look for signs of inflammation. (31:17) While it's possible to request your MRI scan from your doctor, most providers won't know how to make use of it. (44:02) Health is not limited to staying alive. Health is also appearance and performance. (53:58) For doctors, another benefit of learning to deal with patients carrying high amounts of visceral fat is potentially minimizing burnout.

22 Marras 20231h 2min

Part 208 - Mary Ruddick Debunks the Blue Zones and Explains Worldwide Health Decline

Part 208 - Mary Ruddick Debunks the Blue Zones and Explains Worldwide Health Decline

Mary Ruddick is an internationally acclaimed nutritionist currently based in Europe and Africa. She has personally trained professional nutritionists around the globe. Dubbed the "Sherlock Holmes of Health" for her unique ability to expeditiously assess and remediate rare neuromuscular conditions that others have deemed impossible, Mary Ruddick is a seasoned researcher, educator, medical nutritionist, entrepreneur, and philanthropist. Her writing has been published in medical journals and her own inspirational healing story can be found in several publications. http://enableyourhealing.com BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (10:38) The Maasai people who live the most traditional lifestyles are living what us moderns would consider a "utopia". (22:32) The mental health crisis came as a result of being unhealthy in general. (28:12) When you eat organ meat, you take in a lot of serine. (34:34) Another practice within these indigenous cultures is that there is no trading of food, meaning everything eaten is native. Their food is also traditionally processed. (45:25) You don't need to completely remove plants from your diet, but gravitate towards those that you enjoy eating and have been properly prepared to minimize toxicity. (53:12) When optimizing your nutrition, don't focus on achieving balance. Focus on avoiding deficiencies. (1:08:42) There are different levels of nutritional knowledge. (1:21:17) The concept of "Blue Zones" as presented in the mainstream is largely misrepresented. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Marras 20231h 34min

Part 207 - Veronica Max, APRN, FNP on Your Complete Health Makeover

Part 207 - Veronica Max, APRN, FNP on Your Complete Health Makeover

Veronica Max is a nurse practitioner and the CEO of UltraPersonal Healthcare. Bringing more than eleven years of family and functional medicine experience to the table, Veronica founded UltraPersonal Healthcare with the aim of creating a quality of care, service and experience that she found missing in the modern healthcare system. Just tell her Brian sent you! https://www.ultrapersonal.healthcare BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (12:24) Find a healthcare practitioner that focuses on preventing disease rather than treating disease. (16:14) Terrain theory takes into account the human body and the health of the organism. (23:31) Exposure to the sun and the elements is vital to a healthy body with normal levels of sex and thyroid hormone. (36:40) A healthy diet involves meat, fish, and seasonal fruits and vegetables. (41:44) There's ancient wisdom in the fact that all the major religions incorporate fasting. (47:21) Hashimoto's is autoimmune hypothyroidism (underactive thyroid). (55:57) Calorie restriction is a form of stress. (1:02:02) Movement is important. But if you overlook food and light, you won't meet your goals. (1:08:30) It's no coincidence that the thyroid is in the throat. (1:11:29) There's no right or wrong place for a woman to have her baby. It's important to know your options. (1:14:32) When it comes to your child's immunization schedule, it's important to educate yourself and to listen to your intuition as a parent. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

25 Loka 20231h 19min

Part 206 - Chris Kruger on How to Lose Fat the Easy Way

Part 206 - Chris Kruger on How to Lose Fat the Easy Way

Chris Kruger is a fitness coach and a promoter of the high-testosterone lifestyle. At 40 years old, he has already dedicated two full decades to assisting men worldwide in achieving their peak potential – in appearance, well-being, and overall performance – all without the need for pills, powders, prescriptions, or PEDs/TRT. http://Instagram.com/krugerbody Just DM him you want to do the SAPIEN program ck@testosteronesuperchallenge.com BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (06:19) Natural hormone optimization applies to men just as much as it applies to women. (07:20) A calorie deficit for weight loss purposes is only effective in the short-term. (16:15) Instead of restricting yourself nutritionally while trying to improve or maintain performance, go for naturally optimizing your hormones. (26:55) Don't think "energy balance". Think "energy metabolism". (37:28) True health or fitness is about living like a human should to the fullest. (53:04) Testosterone can be produced from saturated fat. (1:01:52) Your health and fitness is a reflection of the relationship you have with yourself. (1:22:46) Outside of sleep, the biggest lever you can pull is getting enough protein. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

19 Loka 20231h 32min

Part 205 - Dave Feldman on The Amazing Study of Fit People w/ High LDL Cholesterol

Part 205 - Dave Feldman on The Amazing Study of Fit People w/ High LDL Cholesterol

