Digital Twins: The End of Human Drug Testing for Biohackers  : 1342

Digital Twins: The End of Human Drug Testing for Biohackers : 1342

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension.


Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life.


You’ll Learn:

• How digital twins will end human drug testing

• Why AGI could replace doctors and computer jobs within five years

• How AI models immune function, metabolism, and aging

• The role of mitochondria and inflammation in longevity

• How GLP-1 drugs and metformin extend lifespan

• What continuous biological monitoring means for health tracking

• How AI is transforming functional medicine and personalized care

• Why NAD and energy metabolism are key to human performance


They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan.


This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.


This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder


Thank you to our sponsors!


Resources:

• Keep up with Derya’s work: https://x.com/derya_?lang=en

• Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 — Trailer

01:25 — Intro

02:26 — AI’s Role in Extending Lifespan

02:56 — Regulatory Frameworks and Medical Adoption

05:19 — Problems with the Immune System

08:19 — Chronic Fatigue and Long COVID Research

10:32 — Modern Testing and Multi-Omic Analysis

14:07 — Personal Longevity Strategy and Supplements

15:17 — Understanding Exhausted Cells

23:43 — Personalization in Medicine and AI Analysis

31:35 — Longevity Escape Velocity

36:13 — AI Doctors and Prescriptions

39:55 — Data Quality Concerns in AI Training

43:19 — The Future of Wearable Technology

45:50 — Revolutionizing Education with AI

49:04 — The Future of Higher Education

52:03 — Future of Work and AI Agents

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

This episode brings to light an ex-vegan advocate’s journey to eating a mostly meat-embraced Bulletproof diet. Kristen ‘Raw’ Suzanne, author, popular blogger, and nutrition researcher, shared her former vegan assumptions, how easy or difficult it was to change, and the ethics of food. We also dove into a detailed conversations about liver meat, fertility issues on a vegan diet, how to stay Bulletproof when traveling with family, and how to nourish your kids the best way possible. In 2005, Kristen walked away from her corporate career in executive-level operations to focus on her true passion: healthy food. Already a vegan for two years, she turned her attention to the raw vegan cuisine and lifestyle, initially teaching classes and providing personal chef services, but as her online audience grew, she ultimately shifted to full-time blogging, recipe development, and eventually publishing 12 books on raw vegan diets. By 2012, concerns with her and her child's health forced her to reevaluate the nutritional claims made by advocates of raw and vegan diets. After Kristen introduced high quality animal products into her family's diet, she saw dramatic improvements almost immediately. Her family now eats a diet high in grass-fed beef and butter, bison, pastured eggs, and wild-caught seafood, while avoiding grains, gluten, and soy. While her personal transformation and conversion from vegan to omnivore has been controversial in the vegan and raw food community, Kristen has been on hiatus from blogging to spend time researching and fully exploring the nutritional and culinary aspects of eating in this new way for her family. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Elo 201357min

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

Welcome to our first ever VIDEO and audio podcast, where we’re celebrating by exploring everyone’s favorite topic – sex! This episode, with co-author of New York Times best seller, Sex at Dawn: How We Mate, Why We Stray, and What it Means for Modern Relationships, Christopher Ryan, gives you a peak into the evolutionary view of human sexual behavior. Sex at Dawn shatters myths surrounding the societal history behind how men and women interact in sexual relationships. Christopher made for a great interview, as he continues to rustle feathers around the ideas of traditional relationships.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Heinä 201353min

#51 Transhumanism, Technology & the Future with Natasha Vita-More

#51 Transhumanism, Technology & the Future with Natasha Vita-More

This episode stretches the boundaries of biohacking by looking at the futurist ideology and movement called transhumanism. Natasha Vita-More, an American designer, theorist and author, joined me on this episode to discuss the possible transformation of the human condition by developing technologies that enhance intellectual, physical, and psychological capacities.  Natasha Vita-more is co-editor and author of The Transhumanist Reader: Classical and Contemporary Essays on the Science, Technology and Philosophy of the Human Future and designer and author of "Primo Posthuman," a pioneering future whole body prototype. Vita-More is a professor at the University of Advancing Technology, and a Fellow of the Institute for Ethics and Emerging Technologies and the Hybrid Reality Institute. She is currently Chairman of the Board of Directors of Humanity+. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Heinä 201349min

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

The 50th episode of Bulletproof Executive Radio introduces you to a brand new free iPhone app called Bulletproof(R) Food Sense and to the scientist who made it all happen.  Today’s interview is with long time biohacker and founder of Sweetwater Health™, Ronda Collier. Ronda is putting her more than 25 years of experience in high tech to work at SweetWater Health™, where they are looking at the signal coming from the human heart, and instead of seeing beats per minute or simple heart rate variability, seeing a huge pool of big data just waiting to be analyzed using Ronda’s crazy advanced math skills. There is a lot more information in your heartbeat than you’d think – stress levels are just the beginning. By applying mobile health monitoring and stress management with medical research techniques, SweetWater Health is creating some very advanced, very easy to use biohacking technologies. My experience as a bio hacker who used to weigh 300 pounds and really struggled with food cravings, is that every single person has a set of things in their environment or their food that makes them weak. SweetWater Health and Bulletproof Executive just partnered to create the free Bulletproof(R) Food Sense iPhone app to help you find your personal kryptonite by using the phone’s onboard sensors to detect your hidden food sensitivities.   You can also get an amazingly full-featured version of the app that works with a chest strap to measure and track your heart rate variability all day long and use complex algorithms to quantify your food, stress, and overall health. Click here to download your free Bulletproof Food Sense app from the Apple iTunes store. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Heinä 201348min

#49 Q & A Eggs, Butter & Zen - Podcast

#49 Q & A Eggs, Butter & Zen - Podcast

About once a month, I set aside a whole podcast to answer questions from the Bulletproof community. It's all about answering your very best questions, sourced from e-mail, Facebook, Twitter, the Bulletproof forum and the blog! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Heinä 201359min

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

This podcast is with Abel James – a #1 best-selling author, fat loss coach, musician, radio show host, and veritable health crusader. Abel also runs the extremely popular “Fat Burning Man” show – which is one of the top health podcasts on iTunes.  A former strategic advisor to the food and beverage industry, Abel now acts as a consumer advocate who exposes the truth behind deceptive marketing practices, misleading corporate propaganda, and powerful special interests that have accelerated the worldwide obesity epidemic and health crisis. Abel harnesses the techniques he developed for the Lean Body System to achieve extremely compelling results in fat loss and health for his clients and the community. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Heinä 201356min

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

Jordan Rubin is one of America’s most recognized and respected natural health experts. He is the author of the New York Times best selling book, The Maker’s Diet, as well as the author of 19 other health related titles, including his latest work Perfect Weight America. An international motivational speaker, Jordan hosts the weekly television show Extraordinary Health that reaches more than 30 million households worldwide. He is Founder and CEO of Garden of Life, a leading health and wellness company committed to empowering extraordinary health with whole food based supplements, functional foods, and founder of Beyond Organic. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Kesä 201349min

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

Reichart Von Wolfsheild, is a co-host on History Channel’s Invention USA.  He is a technologist, inventor, artist and futurist. Starting in his teens, he designed and built a computer CPU from scratch. In the early 1980s, while helping pioneer music videos for the then-fledgling network, MTV, he started his first successful technology company developing Artificial Intelligence applications. Blending his talents from several fields he made history conceiving one of the first multi-player modem video games, kicking off a franchise. He has designed everything from toys to weapons and developed more than 120 products for companies such as Boeing, Disney, Dreamworks and Mattel, and is always looking for the next fun challenge. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Kesä 201346min

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