Dave Feldman is an independent researcher and software engineer who has gained notoriety for his work on cholesterol and lipid metabolism, particularly in the context of low-carbohydrate and ketogenic diets. Coming from a background in software engineering, Feldman took a systems engineering approach to understanding cholesterol, creating what he calls the "lipid energy model." He has presented his findings at various medical conferences and is a frequent guest on health and wellness podcasts. Although not a credentialed medical professional, Feldman's citizen science has challenged traditional views on cholesterol, encouraging more nuanced discussions around its role in health. His work has captivated a large following of both laypeople and experts interested in the complexities of lipidology. http://CholesterolCode.com BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (4:18) A study on the Lipid Energy Model (LEM) (https://pubmed.ncbi.nlm.nih.gov/35629964/) may explain why cholesterol increases in those who decide to consume fat for energy over carbs. (12:46) The status of your metabolic health influences how a particular diet affects your health, no matter the diet. (20:42) HDL at 50 or higher and triglycerides at 100 or lower are good benchmarks to strive for. (36:19) Multiple studies demonstrate that, if you take 100 random people in the same demographic with 0 risk factors, 60 male and 40 female, a little more than half of them would have 0 CAC. (44:07) Dave's ongoing companion study (follow updates at https://citizensciencefoundation.org/) running parallel to the main study features a control group with more relaxed criteria. (52:03) If we had more data on healthy populations, a clearer path towards a healthy way of life will be achieved (59:40) Visit (https://ownyourlabs.com/) which is both a blood testing service and a hub to participate in citizen science. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

4 Loka 202356min

Part 204 - Gabor Erdosi on The Root Cause of Diabetes, Disease, and Obesity

Part 204 - Gabor Erdosi on The Root Cause of Diabetes, Disease, and Obesity

Gabor is a food scientist with a master's in molecular biology. He lives in Hungary and is one of these engineers/scientists who I love talking to who look at nutrition differently. He has a very unique perspective because he worked for big food manufacturers. He spends almost all of his free time researching this stuff to help people understand how bad these processed foods actually are. He has a large community on Facebook where he shares and discusses this information. He also has some great presentations he's done you can find online. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (12:29) To determine whether a study is biased, refer first to potential conflicts of interest. (14:56) Adipose tissue is a question of function over mass. (23:53) We are adaptive organisms. (31:04) Accelerated Appearance and Absorption (AAA) takes place when your small intestinal tract is filled too quickly with ultra-processed foods (refined carbs and/or added fats). (41:03) Processed proteins are nowhere near as unhealthy as processed carbs. (55:40) Overeating doesn't necessarily equal gaining weight, and vice versa. (58:36) Adipogenesis is the generation of more fat mainly through the addition of new fat cells. (1:09:19) In general, metabolic health is a good marker of future health outcomes. (1:17:58) A diet rich in refined carbohydrates and added fats leads to the production of endotoxins that are easily absorbed. (1:27:46) Visceral fat is a protective mechanism. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Syys 20231h 28min

Part 203 - Dr. Joel Kahn Thinks You Should Go Vegan

Part 203 - Dr. Joel Kahn Thinks You Should Go Vegan

Dr. Joel Kahn is a cardiologist, integrative medicine practitioner and promoter of plant-based nutrition. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant based vegan diet that he truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics and nutrition-based recovery protocols. These ideologies led him to change his approach and focus on being a holistic cardiologist. https://www.drjoelkahn.com/ GET THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (16:52) According to Dr. Khan, if you suffer from heart disease, consider a plant-based diet based on science. (20:38) We start to develop atherosclerosis in our 20s and 30s. (31:00) We have more than enough data that a human can live through their reproductive years on a huge variety of diets. (47:08) To assess whether or not you're on the right path, assess your own cardiovascular status. (59:54) 30-40% of heart attacks, strokes, and early deaths are due to genetic factors, completely regardless of nutrition and lifestyle. (1:09:50) Examine whether or not your lifestyle is working for you. Don't just assume it is. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Syys 20231h 13min

Part 202 - Stephan Guyenet, PhD on Why Do Humans Overeat?

Part 202 - Stephan Guyenet, PhD on Why Do Humans Overeat?

Stephan J. Guyenet, Ph.D. is an obesity researcher and health writer whose work ties together neuroscience, physiology, evolutionary biology, and nutrition to offer explanations and solutions for our global weight problem. He received a B.S. in biochemistry at the University of Virginia and a Ph.D. in neurobiology at the University of Washington. He is the author of the popular health website, Whole Health Source, and is a frequent speaker on topics of obesity, metabolism, and nutrition. https://www.stephanguyenet.com/about-stephan-guyenet/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (11:16) Our brains determine our food intake and regulate our energy expenditure, in a way that works best in our ancestral environment, but not in our modern environment. (24:33) We consume calories for many reasons, hunger being just one of them. Likewise, satiety is just one of many reasons we stop eating. (34:40) As a rule of thumb, eat a diet of omnivorous whole foods that are lower in calorie density. (49:56) Fiber is not an essential nutrient. (58:35) Nutrient-to-energy is important to health, but once you have adequate intake, there's not much benefit in taking in more. (1:04:46) Most people in the US are more susceptible to obesity than others. Whether or not they actually become obese comes down to the environment they choose. (1:15:31) Blood pressure, on a genetic level, doesn't typically change as one gets older. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

12 Syys 20231h 26min

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